Formation of Ordered Structure in Liquid Phase and Its Use for Materials Design. Control of Polymer Coating Thickness of Microcapsules Containing Inorganic Microparticles Using Cosolvency of Supercritical Carbon Dioxide.

Mishima, Kenji; Matsuyama, Kiyoshi; Furukawa, Akinori; Fujii, Takashi; Shida, Jun; Nojiri, Naoki; Kubo, Hideaki; Katada, Naoki

doi:10.1252/kakoronbunshu.27.700

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…129 To improve the solubility of coating polymers in the DG phase, Mishima et al modified the DG by adding cosolvents. 130 Different polymers were dissolved in dense CO 2 mixed with low-molecular-weight alcohol. Microparticles were suspended in the DG solution, and the system was depressurized through an expanding device.…”

Section: Particle Coatingmentioning

confidence: 99%

“…Microparticles were suspended in the DG solution, and the system was depressurized through an expanding device. 130 The technique has been applied to the coating of microparticles of proteins, such as lipase and lysozyme. The coating thickness was dependent on the polymer concentration.…”

Section: Particle Coatingmentioning

confidence: 99%

“…To improve the solubility of coating polymers in the DG phase, Mishima et al modified the DG by adding cosolvents . Different polymers were dissolved in dense CO 2 mixed with low-molecular-weight alcohol.…”

Section: Particle Coatingmentioning

confidence: 99%

“…Different polymers were dissolved in dense CO 2 mixed with low-molecular-weight alcohol. Microparticles were suspended in the DG solution, and the system was depressurized through an expanding device . The technique has been applied to the coating of microparticles of proteins, such as lipase and lysozyme .…”

Section: Particle Coatingmentioning

confidence: 99%

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Processing Pharmaceutical Compounds Using Dense Gas Technology

Foster

Mammucari

Dehghani

et al. 2003

Ind. Eng. Chem. Res.

117

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Dense gas techniques, which utilize the properties of fluids in the vicinity of the critical point, are increasingly being used for the processing of pharmaceuticals. Dense gases are unique solvents that can be used for extractions, chromatographic separations, and chemical syntheses because of their liquidlike solvation power and gaslike mass-transfer properties. The processes can be conducted at moderate temperatures and are thus suitable for many heat-labile compounds such as proteins, biocompatible polymers, and pharmaceuticals. The products formed by densegas processes are generally free of residual solvent. Recent applications of dense gas techniques have focused on micronization; crystallization of high-purity particles; sterilization; and drug formulations, including the formation of liposomes and drug coatings. The following review presents examples of drug extraction, separation, synthesis, sterilization, and particle formation and demonstrates the broad application of dense gases for drug formulation purposes in the pharmaceutical industry.

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Section: Particle Coatingmentioning

confidence: 99%

Section: Particle Coatingmentioning

confidence: 99%

Section: Particle Coatingmentioning

confidence: 99%

Section: Particle Coatingmentioning

confidence: 99%

See 2 more Smart Citations

Processing Pharmaceutical Compounds Using Dense Gas Technology

Foster

Mammucari

Dehghani

et al. 2003

Ind. Eng. Chem. Res.

117

View full text Add to dashboard Cite

show abstract

“…However, alternative vapor-phase processing strategies may offer significant cost and performance advantages. Supercritical phase processes, such as rapid expansion of supercritical solution (RESS), gas antisolvent recrystallization (GAS), aerosol solvent extraction system (ASES), supercritical antisolvent technique (SAS) have been investigated and offer the potential to form composite morphologies [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%