Formal thought disorder in schizophrenia and bipolar disorder: A systematic review and meta-analysis

Yalınçetin, Berna; Bora, Emre; Binbay, Tolga; Ulaş, Halis; Akdede, Berna Binnur; Alptekın, Köksal

doi:10.1016/j.schres.2016.12.015

Cited by 59 publications

(50 citation statements)

References 73 publications

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“…Subsequent investigations confirmed the presence of disordered thinking not only in SZ, but also in affective and other psychotic conditions and in some organic brain diseases. [31][32][33][34][35][36][37][38][39][40][41][42][43] There is now agreement that TD is a transdiagnostic symptom, even though different clinical disorders have distinct TD profiles and some features of TD are nonspecific. [38][39][40][41][42][44][45][46] Andreasen and colleagues, eg, found that poverty of speech and content were more characteristic of SZ than of mania.…”

Section: Introductionmentioning

confidence: 99%

Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls

Morgan

Coleman

Ülgen

et al. 2017

Schizophrenia Bulletin

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Thought disorder (TD) has long been associated with schizophrenia (SZ) and is now widely recognized as a symptom of mania and other psychotic disorders as well. Previous studies have suggested that the TD found in the clinically unaffected relatives of SZ, schizoaffective and bipolar probands is qualitatively similar to that found in the probands themselves. Here, we examine which quantitative measures of TD optimize the distinction between patients with diagnoses of SZ and bipolar disorder with psychotic features (BP) from nonpsychiatric controls (NC) and from each other. In addition, we investigate whether these same TD measures also distinguish their respective clinically unaffected relatives (RelSZ, RelBP) from controls as well as from each other. We find that deviant verbalizations are significantly associated with SZ and are co-familial in clinically unaffected RelSZ, but are dissociated from, and are not co-familial for, BP disorder. In contrast, combinatory thinking was nonspecifically associated with psychosis, but did not aggregate in either group of relatives. These results provide further support for the usefulness of TD for identifying potential non-penetrant carriers of SZ-risk genes, in turn enhancing the power of genetic analyses. These findings also suggest that further refinement of the TD phenotype may be needed in order to be suitable for use in genetic studies of bipolar disorder.

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Section: Introductionmentioning

confidence: 99%

Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls

Morgan

Coleman

Ülgen

et al. 2017

Schizophrenia Bulletin

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“…bipolar affective disorder) because there are significant differences across diagnoses on course, quality and temporal stability of these experiences. [53][54][55]…”

Section: Study Selectionmentioning

confidence: 99%

Disorganisation, thought disorder and socio-cognitive functioning in schizophrenia spectrum disorders

et al. 2018

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“…In the present study, we aim to clarify whether previous findings of factor structure can be replicated in a large and representative sample of participants with SCZD. Although BD shares clinical features with SCZD such as positive psychotic symptoms (Goghari et al, 2013;Yalincetin et al, 2017), negative symptoms (Strauss et al, 2016), depression (Upthegrove et al, 2017), and impaired neurocognition (Simonsen et al, 2011), there are several limitations associated with the use of measurement scales in populations for which they were not designed. With respect to the IS, it may not reflect the symptomology or course of illness among individuals with other severe mental disorders, such as BD.…”

Section: Introductionmentioning

confidence: 99%

Validity of the Birchwood insight scale in patients with schizophrenia spectrum- and bipolar disorders

Büchmann

Pedersen

Aminoff

et al. 2019

Psychiatry Research

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The aim of this study is to investigate the validity of the Norwegian version of the Insight Scale (IS) in large and representative samples of patients with schizophrenia spectrum disorders, bipolar I disorder and bipolar II disorder. A total of 997 participants were included (schizophrenia spectrum disorders: 557; bipolar I disorder: 282; bipolar II disorder: 138). Confirmatory factor analysis was conducted to investigate the construct validity and bivariate correlational analysis was applied to investigate convergent validity. Confirmatory factor analyses indicated a reasonable model fit to the original three-factor subscale structure of the IS in all three diagnostic groups. The IS total score and its subscales correlated significantly with both the insight items in the Young Mania Rating Scale and the Positive and Negative Syndrome Scale in both schizophrenia spectrum disorders and bipolar I disorder. In the bipolar II disorder group, however, the IS subscales correlated poorly with both the observerrated measures. Our study supports the construct validity of the IS in both schizophrenia spectrum disorder-and bipolar disorder populations. The study also demonstrates that patients' self-reports of insight correspond to observer-based single item ratings of insight in bipolar I disorder and schizophrenia spectrum disorders.

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Formal thought disorder in schizophrenia and bipolar disorder: A systematic review and meta-analysis

Cited by 59 publications

References 73 publications

Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls

Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls

Disorganisation, thought disorder and socio-cognitive functioning in schizophrenia spectrum disorders

Validity of the Birchwood insight scale in patients with schizophrenia spectrum- and bipolar disorders

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