Formation of Malonaldehyde and Acetaldehyde from the Oxidation of 2‘-Deoxyribonucleosides

Miyake, Takashi; Shibamoto, Takayuki

doi:10.1021/jf990109u

Cited by 14 publications

(12 citation statements)

References 21 publications

(18 reference statements)

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“…Besides, not only polyunsaturated fatty acids are the source of aldehydes. Their small, but measurable amounts could be formed from farnesol [24], squalene [8] or deoxyribose [17].…”

Section: Introductionmentioning

confidence: 99%

A novel test for identifying genes involved in aldehyde detoxification in the yeast. Increased sensitivity of superoxide‐deficient yeast to aldehydes and their metabolic precursors

et al. 2005

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A novel test for the identification of genes involved in aldehyde metabolism is proposed, based on detection of altered sensitivity of the yeast to corresponding alcohols, metabolic precursors of the aldehydes. This attitude enabled to an unexpected detection increased sensitivity of mutants devoid of CuZn-superoxide dismutase (CuZnSOD) to allyl alcohol (precursor of acrolein) and nonenol. We interpret this finding as due to inactivation of some important element of aldehyde detoxification by increased flux of superoxide in DeltaCuZnSOD mutants.

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“…Besides, not only polyunsaturated fatty acids are the source of aldehydes. Their small, but measurable amounts could be formed from farnesol [24], squalene [8] or deoxyribose [17].…”

Section: Introductionmentioning

confidence: 99%

A novel test for identifying genes involved in aldehyde detoxification in the yeast. Increased sensitivity of superoxide‐deficient yeast to aldehydes and their metabolic precursors

et al. 2005

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“…In addition, it has been reported that electrolysis of water takes place at voltages above 2.4 V and that hydroxyl radical (･OH) and hydrogen radical (･H) are generated (18). A major target of ･OH in nucleosides is the deoxyribose moiety, resulting in decomposition of all the nucleosides (19,20). The decomposition of all the nucleosides above 3.0 V may include the formation of ･OH as the reactive species in addition to direct electrical oxidation.…”

Section: Discussionmentioning

confidence: 99%

Degradation of Nucleosides by Direct and Alternating Electric Currents

Suzuki

Yamaguchi

Yokoyama

et al. 2012

Genes and Environment

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Degradation of four nucleosides, 2′-deoxyguanosine, 2′-deoxyadenosine, 2′-deoxycytidine, and thymidine, in potassium phosphate buŠer of pH 7.4 by direct and alternating electric currents was monitored by HPLC. When a direct current of 3 V was applied to the nucleoside solution, all the nucleosides were consumed time-dependently. Results for voltage dependence showed that the nucleosides were decomposed above 0.8 V for 2′-deoxyguanosine, 1.5 V for 2′-deoxyadenosine, and 2.5 V for 2′-deoxycytidine and thymidine. Results of frequency dependence of alternating current at 3 V showed that increasing frequency caused decreasing consumption of all the nucleosides, and that no consumption was observed above 3,000 Hz. The results suggest that accidental ingestion of batteries or electrical shock by domestic power supply may induce alternation of nucleosides.

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“…Formation of acetaldehyde from AA upon UV radiation has been proposed (28). Other degradation products of AA are oxalic acid, keto-threonic acid, reductone A, reductic acid, glycolic acid and glyceric acid as detected by paper chromatography (26).…”

Section: Adverse Effects Of Ionizing Radiationmentioning

confidence: 99%