Formation of lycopene-loaded hydrolysed collagen particles by supercritical impregnation

Aredo, Víctor; Passalacqua, Estela Selaro; Pratavieira, Sebastião; Oliveira, Alessandra Lopes de

doi:10.1016/j.lwt.2019.04.055

Cited by 16 publications

(16 citation statements)

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“…The spectra of lecithin and SLO contained a band appearing around 720–721 cm −1 , which is assigned to the bending (rocking) of (CH 2 ) n − (Guillen & Cabo, 1997); this was not present in the SLO‐incorporated MSM (Figure 5f,i). This behavior was also observed in the formation of particles in supercritical medium using lycopene in sunflower oil (Aredo et al, 2019). This may indicate that some interaction (electrostatic or physical) between lecithin, SLO, and modified starch has occurred in the mixture and caused this band to disappear.…”

Section: Resultssupporting

confidence: 55%

“…This process shows potential for the production of powder food ingredients by avoiding water in the formulation. Researchers have shown advantages in different applications, for example, to impregnate flax oil into spray‐dried/pregelatinized corn starch particles with a load of 6.6 g oil/100 g starch at 300 bar and 80°C (Comin, Temelli, & Saldaña, 2012) or limonene into modified corn starch particles with 86% efficiency at 120 bar and 60°C (Machado, Pelegati, & Oliveira, 2016) or lycopene into hydrolyzed collagen particles with 94% efficiency at 150 bar and 50°C (Aredo, Passalacqua, Pratavieira, & Oliveira, 2019) or oregano essential oil into sorghum starch granules and spray‐dried rice starch spherules, reaching a high antioxidant activity (678 μmol TEAC/g) at 100 bar and 40°C (Almeida et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Water free incorporation of shark liver oil into starch microparticles by supercriticalCO₂impregnation at low temperature

Santos

Aredo

Bazito

et al. 2020

J Food Process Engineering

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Shark liver oil (SLO), rich in squalene, was incorporated into modified starch microparticles (MSMs) by supercritical CO2. This polyunsaturated triterpene presents antitumor and antioxidant activities and, due to the high level of unsaturation in the molecule, it is vulnerable to oxidative attack. This research therefore contributes to the development of methods for impregnating such oil into MSM in order to increase the oil's oxidation stability and prevent its degradation in order to facilitate its use in mixtures with inputs for drugs, foods, and cosmetic. To form SLO‐incorporated MSM, a physical mixture composed of 44% of two MSM with different degrees of hydrophobicity, 11% SLO, 1% lecithin, and 44% ethanol were treated with supercritical CO2 at 120 bar, 40, and 60°C. The SLO‐incorporated MSM preserved MSM morphology and exhibited good incorporation of SLO (74–82%), a high degree of solubilization in water (78–86%), and a low hygroscopicity (4–9%). Stability evaluation revealed that the SLO‐incorporated MSM of Purity Gum Ultra that was formed at 60°C preserved 44% of the initial squalene content. Accordingly, supercritical impregnation represents a practical alternative for SLO impregnation since it is a quick method that does not use water in its formulation and can be done at low temperature. Practical Applications The improvement of drug and food inputs that are thermosensitive in nature and/or of low polarity can be produced by using low‐cost wall material that can make the process more cost effective and more accessible. Particle formation by supercritical CO2 impregnation is a green and nonaggressive process for bioactive compounds that allows the design of innovative food products. Moreover, the fact that the use of modified starches for wall materials, which are already used safely by the food and pharmaceutical industries, makes the process and derived products more reliable. In this sense, the incorporation of shark liver oil (rich is squalene) in modified starch microparticles by supercritical impregnation could be a practical alternative for powdered food industries.

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Section: Resultssupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Water free incorporation of shark liver oil into starch microparticles by supercriticalCO₂impregnation at low temperature

Santos

Aredo

Bazito

et al. 2020

J Food Process Engineering

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“…When associated with β-lactoglobulin at pH 7.0, lycopene presented λex of 295 nm [ 29 ]. Different fluorescence emissions were also observed for lycopene-loaded hydrolyzed collagen particles, which presented maximum fluorescence λex at 627 nm for red, maximum λex at 592 nm for orange, maximum λex at 522 nm for green, and maximum λex at 478 nm for light blue [ 30 ].…”

Section: Chemical Characterizationmentioning

confidence: 99%

Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting

et al. 2022

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The purpose of this review was to collect relevant chemical data about lycopene and its isomers, which can be extracted using different non-polar or polar aprotic solvents by SC-CO2 or biosynthesis as a friendly technique. Lycopene and other carotenoids can be identified and quantified by UV–Vis and HPLC using a C18 or C30 column, while their characterization is possible by UV–Vis, Fluorescence, FTIR, MS, NMR, and DSC assays. Among these techniques, the last four can compare lycopene isomers and identify cis or all-trans-lycopene. FTIR, MS, and NMR techniques are more suitable for the verification of the purity of lycopene extracts due to the signal complexity generated for each isomer, which enables identification by subtle differences. Additionally, some biological activities of lycopene isolated from red vegetables have already been confirmed, such as anti-inflammatory, antioxidant, and cytotoxic activity against cancer cells, probably by activating several pathways. The encapsulation of lycopene in nanoparticles demonstrated an improvement in oral delivery, and ex vivo assessments determined that these nanoparticles had better permeation and low cytotoxicity against human cells with enhanced permeation. These data suggest that lycopene has the potential to be applied in the food and pharmaceutical industries, as well as in cosmetic products.

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“…The particles were characterised according to their internal physical structure using a confocal fluorescence microscope (LSM 780, Zeiss, Heidelberg, GE) with two-photon excitation (laser titanium: 800 nm sapphire, 80 MHz, 100 fs pulse), an objective lens (20x; 0.8NA; wd =0.5 mm (air)) and high-sensitivity GaAsP detectors for spectral imaging at 400-700 nm (AREDO et al, 2019). This analyse was carried out by the optics group of the São Carlos Institute of Physics/USP.…”

Section: Internal Physical Structurementioning

confidence: 99%

“…It consists of the contact of protein particles with a lipid material solubilised in supercritical CO2, which remains on the surface of the particles after depressurisation of the system . In this context, the application of this process in pigment-loaded hydrolysed collagen powder, which is an emerging carrier system formed by supercritical CO2 technology (AREDO et al, 2019;, could be useful for design new powder ingredients.…”

Section: Introductionmentioning

confidence: 99%

Formation of pigment-loaded lipid particles using supercritical CO>sub<2>/sub<

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Formation of lycopene-loaded hydrolysed collagen particles by supercritical impregnation

Cited by 16 publications

References 40 publications

Water free incorporation of shark liver oil into starch microparticles by supercriticalCO₂impregnation at low temperature

Water free incorporation of shark liver oil into starch microparticles by supercriticalCO₂impregnation at low temperature

Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting

Formation of pigment-loaded lipid particles using supercritical CO>sub<2>/sub<

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Formation of lycopene-loaded hydrolysed collagen particles by supercritical impregnation

Cited by 16 publications

References 40 publications

Water free incorporation of shark liver oil into starch microparticles by supercriticalCO2impregnation at low temperature

Water free incorporation of shark liver oil into starch microparticles by supercriticalCO2impregnation at low temperature

Bio-Availability, Anticancer Potential, and Chemical Data of Lycopene: An Overview and Technological Prospecting

Formation of pigment-loaded lipid particles using supercritical CO>sub<2>/sub<

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Water free incorporation of shark liver oil into starch microparticles by supercriticalCO₂impregnation at low temperature

Water free incorporation of shark liver oil into starch microparticles by supercriticalCO₂impregnation at low temperature