This study explores the impact of reskilling and upskilling initiatives on human resources (HR) performance to enhance HR excellence within organizations. It also investigates the mediating role of organizational support in influencing the effectiveness of HR professionals. Using a quantitative research approach, data were collected from 132 HR professionals across various industries in Nepal. This study highlights a diverse workforce in terms of gender, age, positions, and sectors of employment, emphasizing the importance of inclusivity and recognition of non-binary identities in discussions of gender diversity. The study was conducted using a descriptive and correlational research design. SPSS and SMART PLS were used for data analysis. The findings underscored the crucial role of organizational support in mediating the relationship between skill development initiatives and HR excellence, emphasizing the importance of support for HR and skill development programs. This research contributes valuable insights to the field and offers practical recommendations for enhancing the effectiveness of HR professionals. The results highlight the pivotal role of organizational support in mediating skill development impact on HR excellence. These insights offer practical recommendations for enhancing HR professionals" effectiveness and promoting inclusive HR practices.