Biocompatible hybrid particles of poly(l-lactic acid)@silica

Zalzberg, Lital; Avnir, David

doi:10.1007/s10971-008-1722-3

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…To-date, several approaches have been investigated for fabricating degradable SiO 2 NPs. These include silica nanospheres prepared by incorporation of biodegradable polymers such as poly(L-lactic acid) [12], dissolution of core-shell magnetic mesoporous SiO 2 NPs immersed in phosphate buffered saline (PBS) [13], and the development of highly porous resorbable silica xerogels [14, 15]. In addition, stimuli-triggered SiO 2 NPs have been designed by introducing breakable bonds into SiO 2 NP structure using silane precursors containing such bonds which can be degraded intracellularly in response to enzymes [16], reducing environment [17], pH [18], etc .…”

Section: Introductionmentioning

confidence: 99%

Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery

Moghaddam

Yazdimamaghani

Ghandehari

2018

Journal of Controlled Release

115

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Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO counterparts in terms of their synthesis method, characterization, doxorubicin (DOX) release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells. Transmission electron microscopy (TEM) of the particles indicated that the fabricated HMSiO NPs had an average diameter of 130 ± 5 nm. Thermogravimetric analysis (TGA) revealed that GSH-sensitive particles had approximately 5.3% more weight loss than TEOS HMSiO NPs. Zeta potential of these redox-responsive particles was -23 ± 1 mV at pH 6 in deionized (DI) water. Nitrogen adsorption-desorption isotherm revealed that the surface area of the hollow mesoporous nanoreservoirs was roughly 446 ± 6 m g and the average diameter of the pores was 2.3 ± 0.5 nm. TEM images suggest that the nanoparticles started to lose mass integrity from Day 1. The particles showed a high loading capacity for DOX (8.9 ± 0.5%) as a model drug, due to the large voids existing in the hollow structures. Approximately 58% of the incorporated DOX released within 14 days in phosphate buffered saline (PBS) at pH 6 and in the presence of 10 mM of GSH, mimicking intracellular tumor microenvironment while release from TEOS HMSiO NPs was only c.a. 18%. The uptake of these hollow nanospheres by MCF-7 cells and RAW 264.7 macrophages was evaluated using TEM and confocal microscopy. The nanospheres were shown to accumulate in the endolysosomal compartments after incubation for 24 h with the maximum uptake of c.a. 2.1 ± 0.3% and 5.2 ± 0.4%, respectively. Cytotoxicity of the nanospheres was investigated using CCK-8 assay. Results indicate that intact hollow particles (both GSH-sensitive and TEOS HMSiO NPs) were nontoxic to MCF-7 cells after incubation for 24 h within the concentration range of 0-1000 μg ml. DOX-loaded GSH-sensitive nanospheres containing 6 μg ml of DOX killed c.a. 51% of MCF-7 cells after 24 h while TEOS HMSiO NPs killed c.a. 20% with the difference being statistically significant. Finally, cytotoxicity data in RAW 264.7 macrophages and NIH 3 T3 fibroblasts shows that intact GSH-sensitive HMSiO NPs did not show any toxic effects on these cells with the concentrations equal or <125 μg ml.

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Section: Introductionmentioning

confidence: 99%

Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery

Moghaddam

Yazdimamaghani

Ghandehari

2018

Journal of Controlled Release

115

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“…The hybridization of PLLA with bioactive inorganic materials, such as hydroxyapatite, tricalcium phosphate, bioactive glass, and silica granules, is regarded as an appropriate method for overcoming the weaknesses of PLLA 9–12. Furthermore, a uniform distribution of nano‐sized bioactive ceramics can significantly improve the stiffness and bioactivity of synthetic biopolymers 13–16.…”

Section: Introductionmentioning

confidence: 99%

Fibrous membrane of nano‐hybrid poly‐L‐lactic acid/silica xerogel for guided bone regeneration

Jang

Lee

et al. 2011

J Biomed Mater Res

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Nanofibrous membranes, consisting of a poly(L-lactic acid) (PLLA)-silica xerogel hybrid material, were successfully fabricated from a hybrid sol using the electrospinning technique for guided bone regeneration (GBR) application. These hybrid nanofibers exhibited a homogeneous and continuous morphology, with a nano-sized dispersed silica xerogel phase in the PLLA fiber matrix. The mechanical properties, such as the tensile strength and the elastic modulus, were improved as the silica xerogel content increased up to 40%. All of the hybrid membranes exhibited highly hydrophilic surfaces and good proliferation levels. After culturing for 13 days, the cells that were cultured on the hybrid membranes exhibited a significantly higher ALP activity compared to the pure PLLA membrane. Moreover, the in vivo animal experiments that used the rat calvarial defect model revealed a remarkably improved bone regeneration ability for the hybrid membrane compared to pure PLLA. These results demonstrated the feasibility of these hybrid membranes for efficient GBR.

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“…The grafting of PLLA onto nanomaterial surfaces has been reported [10][11][12][13][14][15][16][17][18][19][20] . For example, Feng et al have reported the grafting of PLLA onto the surface of magnetic multi-walled carbon nanotubes (m-MWCNTs) by in-situ ring-opening polymerization of lactide 17) .…”

mentioning

confidence: 99%

Grafting of Poly(L-lactic acid) onto Carbon Black Surface

正晃¹,

智子²,

健³

et al. 2010

Journal of the Japan Society of Colour Material

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In order to improve the dispersibility of carbon black (CB) in organic solvent, the grafting of poly(L-lactic acid) (PLLA) onto CB surface by (1) polycondensation of L-lactic acid (LLA) in the presence of CB and (2) grafting by the reaction of PLLA with CB surface in the presence of catalyst was investigated. It was found that, during the polycondensation of LLA in the presence of CB, the grafting of PLLA onto CB surface proceeded both in the absence and in the presence of scandium (III) triflate (Sc(OTf)3) as catalyst to give PLLAgrafted CB (1), but the percentage of PLLA grafting onto CB in the presence of Sc(OTf)3 was higher than that in the absence of Sc(OTf)3. In addition, the condensation reaction of surface functional groups on CB with PLLA was successfully achieved in the presence of Sc(OTf)3 to give PLLA-grafted CB (2). The average particle size of CB considerably decreased by grafting of PLLA onto the surface. Therefore, it was concluded that the aggregation of CB particles was considerably destroyed and prevented by grafting of PLLA onto the surface. The PLLA-grafted CBs gave a stable dispersion in polar solvents, such as DMSO and 1,4-dioxane, which are good solvents for PLLA.

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Biocompatible hybrid particles of poly(l-lactic acid)@silica

Cited by 12 publications

References 12 publications

Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery

Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery

Fibrous membrane of nano‐hybrid poly‐L‐lactic acid/silica xerogel for guided bone regeneration

Grafting of Poly(L-lactic acid) onto Carbon Black Surface

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