Forkhead box transcription factors in embryonic heart development and congenital heart disease

Zhu, Hong

doi:10.1016/j.lfs.2015.12.001

Cited by 76 publications

(59 citation statements)

References 80 publications

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“…Their roles include, but are not limited to, the regulation of gastrulation (Ang and Rossant, 1994;Weinstein et al, 1994), stem cell and stem cell niche maintenance (Sackett et al, 2009;Aoki et al, 2016), the regulation of metabolism and cell cycle control (Hannenhalli and Kaestner, 2009). Indeed, Fox transcription factors are required for the normal specification, differentiation, maintenance and/or function of tissues such as the trophectoderm, liver, pancreas, ovaries, intestine, lung, kidney, prostate, brain, thyroid, skeletal and heart muscle, skeleton, vascular tissue and immune cells (Zhu, 2016).…”

Section: Introductionmentioning

confidence: 99%

Fox transcription factors: from development to disease

2016

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Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human disease and, as such, various animal models have been generated to study the function of these transcription factors in mechanistic detail. In many cases, the absence of even a single Fox transcription factor is lethal. In this Primer, we provide an overview of the Fox family, highlighting several key Fox transcription factor families that are important for mammalian development.

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Section: Introductionmentioning

confidence: 99%

Fox transcription factors: from development to disease

2016

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“…Deregulating the subcellular localization, functions and expression of Forkhead box (FOX) transcription factors that are critically involved in embryonic development and multiple biological processes is known to result in the development and progression of diseases, in particular cancer [15–18]. Human FOXF transcription factors, including FOXF1 and FOXF2, are a subfamily of the FOX gene family [19].…”

Section: Introductionmentioning

confidence: 99%

The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression

Lee

Liang

et al. 2016

Cellular Signalling

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Dysregulation of Forkhead-box (FOX) transcription factors is linked to cancers of numerous tissue types. Here, we report that FOXF2 is frequently silenced in luminal-type and HER2-positive breast cancers, but is overexpressed in basal-like breast cancers; thus, FOXF2 appears to play distinct roles in different breast cancer subtypes. Inactivation of FOXF2 in luminal-type and HER2-positive breast cancers is attributable to epigenetic silencing. Silencing of FOXF2 is associated with poor prognosis in luminal-type breast cancer. Ectopic expression of FOXF2 in luminal and HER2-positive breast cancer cells suppresses their tumorigenic properties in vitro and in vivo via inhibition of the CDK2-RB-E2F cascade. The in vivo function of FOXF2 is to maintain the stringency of DNA replication, and its loss triggers dysregulation of DNA replication, which in turn activates the p53 checkpoint pathway. Besides its role in cell cycle regulation, FOXF2 is functionally required for mobility and epithelial-to-mesenchymal transition (EMT) of normal breast epithelial cells. In basal-like breast cancer cells, the cell-cycle function of FOXF2 is impaired. However, the EMT function of FOXF2 is still required for mobility, invasiveness and anchorage-independent growth of basal-like breast cancer cells. Our gene expression profiling studies demonstrate that FOXF2 regulates the expression of genes implicated in cell cycle and EMT regulation. Moreover, FOXF2 is highly co-expressed with basal- and metastasis-related genes in breast cancer. These findings suggest that FOXF2 has a dual role in breast tumorigenesis and functions as either a tumor suppressor or an oncogene depending on the breast tumor subtype.

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“…[1, 2]. More than fifty five or fifty forkhead proteins have been identified in mammals or humans genome, respectively, and they are further classified into 19 subgroups (FOXA to FOXS) basing on sequence homology inside and outside the forkhead domain [3, 4].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Zhang

Chen

et al. 2016

Oncotarget

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Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment.

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Forkhead box transcription factors in embryonic heart development and congenital heart disease

Cited by 76 publications

References 80 publications

Fox transcription factors: from development to disease

Fox transcription factors: from development to disease

The dual role of FOXF2 in regulation of DNA replication and the epithelial-mesenchymal transition in breast cancer progression

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

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