Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions

Abstract

Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.

Recent Advances in Collagen Mimetic Peptide Structure and Design

“…108 Metal-ion promoted assembly has been used for CMP microcage formation. 109,110 CMPs are readily applicable to these and many other applications in medicine, structural biology, and material development.…”

“…2D nanoscale assemblies from CMPs containing blocks of positive and negative charges have been demonstrated . Metal-ion promoted assembly has been used for CMP microcage formation. , CMPs are readily applicable to these and many other applications in medicine, structural biology, and material development.…”