Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction

Sonvico, Fabio; Cagnani, A.; Rossi, Alessandra; Motta, S.; Bari, Maria Teresa Di; Cavatorta, F.; Alonso, Marı́a José; Deriu, A.; Colombo, Paolo

doi:10.1016/j.ijpharm.2006.06.036

Cited by 183 publications

(148 citation statements)

References 15 publications

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“…This result is consistent with studies that previously reported ionic interrelations of self-organized nanoparticles of lecithin and chitosan (Sonvico et al, 2006) and polyarginine and hyaluronic acid (Oyarzun-Ampuero et al, 2011).…”

Section: Nuclear Magnetic Resonance Spectroscopysupporting

confidence: 93%

“…However, HA-Lys complex at 35,000 X magnification ( Figure 2c) were almost spherical in shape and showed nanometric size and smooth surface. These data are consistent with the mean size obtained by Zetasizer Nano ZS90 in the literature (Sonvico et al, 2006;Oyarzun-Ampuero et al, 2011). groups was recorded at 3443 cm -1 in FTIR spectrum of HA (Figure 3a).…”

Section: Morphological Analysissupporting

confidence: 92%

“…This nanoscale material is the result of a spontaneous formation possibly by ionic interaction between carboxylic acid of HA and primary amine of Lys, as demonstrated in Figure 1. Previous studies have already reported this kind of selfassembled nanoparticles using another polysaccharide, chitosan, for various purposes in the pharmaceutical field (Sonvico et al, 2006).…”

Section: Preparation Of Ha-lys Nanoparticlesmentioning

confidence: 93%

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Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling

Carneiro

Döll-Boscardin

Fiorin

et al. 2016

Braz. J. Pharm. Sci.

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Skin aging causes changes such as wrinkles and flaccidity leading to a large demand for aesthetic procedures, including dermal filling. A key agent in dermal filling is hyaluronic acid (HA), which is a naturally occurring glycosaminoglycan. However, it is a hydrophilic macromolecule that experiences great difficulty in crossing the skin barrier causing most commercial formulations containing it to be injectable, which in turn brings risks since they involve an invasive technique. In that sense, the aim of this study was to develop and characterize nanoparticles obtained from ionic interaction between HA and lysine (Lys) for use as a potential agent of dermal filling for topical application, increasing and improving its applicability and safety. To this end, nanoparticles were obtained by dripping of Lys over HA under magnetic stirring. A nanometric size was confirmed and a suitable surface charge was obtained by zeta potential. Nanoparticles were almost spherical in shape with a smooth surface. Interaction between raw materials for preparing nanoparticles was studied by FTIR and NMR spectroscopy and an ionic interaction was confirmed. These physicochemical features suggest that obtained nanoparticles can be further used as a topical dermal filling.Uniterms: Nanotechnology. Skin aging/non-invasive method. Skin aging/treatment/study.

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Section: Nuclear Magnetic Resonance Spectroscopysupporting

confidence: 93%

Section: Morphological Analysissupporting

confidence: 92%

Section: Preparation Of Ha-lys Nanoparticlesmentioning

confidence: 93%

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Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling

Carneiro

Döll-Boscardin

Fiorin

et al. 2016

Braz. J. Pharm. Sci.

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“…The ability of these particles to encapsulate both hydrophobic and hydrophilic material was assessed with progesterone and metoclopramide hydrochloride, respectively. The encapsulation of the hydrophilic metoclopramide hydrochloride was nearly impossible, while that of the lipophilic progesterone was possible with encapsulation efficiency up to about 64% [90]. This particle system provides an interesting particle platform with facile preparation, high encapsulation efficiency of hydrophobic drugs, and pH and ionic strength-dependent aggregation behavior.…”

Section: Polysaccharide-phospholipid Nanoparticlesmentioning

confidence: 99%

“…Ionic polysaccharide complex particles were prepared from soy lecithin and chitosan in aqueous solution by Sonvico et al [90]. Lecithin is a mixture of phospholipids, which contain negatively charged phosphate moieties.…”

Section: Polysaccharide-phospholipid Nanoparticlesmentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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Chitosan‐Based Systems for Ocular Delivery of Biopharmaceuticals

Vyas

Paliwal

2012

Chitosan‐Based Systems for Biopharmaceuticals

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Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction

Cited by 183 publications

References 15 publications

Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling

Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling

Self-assembled polysaccharide nanostructures for controlled-release applications

Chitosan‐Based Systems for Ocular Delivery of Biopharmaceuticals

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