Cerebrospinal Fluid and Cranial Sinus Pressures

Sahar, Abraham

doi:10.1001/archneur.1970.00480290033004

Cited by 19 publications

(4 citation statements)

References 23 publications

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“…For this to be the case, dural sinus pressure must remain constant while the intracranial CSF pressure increases, which has been demonstrated to be true for cats and dogs (Weed and Flexner, 1933;Weed, 1935;Bering, 1958;Shulman, Yarnell, and Ransohoff, 1964;Shulman, 1965), as well as most adult humans so tested (author's unpublished data). But other reports leave little doubt that in some infants with hydrocephalus (Shulman and Ransohoff, 1965;Norrell, Wilson, Howieson, Megison, and Bertan, 1969), adults with subdural haematomas (Osterholm, 1970) and in hydrocephalic animals (Shulman et al, 1964; and Ransohoff, 1970), the dural sinus pressure does…”

Section: Discussionmentioning

confidence: 98%

Resistance to drainage of cerebrospinal fluid: clinical measurement and significance

Martins

1973

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 98%

Resistance to drainage of cerebrospinal fluid: clinical measurement and significance

Martins

1973

Journal of Neurology, Neurosurgery & Psychiatry

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“…Later, Adolph et al (1967) demonstrated in an experimental study, where the effects of right atrial and left ventricular cardiac events were dissociated, that., depending on systemic haemodynamic conditions, CSF pressm'e waves are either venous or arterial in type. 1966, Guthrie et al 1970, Sahar et al 1970, Lowell et al 1971, Kaste et M. 1972, no simultaneous recordings of cerebrospinal pressure waves and cerebral venous pressure variations under physiological conditions were reported in previous neurosurgieal and physiological literature. 1964, Langfitt eta].…”

Section: Discussionmentioning

confidence: 99%

“…Special interest is focussed on the pressure relationship between CSFP and SSP, because' the pressure gradient between the subarachnoid space and the sagittal sinus apparently plays an important role in CSF resorption (Mortensen et al 1934, Weed 1935, Bering et al 1959, 1963, Welch et al 1960, Shulman et al 1964, Davson 1970, Sahar et al 1970. Special interest is focussed on the pressure relationship between CSFP and SSP, because' the pressure gradient between the subarachnoid space and the sagittal sinus apparently plays an important role in CSF resorption (Mortensen et al 1934, Weed 1935, Bering et al 1959, 1963, Welch et al 1960, Shulman et al 1964, Davson 1970, Sahar et al 1970.…”

Section: Introductionmentioning

confidence: 99%

Effects of arterial hypoxaemia, hypercapnia, and changes in cerebral perfusion pressure on mean cerebrospinal fluid and sagittal sinus pressure

1974

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In 20 anaesthetised, artificially ventilated dogs the influence of arterial hypoxaemia, hypereapnia, and decreased systemic arterial blood pressure on mean cerebrospinal fluid pressure and on the pressure in the superior sagittal sinus was studied. Below a YaO~ of 40 Torr and above a PaCO2 of 70 Torr, CSFP was significantly increased. The pressure rise in the ~oreular, however, was only moderate.Simultaneous CBF measurements showed marked cerebral hyperaemia to be the essential cause of the increase in CSFP.In deep normovolaemie arterial hypotension (MABP below 50 mm Hg), CSFP and SSP were significantly decreased. CBF fell sharply by about 50% compared to the resting values. In arterial normotension and under nermocapnie-normoxie conditions, a pressure difference of about 3 mm Hg existed between CSFP and SSP. This pressure difference increased in hypoxia and hypercapnia and fell in arterial hypotension below the "opening-pressure" of the arachnoid villi. An artificially induced rise of CSFP in another 5 experimental animals was reflected to a minor degree in the toreular pressure. ]LIowever, during rapid reduction of raised intracranial pressure, a transient, but marked pressure rise occurred in the toreular, persisting as long as systemic arterial blood pressure was increased (Cushing response). This is explained by post-compression cerebral hyperaemia and by the undamped transmission of the hypertensive arterial pressure to the dilated cerebral vessels. The origin of the rapid CSF pulse waves was studied in simultaneous recordings of intraeranial CSF, cerebral venous, systemic arterial and central venous pressure, and it was shown that the height of CSFP is dependent on MABP, whereas the contour of the CSF pulse waves is shaped by rapid changes of cerebral blood volume in the post-capillary eerebral vascular bed.

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“…It is the outflow for venous blood and the site of reabsorption for CSF. It maintains a pressure lower than the ICP under most physiological conditions [22][23][24][25][26][27]. In addition, in the model the spinal thecal sac compartment is interconnected to the intracranial space through the link between the cranial and spinal subarachnoid spaces.…”

Section: Methodsmentioning

confidence: 99%

330 Interactions of Brain, Blood, and CSF: A Novel Mathematical Model of Cerebral Edema

Doron¹,

Zadka²,

Barnea³

et al. 2023

Neurosurgery

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and total length-of-care, respectively. Multivariable Cox proportional hazards modeling was used to assess the effect of Cognitive Symptom Ratio (CSR), defined as cognitive symptom score divided by Post-Concussion Symptom Scale (PCSS) score, on RTL duration.RESULTS: Of 653 athletes evaluated within 5 days of their concussion, 343 patients were included in the final cohort. Athletes reported a median initial PCSS score of 21 (IQR 6-37) and a median cognitive symptom score of 4 (IQR 0-9). Most patients endorsed some degree of "difficulty concentrating" (n = 212, 61.3%). Median CSR was 0.18 (IQR 0.00-0.27). On multivariable regression analysis, higher CSR was associated with prolonged RTL duration (HR 0.30, 95% CI 0.13-0.69, p = .004). When initial PCSS was added to the model, the previously significant association between CSR and RTL was no longer significant (HR 0.67, 95% CI 0.29-1.59, p = .367). When dichotomized based on frequency distribution, a higher proportion of low CSR patients achieved RTL by 7 days post-injury (82.2% vs. 69.9%, p = .007), a difference not seen at 14 days (92.2% vs. 87.3%, p = .133).CONCLUSIONS: Acute cognitive symptom scores can predict who may be at increased risk for prolonged RTL and which patients with normal PCSS scores may experience difficulties once resuming school activities.

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Cerebrospinal Fluid and Cranial Sinus Pressures

Abstract: PRESSURE has repeatedly been demonstrated to be an important factor in bulk absorption of cerebrospinal fluid (CSF). The dependence of absorption on pressure was shown to be linear above a critical threshold pressure and thereafter over a wide pressure range.1-4 A similar, although

Cited by 19 publications

References 23 publications

Resistance to drainage of cerebrospinal fluid: clinical measurement and significance

Resistance to drainage of cerebrospinal fluid: clinical measurement and significance

Effects of arterial hypoxaemia, hypercapnia, and changes in cerebral perfusion pressure on mean cerebrospinal fluid and sagittal sinus pressure

330 Interactions of Brain, Blood, and CSF: A Novel Mathematical Model of Cerebral Edema

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