“…Alginate has been used effectively to deliver human, murine, and lapine BMDMSC to heal musculoskeletal connective tissues, particularly for the induction of chondrogenic differentiation. 10,26,[28][29][30][31][32] In these studies, cells had been preconditioned via exposure to one or more factors previously demonstrated to induce osteogenic and/or chondrogenic differentiation, for example, dexamethasone, ascorbate-2-phosphate, BMP-2, BMP-9, transforming growth factor b1 (TGF-b1), and/or TGF-b3. The ability of an alginate system to support transduced stem cells and accelerate osteogenic differentiation in suspended, isolated cells in vitro has not been reported.…”