Forever Young?

Feng, Ning; Hoover, Donald B.; Paolocci, Nazareno

doi:10.1161/circresaha.107.155861

Cited by 4 publications

(2 citation statements)

References 26 publications

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“… 20 In that model, in spite of the NGF upregulation and sympathetic hyper-innervation, there was a decrease of noradrenalin synthesis and re-uptake suggesting functional denervation occurs due to nerve rejuvenation. 21 …”

Section: Causes Of Sudmentioning

confidence: 99%

Sudden death: Neurogenic causes, prediction and prevention

Japundžić‐Žigon

Šarenac

Lozić

et al. 2017

Eur J Prev Cardiolog

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Sudden death is a major health problem all over the world. The most common causes of sudden death are cardiac but there are also other causes such as neurological conditions (stroke, epileptic attacks and brain trauma), drugs, catecholamine toxicity, etc. A common feature of all these diverse pathologies underlying sudden death is the imbalance of the autonomic nervous system control of the cardiovascular system. This paper reviews different pathologies underlying sudden death with emphasis on the autonomic nervous system contribution, possibilities of early diagnosis and prognosis of sudden death using various clinical markers including autonomic markers (heart rate variability and baroreflex sensitivity), present possibilities of management and promising prevention by electrical neuromodulation.

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Section: Causes Of Sudmentioning

confidence: 99%

Sudden death: Neurogenic causes, prediction and prevention

Japundžić‐Žigon

Šarenac

Lozić

et al. 2017

Eur J Prev Cardiolog

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“…However, the role of PTEN in PH, particularly with respect to pulmonary arterial SMC proliferation, survival-signaling pathways, and the mechanisms involved remain unclear. It is possible that PTEN expression is directly downregulated by factors promoting the development of PH, including hypoxia [7, 17], or could be due to other factors associated with the remodeling process [18, 19]. …”

Section: Introductionmentioning

confidence: 99%

Dysregulation of PTEN in Cardiopulmonary Vascular Remodeling Induced by Pulmonary Hypertension

Ravi

Selvendiran

Meduru

et al. 2011

Cell Biochem Biophys

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Pulmonary hypertension (PH) is a disorder of lung vasculature characterized by arterial narrowing. Phosphatase-and-tensin homolog on chromosome 10 (PTEN), associated in the progression of multiple cancers, is implicated in arterial remodeling. However, the involvement of PTEN in PH remains unclear. The objective of the present study was to determine the role of PTEN in pulmonary vascular remodeling using established models of PH. The study used rat models of PH, induced by monocrotaline (MCT) administration (60 mg/kg) or continuous hypoxic exposure (10% oxygen) for 3 weeks. Pulmonary artery smooth muscle cells (SMCs) were used for in vitro confirmation. Development of PH was verified by hemodynamic, morphological and histopathology analyses. PTEN and key downstream proteins in pulmonary and cardiac tissues were analyzed by western blotting and RT-PCR. PTEN was significantly decreased (MCT, 53%; Hypoxia, 40%), pAkt was significantly increased (MCT, 42%; Hypoxia, 55%) in tissues of rats with PH. Similar results were observed in SMCs exposed to hypoxia (1% oxygen) for 48 h. Ubiquitination assay showed that PTEN degradation occurs via proteasomal degradation pathway. Western blotting demonstrated a significant downregulation of cell-cycle regulatory proteins p53 and p27, and upregulation of cyclin-D1 in the lungs of both models. The results showed that PTEN-mediated modulation of PI3K pathway was independent of the focal adhesion kinase and fatty acid synthase. The study, for the first time, established that PTEN plays a key role in the progression of pulmonary hypertension. The findings may have potential for the treatment of pulmonary hypertension using PTEN as a target.

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Intranasal Administration of Nerve Growth Factor Produces Antidepressant-Like Effects in Animals

Shi

Wang²,

Wu³

et al. 2010

Neurochem Res

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Many works showed that nerve growth factor (NGF) injected into the brain of animal model emerges potential antidepressant effects. However, this route of administration significantly restricts the application of NGF clinically. Here, we reported that intranasal NGF could provide an alternative to intraventricular injection. The behavioral analysis showed that intranasal administration of NGF reduced the immobility time in forced swimming test (FST) and tail suspension test (TST) in mice. Likewise, intranasal NGF increased the sucrose intake and the locomotor activity in rats after unpredictable chronic mild stress (UCMS). Furthermore, intranasal NGF increased the levels of monoamine neurotransmitters (norepinephrine, dopamine) in the frontal cortex and hippocampus and affected the number of 5-bromodeoxyuridine (BrdU), c-fos and caspase-3 positive neurons in dentate gyrus of hippocampus in rats after UCMS. In summary, intranasal NGF had significant antidepressant effects on animal models of depression and this route of administration may provide a promising way to deliver NGF to brain in a therapeutic perspective.

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Forever Young?

Cited by 4 publications

References 26 publications

Sudden death: Neurogenic causes, prediction and prevention

Sudden death: Neurogenic causes, prediction and prevention

Dysregulation of PTEN in Cardiopulmonary Vascular Remodeling Induced by Pulmonary Hypertension

Intranasal Administration of Nerve Growth Factor Produces Antidepressant-Like Effects in Animals

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