Forensic evaluation of Y-STR haplotype matches: a comment

Krawczak, Michael

doi:10.1016/s0379-0738(00)00479-5

Cited by 35 publications

(16 citation statements)

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“…Since the haplotype in question is not included in the estimation process, it does not even have to be present in the database itself. In terms of match probabilities, correctly taking the suspect haplotype into account [31], the results obtained with either the counting or the surveying method are in strong agreement for frequent haplotypes ([0.1% in a reference population). For rare haplotypes, the discrepancies are slightly more pronounced since the size of the database represents a lower limit to the prior frequency estimates that can be obtained via the counting method.…”

Section: Interpretation Of Y-chromosomal Str Profiling Resultsmentioning

confidence: 81%

“…For the frequency of a haplotype in question, the surveying method yields a ß-type posterior distribution, the mean of which is a robust estimator of the haplotype frequency [30,31]. This posterior distribution is obtained by extrapolation from the structure and frequency of all other haplotypes in the database.…”

Section: Interpretation Of Y-chromosomal Str Profiling Resultsmentioning

confidence: 99%

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Y chromosome STR typing in crime casework

Roewer

2009

Forensic Sci Med Pathol

173

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Since the beginning of the nineties the field of forensic Y chromosome analysis has been successfully developed to become commonplace in laboratories working in crime casework all over the world. The ability to identify male-specific DNA renders highly variable Y-chromosomal polymorphisms, the STR sequences, an invaluable addition to the standard panel of autosomal loci used in forensic genetics. The male-specificity makes the Y chromosome especially useful in cases of male/female cell admixture, namely in sexual assault cases. On the other hand, the haploidy and patrilineal inheritance complicates the interpretation of a Y-STR match, because male relatives share for several generations an identical Y-STR profile. Since paternal relatives tend to live in the geographic and cultural territory of their ancestors, the Y chromosome analysis has a potential to make inferences on the population of origin of a given DNA profile. This review addresses the fields of application of Y chromosome haplotyping, the interpretation of results, databasing efforts and population genetics aspects.

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Section: Interpretation Of Y-chromosomal Str Profiling Resultsmentioning

confidence: 81%

Section: Interpretation Of Y-chromosomal Str Profiling Resultsmentioning

confidence: 99%

Y chromosome STR typing in crime casework

Roewer

2009

Forensic Sci Med Pathol

173

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“…STR lokuslarının polimeraz zincir reaksiyonu [polymerase chain reaction (PCR)]'na dayalı analizi ile karşılaştırıldığında, aynı seviyede ayrım gücüne ulaşılabilmesi için yaklaşık 50-80 biallelik SNP kullanılması gerektiği belirtilmiştir. 11,12 Bununla birlikte, genom içinde çok sayıda SNP'nin aynı anda analizi ile SNP için Turkiye Klinikleri J Foren Med 2016;13 (2) 48 ŞEKİL 1: Farklı mutasyon tipleri ile oluşan tek nükleotid polimorfizmin yapısı. dezavantaj olarak sunulan sınırlı bilginin telafi edilebileceği de öngörülmektedir.…”

Section: İdentifikasyona Dayalı Adli Uygulamalardaunclassified

Single Nucleotide Polymorphisms in Forensic Applications Based on Identification: Review

Serin¹,

Canan²,

Ulubay³

2016

Turkiye Klinikleri J Foren Med

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“…usually 0.05 [38, 39] 4 The "surveying" methods [40,41] 5 p ¼ x n þ q 1 À x n À Á [15,16], where θ is the measure of population substructure 6 Upper bound of 95% binomial confidence interval [16];…”

Section: Haplotype Frequencymentioning

confidence: 99%

Pedigree likelihood ratio for lineage markers

Eisenberg

Yan

et al. 2010

Int J Legal Med

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Lineage-based haplotype markers (e.g., Y chromosome STRs and mitochondrial DNA sequences) are important adjunct tools to the autosomal markers for kinship analysis and for specialized kinship applications such as database searching. Traditionally, the prosecution or kinship hypothesis considers the haplotypes in the same lineage and the probability of genotype data given the lineage hypothesis is simply set at 1 if the number of mismatched loci or nucleotides between the questioned person and the references is less than a predefined threshold. In this study, a kinship hypothesis based on a fixed relationship of the questioned person in the reference family is introduced. A graphical model is proposed to calculate the probability of the genotype data given the kinship hypothesis, which is the product of haplotype frequency of the founder in the pedigree and the transmission probability from the founder to all descendants. Proper mutation models are suggested for Y chromosome STRs and mitochondrial DNA sequence variants (i.e., SNPs) to calculate the transmission probability. The methods to infer the genotypes of the untyped individuals in the pedigree and the computational complexity of handling these untyped individuals are also addressed. Lastly, numerical examples of the applications are given to demonstrate the kinship hypothesis and the algorithms.

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Forensic evaluation of Y-STR haplotype matches: a comment

Cited by 35 publications

References 1 publication

Y chromosome STR typing in crime casework

Y chromosome STR typing in crime casework

Single Nucleotide Polymorphisms in Forensic Applications Based on Identification: Review

Pedigree likelihood ratio for lineage markers

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