Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle

Machmudah, Siti; Winardi, Sugeng; Diono, Wahyu; Kanda, Hideki; Goto, Motonobu

doi:10.1021/acsomega.9b04495

Cited by 25 publications

(5 citation statements)

References 44 publications

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“…The absence of characteristic bands of curcumin in PEO-EC-Co-Cur@PVP may indicate the PEO-EC-Co-PVP polymer blend as a good carrier for the encapsulation of curcumin molecules. Favorable hydrogen bonding between curcumin and PVP is further proven with the disappearance of the sharp peak of phenolic stretching of curcumin and the shift of carbonyl stretching vibration of PVP into a lower wavenumber …”

Section: Resultsmentioning

confidence: 93%

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Enhancement of Release and Solubility of Curcumin from Electrospun PEO–EC–PVP Tripolymer-Based Nanofibers: A Study on the Effect of Hydrogenated Castor Oil

et al. 2022

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This study reveals the state-of-the-art fabrication of a tripolymer-based electrospun nanofiber (NF) system to enhance the release, solubility, and transdermal penetration of curcumin (Cur) with the aid of in situ release of infused castor oil (Co). In this regard, Cur-loaded Co-infused polyethylene oxide (PEO), ethyl cellulose (EC), and polyvinyl pyrrolidone (PVP) tripolymer-based NF systems were developed to produce a hybridized transdermal skin patch. Weight percentages of 1–4% Cur and 3–10% of Co were blended with PEO–EC–PEO and PEO–EC–PVP polymer systems. The prepared NFs were characterized by SEM, TEM, FT-IR analysis, PXRD, differential scanning calorimetry (DSC), and XPS. Dialysis membranes and vertical Franz diffusion cells were used to study the in vitro drug release and transdermal penetration, respectively. The results indicated that maintaining a Cur concentration of 1–3 wt % with 3 wt % Co in both PEO–EC–Co–Cur@PEO and PEO–EC–Co–Cur@PVP gave rise to nanofibers with lowered diameters (144.83 ± 48.05–209.26 ± 41.80 nm and 190.20 ± 59.42–404.59 ± 45.31 nm). Lowered crystallinity observed from the PXRD patterns and the disappearance of exothermic peaks corresponding to the melting point of Cur suggested the formation of an amorphous NF structure. Furthermore, the XPS data revealed that the Cur loading will possibly take place at the inner interface of PEO–EC–Co–PEO and PEO–EC–Co–PVP NFs rather than on the surface. The beneficiary role of Co on the release and dermal penetration of Cur was further confirmed from the respective release data which indicated that PEO–EC–Co–Cur@PEO would lead to a rapid release (4–5 h), while PEO–EC–Co–Cur@PVP would lead to a sustained release over a period of 24 h in the presence of Co. Transdermal penetration of the released Cur was further evidenced with the development of color in the receiver compartment of the diffusion cell. DPPH results further corroborated that a sustained antioxidant activity is observed in the released Cur where the free-radical scavenging activity is intact even after subjecting to an electrospinning process and under extreme freeze–thaw conditions.

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Section: Resultsmentioning

confidence: 93%

“…Favorable hydrogen bonding between curcumin and PVP is further proven with the disappearance of the sharp peak of phenolic stretching of curcumin and the shift of carbonyl stretching vibration of PVP into a lower wavenumber. 59 2.3. XRD Analysis of the NF Systems.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Release and Solubility of Curcumin from Electrospun PEO–EC–PVP Tripolymer-Based Nanofibers: A Study on the Effect of Hydrogenated Castor Oil

et al. 2022

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“…xanthorrhiza rhizome extract into an aqueous medium was affected by the content of the PVP polymer in the particle products, where the release rate of C. xanthorrhiza rhizome extract increased with the increasing PVP polymer amount in the particle products. , Figure illustrates the UV–vis spectral profile of the collected particle product dissolution from the feed solution comprising C. xanthorrhiza rhizome extract and PVP with a ratio of 1:10 in distilled water.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique

et al. 2022

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Fine particles comprising Curcuma xanthorrhiza Roxb (C. xanthorrhiza) rhizome extract were successfully generated using a supercritical carbon dioxide (SCCO2) antisolvent technique. The SCCO2 antisolvent process was performed at 40 °C with 8–16 MPa operating pressures. The CO2 and feed solution flow rates were 15 and 0.25 mL min–1, respectively. The mixture of C. xanthorrhiza rhizome extract and a polyvinylpyrrolidone (PVP) polymer in acetone–ethanol was used as a feed solution. The collected particle products seemed to possess spherical and spherical-like morphologies with a diameter of less than 500 nm. The infrared spectroscopy analysis showed that the structural properties of C. xanthorrhiza rhizome extract did not change after treatment with the SCCO2 antisolvent. Furthermore, the addition of the PVP polymer in the C. xanthorrhiza rhizome extract particle products may improve their dissolution significantly in an aqueous solution medium.

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“…The former can also prevent the agglomeration of the particle product. Furthermore, the intermolecular interaction between curcumin and PVP can lead to a higher thermal stability of curcumin via carboxyl and carbonyl conjugations [ 58 ]. Altogether, the addition of PVP to curcumin may improve the solubility and stability of curcumin, resulting in better pharmacokinetic properties.…”

Section: Discussionmentioning

confidence: 99%

Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway

Jantarawong,

Swangphon,

Lauterbach

et al. 2023

Pharmaceutics

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Curcuminoids, namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are the major active compounds found in Curcuma longa L. (turmeric). Although their suppressive effects on bone resorption have been demonstrated, their pharmacokinetic disadvantages remain a concern. Herein, we utilized solid dispersion of a curcuminoid-rich extract (CRE), comprising such curcuminoids, to prepare CRE-SD; subsequently, we performed liposome encapsulation of the CRE-SD to yield liposomal CRE-SD. In vitro release assessment revealed that a lower cumulative mass percentage of CRE-SD was released from liposomal CRE-SD than from CRE-SD samples. After culture of murine RANKL-stimulated RAW 264.7 macrophages, our in vitro examinations confirmed that liposomal CRE-SD may impede osteoclastogenesis by suppressing p65 and IκBα phosphorylation, together with nuclear translocation and transcriptional activity of phosphorylated p65. Blind docking simulations showed the high binding affinity between curcuminoids and the IκBα/p50/p65 protein complex, along with many intermolecular interactions, which corroborated our in vitro findings. Therefore, liposomal CRE-SD can inhibit osteoclastogenesis via the canonical NF-κB signaling pathway, suggesting its pharmacological potential for treating bone diseases with excessive osteoclastogenesis.

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Formation of Fine Particles from Curcumin/PVP by the Supercritical Antisolvent Process with a Coaxial Nozzle

Cited by 25 publications

References 44 publications

Enhancement of Release and Solubility of Curcumin from Electrospun PEO–EC–PVP Tripolymer-Based Nanofibers: A Study on the Effect of Hydrogenated Castor Oil

Enhancement of Release and Solubility of Curcumin from Electrospun PEO–EC–PVP Tripolymer-Based Nanofibers: A Study on the Effect of Hydrogenated Castor Oil

Enhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique

Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway

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