Forensic analysis of eleven cyclic antidepressants in human biological samples using a new reversed-phase chromatographic column of 2 μm porous microspherical silica gel

Tanaka, Einosuke; Terada, Masaru; Nakamura, Takako; Misawa, Shogo; Wakasugi, Choei

doi:10.1016/s0378-4347(96)00510-5

Cited by 50 publications

(24 citation statements)

References 18 publications

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“…Although the separation of antidepressants in biological sample matrix by LC has been reported, [30][31][32] conventional LLE techniques are still mainly employed routinely in the sample pretreatment procedure.…”

Section: Wire-in-tube Spme/lcmentioning

confidence: 99%

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

et al. 2002

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Miniaturized extraction and separation media have been successfully developed from precisely controlled technologies. In this article, recent developments in these high performance analytical methods, such as miniaturized sample preparation methods and the coupling of these techniques with microscale separation systems, have been reviewed, along with some applications to environmental and biological analysis. The advantage of the miniaturization is not only for the environmental compatibility but also for the developments of the high performance analytical systems. Down-sizing also makes it possible to investigate and introduce various compounds and materials as novel media (such as tailor-made materials and devices) in separation science. As a typical example of the novel miniaturized sample preparation system, the applications of fibrous materials for microcolumn liquid-phase separation methods are described.

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Section: Wire-in-tube Spme/lcmentioning

confidence: 99%

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

et al. 2002

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“…[11][12][13][14] Meanwhile, the abuse of ATDs has become a significant problem in societies across the world because of their easy availability and toxicological effect. [15][16][17][18][19] Over the past decades, forensic cases related to ATDs abuse was quite common, such as driving under the influence of drugs, violent crime, drug-facilitated sexual assault and other cases of sudden or violent deaths. [20][21][22] Therefore, ATDs and/or PETs are some of the most frequently encountered compounds in forensic and clinical cases.…”

Section: Introductionmentioning

confidence: 99%

Determination of 13 Organic Toxicants in Human Blood by Liquid-Liquid Extraction Coupling High-Performance Liquid Chromatography Tandem Mass Spectrometry

Song

2016

ANAL. SCI.

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Pesticides and antidepressants are frequently misused in drug-facilitated crime because of their toxicological effect and easy-availability. Therefore, it is essential for the development of a simple and reliable method for the determination of these organic toxicants in biological fluids. Here, we report on an applicable method by the combination of optimized liquid-liquid extraction (LLE) procedure and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to identify and quantify dimethoate, omethoate, dichlorvos, carbofuran, fenpropathrin, diazepam, estazolam, alprazolam, triazolamm, chlorpromazine, phenergan, barbitone and phenobarbital in human blood. The method demonstrated a linear calibration curve in range of 20 -500 μg/L (r > 0.994). The accuracy evaluated by recovery spiked at three different concentrations (50, 100 and 200 μg/L) was in the range of 58.8 -83.1% with a relative standard deviations (RSD) of 3.7 -7.4%. The limits of quantification ranged over 6.7 -33.3 μg/L. This method was proved to be simple and reliable, and was thus successfully applied to forensic toxicology.

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“…The simultaneous determination of antidepressants has so far been carried out by GC [1][2][3][4][5][6] and HPLC. [7][8][9][10][11] However, the simultaneous determination of all antidepressants by these methods is very difficult in a single run because of similar properties and structures.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Antidepressants by Non-aqueous or Quasi-non-aqueous Capillary Electrophoresis

et al. 2010

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Forensic analysis of eleven cyclic antidepressants in human biological samples using a new reversed-phase chromatographic column of 2 μm porous microspherical silica gel

Cited by 50 publications

References 18 publications

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

Miniaturized Sample Preparation and Separation Methods for Environmental and Drug Analyses

Determination of 13 Organic Toxicants in Human Blood by Liquid-Liquid Extraction Coupling High-Performance Liquid Chromatography Tandem Mass Spectrometry

Simultaneous Determination of Antidepressants by Non-aqueous or Quasi-non-aqueous Capillary Electrophoresis

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