Formation and Absorption of Cerebrospinal Fluid in Man

The formation of cerebrospinal fluid: Nearly a hundred years of interpretations and misinterpretations

“…1. except for Nos. 2 and 5) approximately 1.5 -3-fold higher than the values reported in the literature so far (Cutler et al, 1968;Lorenzo et al, 1970;Masserman, 1934;Pollay, 1972;Rubin et al, 1966;Sjöqvist, 1937). Such significant deviation in V f determination within the MR imaging method itself (from 0 to 1.04 ml/min) and the deviation in relation to other methods are probably the consequence of various techniques being used to measure the CSF flow although the values should in both cases be the same regardless of the different techniques used.…”

“…1; Nos. 2 and 5), calculated CSF formation was zero, and in the remaining studies V f values were higher than the values measured using the other methods (Cutler et al, 1968;Lorenzo et al, 1970;Masserman, 1934;Pollay, 1972;Rubin et al, 1966;Sjöqvist, 1937). It is important to emphasize that in reality these differences are even greater considering that the choroid plexus of the fourth brain ventricle is not included in the study using the MR imaging method to determine V f as it is outside the field of measurement.…”

“…By using the ventriculo-spinal perfusion in children ( 125 I albumine), it has been detected that the creation is 4-5 times larger than normal (1.43 ml/min), while the calculated absorption was within normal range, 0.59 ml/min (Eisenberg et al, 1974). The normal value is the result which Cutler et al (1968) have observed in children without CSF pathway obstruction, and in those that had communicating hydrocephalus, obtained by ventriculo-lumbar perfusion (creation 0.30 ml/min; absorption 0.61 ml/min). In this method, the quantity of CSF secretion is determined based on the dilution of the marker substance (see section 3 -Methods of measuring cerebrospinal fluid formation).…”

“…The rate of CSF formation in humans is about 0.3-0.4 ml/min (Cutler et al, 1968;Masserman, 1934;Pollay, 1972;Rubin et al, 1966;11 Sjöqvist, 1937), which means that the total production per day is about 430-580 ml. Based on the total CSF volume of 160 ml in the CSF system, it takes about 6 and a half to 9 hours to replace this volume of fluid.…”

“…Since CSF formation is an active process, the CSF formation rate should not be significantly altered by moderate changes in intracranial pressure (Cutler et al, 1968;Heisey et al, 1962;Pollay et al, 1983;Rubin et al, 1966;Sklar et al, 1980). If CSF pathways are blocked and active secretion is independent of hydrostatic pressure, the CSF secretion should continue with an accumulation of CSF, an increase in intracranial pressure, the dilatation of the brain ventricles, and eventually result in hydrocephalus.…”