Formation and dissolution of phospholipid domains with varying textures in hybrid lipo-polymersomes

Nam, Jin; Vanderlick, T. Kyle; Beales, Paul A.

doi:10.1039/c2sm25646k

Cited by 90 publications

(144 citation statements)

References 48 publications

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“…Studies reported to date on hybrid vesicles have not yielded detailed information on the efficiency of hybrid vesicle formation in bulk solution [14][15][16][17][18][19][20][21]. Flow cytometry has been demonstrated as a useful tool to study vesicle populations [23].…”

Section: Resultsmentioning

confidence: 99%

“…It may be concluded that liposomes and polymersomes have their own particular benefits and limitations, which is why the preparation of hybrid membranes consisting of phospholipids and block copolymers is attracting increasing attention [14][15][16][17][18][19][20][21]. In this way, the robustness and chemical versatility of polymersomes can be combined with the softness and biocompatibility of liposomes.…”

Section: Introductionmentioning

confidence: 99%

“…Using fluorescence microscopy, several recent studies observed the formation of hybrid lipid/polymer giant unilamellar vesicles (GUVs) of 10-50 µm, prepared via electroformation, over a certain range of compositions [14][15][16][17][18]. Parameters controlling the self-assembly of lipids with block copolymers (forming hybrids GUVs), and the resulting phase behavior, are the mole fraction of the constituting amphiphiles, as well as the nature of the amphiphiles themselves [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Parameters controlling the self-assembly of lipids with block copolymers (forming hybrids GUVs), and the resulting phase behavior, are the mole fraction of the constituting amphiphiles, as well as the nature of the amphiphiles themselves [14][15][16][17]. Nam et al [15] observed efficient mixing of PB 46 -PEO 30 [polybutadiene-b-poly(ethylene oxide)] and POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine) to occur only at polymer concentrations above 65%, while Schulz et al [17] found hybrid GUVs to form at all investigated molar ratios of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and polyisobutylene-b-PEO.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

et al. 2013

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Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadieneb-poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation. OPEN ACCESSPolymers 2013, 5 1103

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

et al. 2013

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“…These recently studied nanostructures (consisting of both polymers and lipids) not only have excellent robustness and tunable structural properties of polymersomal formulations but also retain the liposomes’ biocompatibility and biofunctionality [84,85]. A recent study demonstrates that targeting cancer-cell receptors can be achieved more efficiently using HLPs compared with polymersomes [86].…”

Section: Hybrid Lipo-polymersomesmentioning

confidence: 99%

Polymersome-Based Drug-Delivery Strategies for Cancer Therapeutics

2015

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Polymersomes are stable vesicles prepared from amphiphilic polymers and are more stable compared with liposomes. Although these nanovesicles have many attractive properties for in vitro/in vivo applications, liposome-based drug delivery systems are still prevalent in the market. In order to expedite the translational potential and to provide medically valuable formulations, the polymersomes need to be biocompatible and biodegradable. In this review, recent developments for biocompatible and biodegradable polymersomes, including the design of intelligent, targeted, and stimuli-responsive vesicles are summarized.

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Nanostructured Lipid‐Based Films for Substrate‐Mediated Applications in Biotechnology

Kang

Tuteja

Centrone

et al. 2018

Adv Funct Materials

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Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multi-layered membranes on solid supports only recently begun drawing scientists’ attention. New studies on lipid films show that the stacking of multiple bilayers on a solid support yields interestingly complex features to these systems. Namely, multiple layers exhibit cooperative structural and dynamic behavior. In addition, the materials enable compartmentalization, templating, and enhanced release of several molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nano-scale order and orientation that is tunable in response to a changing environment. Herein, we summarize current and pertinent understanding of lipid-based film research focusing on how unique structural characteristics enable the emergence of new applications in biotechnology including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. Our very recent contributions to lipid-based films, focusing on the structural characterization at the meso, nano, and molecular-scale, using Small-Angle X-ray Scattering, Atomic Force Microscopy, Photothermal Induced Resonance, and Solid-State NMR will be also highlighted.

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Formation and dissolution of phospholipid domains with varying textures in hybrid lipo-polymersomes

Cited by 90 publications

References 48 publications

Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

Polymersome-Based Drug-Delivery Strategies for Cancer Therapeutics

Nanostructured Lipid‐Based Films for Substrate‐Mediated Applications in Biotechnology

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