Formation and characteristics of aqueous two-phase systems formed by a cationic surfactant and a series of ionic liquids

Wei, Xilian; Wang, Xiuhong; Ping, Ali; Du, Panpan; Sun, Dezhi; Zhang, Qingfu; Liu, Jie

doi:10.1016/j.jchromb.2013.09.006

Cited by 16 publications

(15 citation statements)

References 40 publications

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“…The behavior was inconsistent on changing the IL anion. For example, increasing the imidazolium alkyl chain length increased phase separation for a series of BF4- ILs and decreased for the same series as Br − ILs (Wei et al, 2013). IL-ATPS and their applications were also demonstrated for dodecyl trimethylammonium-based (Flieger et al, 2013), functionalized amino acid and nucleotide ILs, for example glycine and guanidine (Wu et al, 2013; Zeng et al, 2013; Ding et al, 2014; Yao et al, 2016).…”

Section: Types and Properties Of Il-atpsmentioning

confidence: 99%

“…IL-ATPSs can be formed with conventional kosmotropic salts (potassium sulfate, citrate, ammonium sulfate), common salts (citric, fumaric, succinic, and tartaric acid sodium salts), amino acids, PEG and surfactants (3-p-nonylphenoxy-2-hydroxypropy trimethyl ammonium bromide, NPTAB and sodium dodecyl sulfonate, SDS), and combinations (Wu C. et al, 2011; Passos et al, 2012; Wei et al, 2013; Abdolrahimi et al, 2015; Dai et al, 2015; Pereira et al, 2015). The size of the biphasic region can be controlled by functionalizing the PEG terminal groups with –OH, –OMe, or –NH 2 to change the hydrogen bonding donor or acceptor.…”

Section: Types and Properties Of Il-atpsmentioning

confidence: 99%

“…Improvements in the extraction performance for a hydrophobic molecule, tryptophan was demonstrated in citrate-based IL-ATPSs for use in continuous extraction of amino acids. The incorporation of surfactants decreased the viscosities of both phases and flipped the IL-rich phase to the bottom phase as a result of density changes (Wei et al, 2013; Dai et al, 2015).…”

Section: Types and Properties Of Il-atpsmentioning

confidence: 99%

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Ionic Liquid Aqueous Two-Phase Systems From a Pharmaceutical Perspective

McQueen

Lai

2019

Front. Chem.

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Aqueous Two-Phase Systems (ATPSs) have been extensively studied for their ability to simultaneously separate and purify active pharmaceutical ingredients (APIs) and key intermediates with high yields and high purity. Depending on the ATPS composition, it can be adapted for the separation and purification of cells, nucleic acids, proteins, antibodies, and small molecules. This method has been shown to be scalable, allowing it to be used in the milliliter scale for early drug development to thousands of liters in manufacture for commercial supply. The benefits of ATPS in pharmaceutical separations is increasingly being recognized and investigated by larger pharmaceutical companies. ATPSs use identical instrumentation and similar methodology, therefore a change from traditional methods has a theoretical low barrier of adoption. The cost of typical components used to form an ATPS at large scale, particularly that of polymer-polymer systems, is the primary challenge to widespread use across industry. However, there are a few polymer-salt examples where the increase in yield at commercial scale justifies the cost of using ATPSs for macromolecule purification. More recently, Ionic Liquids (ILs) have been used for ATPS separations that is more sustainable as a solvent, and more economical than polymers often used in ATPSs for small molecule applications. Such IL-ATPSs still retain much of the attractive characteristics such as customizable chemical and physical properties, stability, safety, and most importantly, can provide higher yield separations of organic compounds, and efficient solvent recycling to lower financial and environmental costs of large scale manufacturing.

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Section: Types and Properties Of Il-atpsmentioning

confidence: 99%

Section: Types and Properties Of Il-atpsmentioning

confidence: 99%

Section: Types and Properties Of Il-atpsmentioning

confidence: 99%

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Ionic Liquid Aqueous Two-Phase Systems From a Pharmaceutical Perspective

McQueen

Lai

2019

Front. Chem.

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“…However, the combinations of polyethylene glycol (PEO)/salt (e.g., citrate, phosphate and sulphate) and PEO/dextran are the most commonly utilised systems for liquidliquid extraction [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Partitioning of Geotrichum candidum Lipase from fermentative crude extract by aqueous two-phase system of polyethylene glycol and sodium citrate

Mazzeu

Ramos

Cavalcanti

et al. 2015

Separation and Purification Technology

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“…The applications are, however, recognized only at some threshold concentrations (called as critical micellar concentration or hemimicellar concentration, [4,5]) beyond which the clustering phenomenon occurs. A large number of factors such as, surfactant structure [6][7][8][9], solvent behaviour [10][11][12], presence of additives like electrolytes [13][14][15], hydrophobic solute [16,17] and others [18][19][20][21], temperature of the systems [22][23][24][25] etc. depict the extent and spontaneity of the clustering phenomena.…”

Section: Introductionmentioning

confidence: 99%