FORMULASI DAN UJI AKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN LIDAH BUAYA (Aloe vera) DAN DAUN KEMANGI (Ocinum sanctum L.) SEBAGAI ANTI JERAWAT TERHADAP BAKTERI Staphylococcus epidermidis

Yasir, Angga Saputra; Marcellia, Selvi; Wijaya, Lintang Buwana; Putri, Tika Rahayu

doi:10.36423/pharmacoscript.v4i1.610

Cited by 3 publications

(3 citation statements)

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“…Yield becomes a measure of solvent capacity in extracting chemical content. The yield of EDLB in this study was lower than that resulted by a previous study (22.32% yield), although both used simplicia powder as an extraction material and 96% ethanol solvent (Yasir et al, 2021). Meanwhile, other study obtained a low yield (1.20%) when using fresh aloe vera and extracted with 96% ethanol , but other researchers obtained a yield of 12.28% because the extraction technique was different even though using fresh aloe vera (Martono & Suharyani, 2018).…”

Section: Simplicia Extractcontrasting

confidence: 75%

SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923

Sulistyani

Almahdi

Zainab

et al. 2022

JFSP

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Aloe vera leaf (Aloe vera L.) and cherry leaf (Muntingia calabura L.) contain bioactive compounds that serve as the potential antibacterial agent. The combination treatment of multiple extracts can produce a stronger effect than a single compound. This study aims to determine the synergistic combination of aloe vera leaf extract (EDLB) and cherry leaf extract (EDK) as an antibacterial agent against Staphylococcus aureus ATCC 25923. The extract was obtained by maceration using 96% ethanol. Chemical content in the extract was analyzed by tube test and thin layer chromatography (TLC). Antibacterial activity against S. aureus ATCC 25923 was measured by the checkerboard microdilution method on a 96 well microplate. The effect of the combination of extracts on antibacterial activity was based on the fractional inhibitory concentration index (FICI) value. EDLB and EDK contain flavonoids, tannins, alkaloids, and saponins. The second combination showed a synergistic effect with a FICI value of 0.5 in inhibiting the growth of S. aureus with minimal inhibitory levels in a mixture of 0.625 mg/mL EDLB and 2.5 mg/mL EDK.

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Section: Simplicia Extractcontrasting

confidence: 75%

SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923

Sulistyani

Almahdi

Zainab

et al. 2022

JFSP

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“…Another study by Royani et al (2022), that as an antibacterial plant, A.vera contains active substances such as saponins, tannins, and flavonoids. Phytochemical screening of Aloe vera extract using 96% ethanol solvent also showed that the sample contained active compounds, namely phenolic compounds, flavonoids, tannins, and saponins, and was negative for alkaloid compounds (Yasir et al, 2021).…”

Section: Content Of Active Compounds In Aloe Vera Extractmentioning

confidence: 99%

Activity Test of Antibacterial Compounds of Aloe Vera Extract Against Edwardsiella Tarda Bacterial Infection in Vitro (technique)

Anarkhis

Prajitno

Maftuch

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Edwardsiella tarda is a type of gram-negative intracellular pathogen that can cause mass demise in fish farming. The development of edwarsiellosis due to E.tarda infection causes significant economic losses for cultivators. Aloe vera is a perennial succulent plant like a cactus, drought withstand, and belongs to the Liliaceae family, of which there are more than 360 known species (Wijaya and Masfufatun, 2022). Aloe vera is one of the plants known to contain active ingredients that can inhibit the growth of bacteria. The results of phytochemical analysis of a crude extract of Aloe vera showed the presence of active compounds, specifically flavonoids, tannins, triterpenoids, and saponins. MIC analysis showed that the lowest absorbance value of Aloe vera was obtained at a concentration of 50 mg/L with a value of 0.316, indicating a decrease at each concentration. The concentration of 50 mg/L is close to the positive control which indicates that at a concentration of 50 mg/L, it can be the reference for the lowest concentration in determining the dose of Aloe vera extract which is known that the presence of antibacterial compounds in Aloe vera extract can inhibit the growth of E.tarda bacteria. The inhibition zone test was carried out with graded concentrations of 50 mg/L, 100 mg/L, 150 mg/L, 200 mg/L and 250 mg/L with an observation time of 24 hours post-incubation and 48 hours post-incubation. Inhibition zone analysis with the highest diameter was at 200 mg/L. SEM analysis by distributing a crude extract of Aloe vera affected E.tarda bacteria specifically, lysis occurring in bacterial cells

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“…Menurut Zakaria (2022), Kombinasi ekstrak daun kemangi dan daun jeruk nipis mampu menurunkan laju pertumbuhan terhadap bakteri S. aureus. Kombinasi ekstrak lidah buaya dan daun kemangi memberikan efek kenaikan clear zone yang tercipta terhadap S. epidermidis dari 15 mm menjadi 16 mm (Yasir, 2021) Kedua tanaman terindikasi mengandung senyawa metabolit sekunder yang mempunyai daya antibakteri yang dibuktikan dalam penelitian-penelitian terdahulu sehingga menjadi dasar diperlukannya uji lanjutan mengenai kombinasi kedua ekstrak dalam menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk menguji aktivitas ekstrak kombinasi kulit alpukat dan daun kemangi serta ekstrak tunggal masing-masing.…”

Section: Pendahuluanunclassified

Aktivitas Antibakteri Kombinasi Ekstrak Kulit Alpukat dan Daun Kemangi Terhadap Pertumbuhan Staphylococcus epidermidis

Susanti,

Asri

2024

LenteraBio

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Staphylococcus epidermidis merupakan bakteri umum dijumpai di kulit manusia yang bisa berubah menjadi patogen saat imun lemah. Pemberian antibiotik dapat meningkatkan resistensi bakteri dan mengakibatkan toksisitas bagi tubuh, sehingga perlu dilakukan eksplorasi bahan alam yaitu kulit alpukat dan daun kemangi. Kedua bahan alam mempunyai senyawa bioaktif sebagai antibakteri. Tujuan penelitian yaitu untuk menguji aktivitas antibakteri dari kombinasi ekstrak kulit alpukat dan daun kemangi, maupun ekstrak tunggal masing-masing. Penelitian dilakukan menggunakan metode sumuran dengan berbagai kombinasi ekstrak kulit alpukat: ekstrak daun kemangi (1:3, 2:2, 3:1), ekstrak tunggal kulit alpukat, ekstrak tunggal kemangi, kontrol positif (kloramfenikol), dan kontrol negatif (aquades). Hasil uji one way ANOVA diteruskan uji Duncan menyatakan setiap perlakuan bisa membatasi pertumbuhan S. epidermidis. Hasil penelitian menyatakan bahwa terdapat aktivitas antibakteri terhadap S. epidermidis atas kombinasi ekstrak kulit alpukat: ekstrak daun kemangi (1:3, 2:2, 3:1), ekstrak kulit alpukat, ekstrak daun kemangi, kontrol negatif dan kontrol positif rata-rata secara berturut yaitu 15,98 mm, 17,97 mm, 16,65 mm, 19,75 mm, 9,22 mm, 0mm, dan 23,18 mm. Ekstrak terbaik dalam membatasi pertumbuhan S. epidermidis adalah ekstrak tunggal kulit alpukat. Hasil penelitian dapat digunakan sebagai rujukan untuk perkembangan obat dalam industri farmasi.

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FORMULASI DAN UJI AKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN LIDAH BUAYA (Aloe vera) DAN DAUN KEMANGI (Ocinum sanctum L.) SEBAGAI ANTI JERAWAT TERHADAP BAKTERI Staphylococcus epidermidis

Cited by 3 publications

References 0 publications

SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923

SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923

Activity Test of Antibacterial Compounds of Aloe Vera Extract Against Edwardsiella Tarda Bacterial Infection in Vitro (technique)

Aktivitas Antibakteri Kombinasi Ekstrak Kulit Alpukat dan Daun Kemangi Terhadap Pertumbuhan Staphylococcus epidermidis

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