Form und Bau der Gelenkknorpel in ihren Beziehungen zur Funktion

Benninghoff, A.

doi:10.1007/bf00583443

Cited by 422 publications

(91 citation statements)

References 7 publications

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“…However, a high/low/high intensity pattern was also observed (23). These results were interpreted as an MRI visualization of the classic 'three-zone model': a superficial tangential zone where the collagen fibers are arranged mostly parallel to the surface (however, randomly in plane), a transitional (intermediate) zone with a more isotropic fraction, and a deep zone of radial fiber orientation (17,24). In the case of Drastic changes of the MR visualized cartilage structuring can be observed for the femoral condyle.…”

Section: Age-dependence Of Collageneous Networkmentioning

confidence: 62%

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MRI assessment of cartilage ultrastructure

Gründer¹

2006

NMR in Biomedicine

121

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In T 2 -weighted MRI images joint cartilage can appear laminated. The multilaminar appearance is visualized as zones of different intensity. This appearance is based on the dipolar interaction of water molecules within cartilage zones of different collageneous network structures. Therefore, the MR visualization of zones of anisotropic arrangement of the collagen fibers depends upon their orientation to the static magnetic field (magic-angle effect). The aim of this article is to demonstrate the potential of high-resolution MRI for characterizing cartilage network structuring and biomechanical properties. Information equivalent to that from polarization light microscopy can be derived noninvasively. Based on NMR microscopic (mMRI) data, potential new possibilities of MRI for quantitative assessment of collagen structuring and intracartilagenous load distribution are presented. These methods use MR intensity angle dependence and load influence on cartilage visualization. Alternatively to the determination of mechanical parameters from cartilage deformation, it is demonstrated that stress distribution and biomechanical properties can be derived in principle from the local intensity variation of anisotropic fiber orientation zones. The limitations with respect to a clinical application of the proposed methods are discussed.

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Section: Age-dependence Of Collageneous Networkmentioning

confidence: 62%

“…1(c)] from this data. It is obvious that in this case of a juvenile animal only the MRI and PLM data for the tibial cartilage can by interpreted by the well known arcade model (17) (Fig. 2).…”

Section: Verification Of Collageneous Network Structuringmentioning

confidence: 93%

MRI assessment of cartilage ultrastructure

Gründer¹

2006

NMR in Biomedicine

121

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“…The retardance patterns measure primarily a combination of collagen densities and collagen fibril anisotropy [23,32] and the collagen density results (figure 6) show that the retardance valley reflects a decrease in collagen fibril anisotropy, and not a decrease in collagen density, in the adult animals. A decrease in collagen fibril anisotropy is the traditional interpretation of decreased retardance near the articular surface [4,6,45,46]. Our current results suggest that interpretation of retardance valleys near the articular surface in immature AC is less straightforward: the retardance valley in perinatal animals also reflects a decrease in collagen density (figure 6).…”

Section: Discussionmentioning

confidence: 53%

“…Healthy adult AC is characterised by a depth-dependent composition [1-3] and structure [4-7]. These characteristics result in depth-dependent mechanical properties [8-11] that are important for the functions of adult AC, specifically load distribution and the establishment of a low friction environment [11-13].…”

Section: Introductionmentioning

confidence: 99%

Postnatal development of depth-dependent collagen density in ovine articular cartilage

et al. 2010

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BackgroundArticular cartilage (AC) is the layer of tissue that covers the articulating ends of the bones in diarthrodial joints. Adult AC is characterised by a depth-dependent composition and structure of the extracellular matrix that results in depth-dependent mechanical properties, important for the functions of adult AC. Collagen is the most abundant solid component and it affects the mechanical behaviour of AC. The current objective is to quantify the postnatal development of depth-dependent collagen density in sheep (Ovis aries) AC between birth and maturity. We use Fourier transform infra-red micro-spectroscopy to investigate collagen density in 48 sheep divided over ten sample points between birth (stillborn) and maturity (72 weeks). In each animal, we investigate six anatomical sites (caudal, distal and rostral locations at the medial and lateral side of the joint) in the distal metacarpus of a fore leg and a hind leg.ResultsCollagen density increases from birth to maturity up to our last sample point (72 weeks). Collagen density increases at the articular surface from 0.23 g/ml ± 0.06 g/ml (mean ± s.d., n = 48) at 0 weeks to 0.51 g/ml ± 0.10 g/ml (n = 46) at 72 weeks. Maximum collagen density in the deeper cartilage increases from 0.39 g/ml ± 0.08 g/ml (n = 48) at 0 weeks to 0.91 g/ml ± 0.13 g/ml (n = 46) at 72 weeks. Most collagen density profiles at 0 weeks (85%) show a valley, indicating a minimum, in collagen density near the articular surface. At 72 weeks, only 17% of the collagen density profiles show a valley in collagen density near the articular surface. The fraction of profiles with this valley stabilises at 36 weeks.ConclusionsCollagen density in articular cartilage increases in postnatal life with depth-dependent variation, and does not stabilize up to 72 weeks, the last sample point in our study. We find strong evidence for a valley in collagen densities near the articular surface that is present in the youngest animals, but that has disappeared in the oldest animals. We discuss that the retardance valley (as seen with polarised light microscopy) in perinatal animals reflects a decrease in collagen density, as well as a decrease in collagen fibril anisotropy.

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“…The superficial zone starts from cartilage surface and it covers 20 % of cartilage thickness approximately. Collagen fibers are parallel to surface in this zone and they are randomly oriented and distributed in the surface plane [6]. The transition zone is in the middle of cartilage thickness.…”

Section: Introductionmentioning

confidence: 98%