Formate production from methanol by formaldehyde dismutase coupled with a methanol oxidation system

Kato, Nobuo; Mizuno, Sumiko; Imada, Yukio; Shimao, Masayuki; Sakazawa, Chikahiro

doi:10.1007/bf00451633

Cited by 8 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Formaldehyde dismutase from Pseudomonas putfda catalyzes the dismutation of various aldehydes (including formaldehyde), leading to the formation of equimolar amounts of the corresponding alcohols and acids. An enzymatic process for the production of formate from methanol involving a combination of methanol oxidase and formaldehyde dismutase was developed (Kato et al, 1988) (Figure 5). In this process, methanol is flrst oxidized to formaldehyde, which is converted to formate and methanol by the formaldehyde dismutase.…”

Section: Chloroperoxidasementioning

confidence: 99%

Interrelations of chemistry and biotechnology-VI. Microbial production of commodity chemicals (Technical Report)

Nagasawa¹,

Yamada²

1995

Pure and Applied Chemistry

View full text Add to dashboard Cite

show abstract

Section: Chloroperoxidasementioning

confidence: 99%

Interrelations of chemistry and biotechnology-VI. Microbial production of commodity chemicals (Technical Report)

Nagasawa¹,

Yamada²

1995

Pure and Applied Chemistry

View full text Add to dashboard Cite

show abstract

Peroxygenase‐katalysierte Oxyfunktionalisierung angetrieben durch Methanoloxidation

Fernández‐Fueyo

Baraibar

et al. 2015

Angewandte Chemie

View full text Add to dashboard Cite

Peroxygenasen katalysieren eine Vielzahl stereoselektiver Oxyfunktionalisierungen unter Verwendung von Wasserstoffperoxid als einzigem Oxidationsmittel. Allerdings werden Peroxygenasen auch durch H2O2 irreversibel inaktiviert. Für robuste Peroxygenase‐Reaktionen ist also eine effiziente In‐situ‐Bereitstellung von H2O2 unabdingbar. Hier beschreiben wir eine neuartige Enzymkaskade zur reduktiven Aktivierung von Luftsauerstoff unter Verwendung von Methanol als stöchiometrischem Reduktionsmittel. Am Beispiel der stereoselektiven Hydroxylierung von Ethylbenzol zu (R)‐1‐Phenylethanol zeigen wir die effiziente Nutzung aller in Methanol gespeicherten Reduktionsäquivalente zur reduktiven Aktivierung von O2.

show abstract

Peroxygenase‐Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol

et al. 2015

View full text Add to dashboard Cite

Peroxygenases catalyze a broad range of (stereo)selective oxyfunctionalization reactions. However, to access their full catalytic potential, peroxygenases need a balanced provision of hydrogen peroxide to achieve high catalytic activity while minimizing oxidative inactivation. Herein, we report an enzymatic cascade process that employs methanol as a sacrificial electron donor for the reductive activation of molecular oxygen. Full oxidation of methanol is achieved, generating three equivalents of hydrogen peroxide that can be used completely for the stereoselective hydroxylation of ethylbenzene as a model reaction. Overall we propose and demonstrate an atom-efficient and easily applicable alternative to established hydrogen peroxide generation methods, which enables the efficient use of peroxygenases for oxyfunctionalization reactions.

show abstract

Formate production from methanol by formaldehyde dismutase coupled with a methanol oxidation system

Cited by 8 publications

References 13 publications

Interrelations of chemistry and biotechnology-VI. Microbial production of commodity chemicals (Technical Report)

Interrelations of chemistry and biotechnology-VI. Microbial production of commodity chemicals (Technical Report)

Peroxygenase‐katalysierte Oxyfunktionalisierung angetrieben durch Methanoloxidation

Peroxygenase‐Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol

Contact Info

Product

Resources

About