Formualtion and Development of Mucoadhesive Sustained Release Buccal Tablets and Patches of 5-Fluorouracil Using Different Polymers

Abstract

Objective: The present research study was undertaken to formulate mucoadhesive sustained release buccal tablets and patches of 5-fluorouracil (5-FU).Method: For the research experiment work design expert software version 10, stat-ease, Inc. has been used. A 3 2 full factorial design was selected for the formulation of the buccal tablet as well as buccal patches. In this research work, formulated tablets and patches using different polymers such as carbopol 974p, polyvinylpyrrolidone-K 30, sodium deoxycholate, microcrystalline cellulose, and polyvinyl alcohol. An after formulation of batches formulated products studied for characterization, namely, Fourier transform infrared (FTIR) and differential scanning calorimeter (DSC). Evaluation parameters studied such as weight uniformity, thickness, hardness, friability, and content uniformity also carried out. For drug release purpose from the formulation of buccal tablet and patches in vitro drug released performed. In vivo drug releases study also carried out using Rabbit for drug reaction point of view.Results: Design expert showed the significant results on independent and dependent variables. The R-Squared 0.9943 for drug release and 0.9985 for swelling index is in reasonable agreement with the formulations. FTIR and DSC indicating compatibility of the drug and polymers in the tablet formulation and patch formulations at the molecular level. The drug release of buccal tablet showed 75.10-99.34% and buccal patches showed 58.41-81.43%. These formulations showed good results when compared to the conventional tablet. Conclusion:Formulation of mucoadhesive sustained release buccal tablets and patches of 5-FU successfully done using different polymers, which would definitely help in increasing bioavailability of the drug.

Solid Dispersion of Nebivolol Hydrochloride Impregnated Buccal Patch: Formulation and Characterization

“…The optimum moisture content in the formulations helps the film to remain stable, non-brittle and free from completely drying. Optimum values of moisture absorption in F3 formulation indicate less chance of microbial contamination and maintain integrity through the films shelf life [19,20].…”

“…The slow drug release mechanism for higher polymer concentration can be explained by the reduction in permeability due to change in the morphology of the polymer. Improved polymer concentration may have providing the matrix with greater tortuosity and deprived water porosity for diffusion of drug [20,21]. In vitro release of drug also depends on nature of plasticizer.…”

Formulation and Evaluation of Fast Dissolving Film of Lornoxicam

“…The folding endurance was determined by repeatedly folding one film at the same place until it brokes. The number of times the film folded at the same place without breaking or cracking gives the value of folding endurance and folded up to 300 times that is satisfactory to reveal good film properties [12].…”