2022
DOI: 10.3390/ani12030313
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Form of Supplemental Selenium Affects the Expression of mRNA Transcripts Encoding Selenoproteins, and Proteins Regulating Cholesterol Uptake, in the Corpus Luteum of Grazing Beef Cows

Abstract: Selenium (Se)-deficient soils necessitate supplementation of this mineral to the diet of forage-grazing cattle. Functionally, Se is incorporated into selenoproteins, some of which function as important antioxidants. We have previously shown that the source of supplemental Se; inorganic (sodium selenite or sodium selenate; ISe), organic (selenomethionine or selenocysteine; OSe) or 1:1 mix of ISe and OSe (MIX), provided to Angus-cross cows affects concentrations of progesterone (P4) during the early luteal phase… Show more

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Cited by 8 publications
(2 citation statements)
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“…Consequently, we accept the hypothesis that the pituitary and hepatic selenoprotein mRNA content of steers raised on MIX versus ISe forms of supplemental Se, and consumed MIX versus ISe forms of s u p p l e m e n t a l S e , wh i l e u n d e r go i n g s u m m e r -l o n g consumption of toxic endophyte-infected tall fescue, differed. When these findings are considered with our recent report that the mRNA content of GPX6, selenoprotein P, selenoR, and selenoV is increased in the corpus luteum (another high metabolic activity tissue) of MIX versus ISe replacement beef heifers (Carr et al, 2022), it seems reasonable to conclude that supplementation of cattle with different forms of Se affects the expressed selenoprotein transcriptome.…”
Section: Complement and Abundance Of Selenoprotein Mrna Expressed By ...mentioning
confidence: 67%
“…Consequently, we accept the hypothesis that the pituitary and hepatic selenoprotein mRNA content of steers raised on MIX versus ISe forms of supplemental Se, and consumed MIX versus ISe forms of s u p p l e m e n t a l S e , wh i l e u n d e r go i n g s u m m e r -l o n g consumption of toxic endophyte-infected tall fescue, differed. When these findings are considered with our recent report that the mRNA content of GPX6, selenoprotein P, selenoR, and selenoV is increased in the corpus luteum (another high metabolic activity tissue) of MIX versus ISe replacement beef heifers (Carr et al, 2022), it seems reasonable to conclude that supplementation of cattle with different forms of Se affects the expressed selenoprotein transcriptome.…”
Section: Complement and Abundance Of Selenoprotein Mrna Expressed By ...mentioning
confidence: 67%
“…Selenium supplementation was also found to affect progesterone levels of cows and sheep across different phases of estrus [ 284 , 285 ] and gestation [ 286 , 287 ]. Further investigation into relevant mRNA transcript levels in the corpus luteum uncovered no change in transcripts involved in progesterone synthesis, but yielded an increase in transcripts ( Ldlr and Hsl ) involved in the regulation of cholesterol availability [ 288 ]. This might suggest that selenium-induced effects on progesterone production in the corpus luteum are consequences of changes in cholesterol availability, rather than directly influencing progesterone synthesis.…”
Section: Signals From Brain To Bodymentioning
confidence: 99%