FORMULASI DAN EVALUASI SALEP EKSTRAK DAUN GULMA SIAM (Chromolaena odorata  L.) DENGAN VARIASI BASIS SALEP

Hasrawati, A.; Famir, Yasir; Aztriana, Aztriana; Mursyid, A. Mumtihanah

doi:10.33096/jifa.v11i1.514

Cited by 2 publications

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“…Kemantapan memainkan peran dan kapasitas penting dalam membantu kemajuan pengobatan dengan penanganan, baik obat baru maupun detail baru. Kekosongan obat dapat dicirikan sebagai kekuatan atau kapasitas suatu barang untuk tetap pada norma yang telah ditentukan sebelumnya, misalnya sesuai dengan sifat fisik, zat bermanfaat, dan toksikologi yang ditetapkan untuk menjamin karakter, kekuatan, kualitas, dan keutamaan definisi [6]. Bahan pengikat esensial yang digunakan dalam pengobatan konsentrat ikan gabus dan madu kelulut adalah Adeps lanae.…”

Section: Pendahuluanunclassified

Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama)

Dwi Anugerah,

Taurina,

Andrie

2022

JSSCR

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Based on the results of research, snakehead fish extract and kelulut honey have properties to make wounds heal faster. Ointment with an active formulation of snakehead fish extract and extract of kelulut honey showed an oxidation process that could make the preparation rancid. The addition of BHA and Vitamin C is expected to prevent the oxidation process so that the preparation does not become rancid. This study aims to determine the effect of adding Antioxidant BHA and Vitamin C in preventing the oxidation process of the ointment in the aqueous phase of extracts of snakehead fish (Channa Striata)and of kelulut honey (Heterotrigona Itama) at 28 days storage. Stability was accelerated at a temperature of 40 ± 20ºC and a RH of 75 ± 5%. Variations in the concentration ofiBHA and Vitamin C used were BHA.0.02. : Vitamin C 0.1, BHA 0.02 : Vitamin C 0.01, BHA 0.005 : Vitamin C 0.01, and BHA 0.005 : Vitamin C 0.1 then tested the physical properties of the ointment, namely through organoleptic test, homogeneity test, spreadability test, adhesion test, protection test and acid number test which were then analyzed by SPSS. Based on the analysis of the scattering power showed a significant difference between F0, F1, and F3. The results of the adhesion analysis showed that there were significant differences in each formula. Furthermore, the results of the stability test showed that all formulas had good physical stability. Conclusion: F1 is a very good formula to prevent oxidation in the preparation as evidenced by a decreased acid number, which is 9.62 mg KOH/g.

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Section: Pendahuluanunclassified

Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama)

Dwi Anugerah,

Taurina,

Andrie

2022

JSSCR

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Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (heterotrigona itama) Ointment Combination with Tween 80 and Span 80 as an Emulsifying Agent

2021

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The combination of Snakehead Fish and Kelulut Honey has activity in accelerating the wound healing process. The ointment with active ingredients of Snakehead Fish extract and Kelulut Honey showed separation from the active ingredient and its base. The addition of tween 80 and span 80 is expected to increase the stability of the ointment preparation by keeping the water-phase droplets distributed uniformly on the ointment base. This study aimed to determine the effect of adding Tween 80 and Span 80 on the stability of the ointment preparation. The ointment was made by varying Tween 80 and span 80 by 2,5%: 5%: 7,5% and control (active ingredients without the addition of tween 80 and Span 80) as a comparison. The preparation was subjected to an accelerated stability test using a temperature of 40 ° ± 2 ° C / Relative humidity 75% ± 5% for 28 days by observing the organoleptic test, adhesion, spreadability, homogeneity test, pH test, and protection power. The data obtained were analyzed statistically using One Way Anova. The analysis showed that the addition of tween 80 and span 80 with a total concentration of 5% and 7,5% had a significant effect in increasing the spreadability, decreasing adhesion, and reducing the pH of the preparation. Formulas that meet the requirements in this study are F2 and F3, which have an average spreadability of 5,11 cm and 5,25 cm, adhesion of 96 seconds and 51 seconds, and pH of 6,02 and 5,02.

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FORMULASI DAN EVALUASI SALEP EKSTRAK DAUN GULMA SIAM (Chromolaena odorata L.) DENGAN VARIASI BASIS SALEP

Cited by 2 publications

References 0 publications

Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama)

Uji Aktivitas Antioksidan Sediaan Salep Ikan Gabus (Channa Striata) Kombinasi Vitamin C dan Madu Kelulut (Heterotrigona Itama)

Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (heterotrigona itama) Ointment Combination with Tween 80 and Span 80 as an Emulsifying Agent

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