Formation of silk fibroin matrices with different texture and its cellular response to normal human keratinocytes

Min, Byung‐Moo; Jeong, Lim; Nam, Young Sik; Kim, Jin Man; Kim, Jin Young; Park, Won Ho

doi:10.1016/j.ijbiomac.2004.08.004

Cited by 184 publications

(84 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent years, interest in silk fibroin (SF) has been rapidly increasing because of the advent of new applications, particularly in biomedical fields, such as scaffolds for tissue engineering [6], drug delivery systems [7], artificial skin, [8], cartilage tissue [9], biosensors [10], artificial bone regeneration [11], and wire ropes for the substitution of the anterior cruciate ligaments [12] etc. This interest arises from the unique mechanical properties of SF [13,14] and its excellent biocompatibility, environmental stability, biodegradability and the capacity to support cell and tissue growth [15,16].…”

Section: Introductionmentioning

confidence: 99%

Surface Morphology and Properties of Bombyx mori Silk Fibroin Fiber Treated with I 2-KI Aqueous Solution

Khan

Gotoh

Morikawa

et al. 2009

Textile Research Journal

View full text Add to dashboard Cite

.jp ABSTRACTThe surface morphology, thermal and mechanical properties of Bombyx mori silk fibroin (SF) fiber treated with a 1.23 N iodine-potassium iodide (I 2 -KI) aqueous solution were investigated using scanning electron microscopy (SEM), atomic force microscopy (AFM), differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, and tensile measurements to clarify the effects of the iodine treatment. SEM and AFM analyses indicated that the SF fiber surface became rougher by the absorption of polyiodide ions. The mechanical properties of iodinated SF showed an increase in Young's modulus, and strain remained constant although ultimate tensile strength slightly decreased. The thermal stability of SF molecules was greatly enhanced by iodine treatment. Iodinated SF fibers should be an attractive candidate for biomedical applications such as for producing antimicrobial filters, iodine containing wound-healing anion exchange fibers, etc.

show abstract

Section: Introductionmentioning

confidence: 99%

Surface Morphology and Properties of Bombyx mori Silk Fibroin Fiber Treated with I 2-KI Aqueous Solution

Khan

Gotoh

Morikawa

et al. 2009

Textile Research Journal

View full text Add to dashboard Cite

show abstract

“…With a long history of textile use, beginning with the ancient Chinese, silk has recently been applied for the fabrication of tissue engineering scaffolds [105][106][107][108][109][110][111]. One of the most significant properties of silk is its excellent mechanical properties.…”

Section: Natural Polymeric Nanofibrous Scaffoldsmentioning

confidence: 99%

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Li¹,

Shanti²,

Tuan³

2003

Nanotechnologies for the Life Sciences

View full text Add to dashboard Cite

The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

show abstract

“…[17][18][19] Synthesized proteins can be processed using traditional manufacturing techniques, such as wet spinning or electrospinning, to produce protein based fibers for medical applications, such as vascular grafts or tissue engineered scaffolds. [20][21][22] In this review, we will examine the design rules mediating protein self-assembly on the molecular level, and the current technologies available to build protein-based textiles, and the tools available to test these properties across multiple spatial scales.…”

Section: Introductionmentioning

confidence: 99%

Protein-Based Textiles: Bio-Inspired and Bio-Derived Materials for Medical and Non-Medical Applications

Deravi¹,

Golecki²,

Parker³

2013

Journal of Chemical and Biological Interfaces

View full text Add to dashboard Cite

The hierarchical structure-dependent function of self-assembling proteins regulates the biochemical and mechanical functions of cells, tissues, and organs. These multi-scale properties make proteins desirable candidates for novel supramolecular materials that require tailored properties and customizable functions. The ability to translate molecular domains of proteins into the bulk production of conformable materials, such as textiles, is restricted by the current limitations in fabrication technologies and the finite abundance of protein starting material. We will review the common features of self-assembling proteins, including their structure-dependent mechanical properties and how these characteristics have inspired techniques for manufacturing protein-based textiles. These technologies coupled with recent advances in recombinant protein synthesis enable the bulk production of fibers and fabrics that emulate the hierarchical function of natural protein networks.

show abstract

Formation of silk fibroin matrices with different texture and its cellular response to normal human keratinocytes

Cited by 184 publications

References 38 publications

Surface Morphology and Properties of Bombyx mori Silk Fibroin Fiber Treated with I 2-KI Aqueous Solution

Surface Morphology and Properties of Bombyx mori Silk Fibroin Fiber Treated with I 2-KI Aqueous Solution

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Protein-Based Textiles: Bio-Inspired and Bio-Derived Materials for Medical and Non-Medical Applications

Contact Info

Product

Resources

About