Formation of silk fibroin nanoparticles in water-miscible organic solvent and their characterization

Silk fibroin nanoparticles constitute a vector for controlled release of resveratrol in an experimental model of inflammatory bowel disease in rats

“…7 In addition, fibroin can be elaborated as micro-and nanoparticles, with excellent properties as vectors for drug delivery. [8][9][10] Many compounds can be encapsulated in fibroin particles, such as proteins, like insulin; 11 antitumorals, like paclitaxel; 12 and curcumin. 13 In addition, fibroin is highly biocompatible, and its degradation products from the action of proteases are peptides that are easily reabsorbed by the tissues.…”

Structural and Characteristics Change of Water Hyacinth Fiber due to Combine Effect of Plasma and Nano-technology

“…The crystallinity index (C.I) of water hyacinth fiber by height has been done [31] using a computing stratergy as follows,…”

Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release

“…Silk fibroin was isolated from Bombyx mori cocoons following a degumming protocol with modifications (Zhang et al, 2007). Briefly, the cocoon shells of silkworm Bombyx mori were degummed twice in a boiling solution of 0.5% Na 2 CO 3 for 0.5 h, at 90 • C, and the resulting degummed fibers were subsequently dissolved, in a ternary system, i.e.…”

“…Silk fibroin has been investigated as a carrier for BMPs in several contributions by Kaplan and colleagues, in form of membranes for healing cranial defects in mice (Karageorgiou et al, 2004), electrospun nanofibers (Li et al, 2006), and scaffolds used for critical size defects in rats (Kirker-Head et al, 2007) and mice (Karageorgiou et al, 2006). Fibroin has been recently described to produce microparticles when precipitated with ethanol at specific fibroin concentrations and freeze temperature (Nam and Park, 2001;Cao et al, 2007;Zhang et al, 2007). Ethanol causes a shift in the random coil structure of fibroin to an insoluble beta-sheet configuration (Nam and Park, 2001).…”

“…Ethanol causes a shift in the random coil structure of fibroin to an insoluble beta-sheet configuration (Nam and Park, 2001). The addition of ethanol to the fibroin solution causes it to either precipitate to form a gel that can be used as a scaffold for tissue engineering (Nazarov et al, 2004;Tamada, 2005) or to form a gel consisting of micrometric particles (Nam and Park, 2001;Zhang et al, 2007). If these variables are controlled, a control of particle size is possible and could be adapted to specific clinical applications.…”