Forebrain structures regulating flight behavior in the cat

Shaikh, Majid B.; Brutus, Martin; Siegel, Heidi E.; Siegel, Allan

doi:10.1016/0361-9230(85)90085-1

Cited by 22 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CeL/CeM–BSTvl pathway could play a complementary role in anxiety, autonomic response, aversive behaviours and hypoalgesia induced by noxious stimuli. Indeed, the BSTL is clearly involved in stressfull and aversive behaviour (exploratory, escape, flight, hissing behaviours) and accompanied reactions (adrenocortical secretion and gastric pathology, Henke, 1984; Shaikh et al ., 1985, 1986; Brutus et al ., 1988; Feldman et al ., 1990; Hermann et al ., 1990; Casada & Dafny, 1991; Xu et al ., 1999). Furthermore, the BSTL (that includes the BSTvl) projects to several brainstem autonomic control nuclei, namely the PB, the NTS, the vagus dorsal motor and the ambiguous nuclei (Sofroniew, 1983; Holstege et al ., 1985; Moga et al ., 1989; see review in de Olmos et al ., 1985).…”

Section: Discussionmentioning

confidence: 99%

Projections from the nociceptive area of the central nucleus of the amygdala to the forebrain: a PHA‐L study in the rat

Bourgeais

Gauriau

Bernard

2001

Eur J of Neuroscience

135

View full text Add to dashboard Cite

The lateral capsular division (CeLC) of the central nucleus (Ce) of the amygdala, in the rat, has been shown to be the main terminal area of a spino(trigemino)-parabrachio-amygdaloid nociceptive pathway [Bernard & Besson (1990) J. Neurophysiol. 63, 473-490; Bernard et al. (1992) J. Neurophysiol. 68, 551-569; Bernard et al. (1993) J. Comp. Neurol. 329, 201-229]. The projections to the forebrain from the CeLC and adjacent regions were studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin (PHA-L) restricted in subdivisions of the Ce and the basolateral amygdaloid nucleus anterior (BLA). Our data showed that the entire CeLC projects primarily and extensively to the substantia innominata dorsalis (SId). The terminal labelling is especially dense in the caudal aspect of the SId. The other projections of the CeLC in the forebrain were dramatically less dense. They terminate in the bed nucleus of the stria terminalis (BST) and the posterior hypothalamus (pLH). No (or only scarce) other projections were found in the remaining forebrain areas. The Ce lateral division (CeL) and the Ce medial division (CeM), adjacent to the CeLC, also project to the SId with slightly lower density labelling. However, contrary to the case of the CeLC, both the CeL and the CeM extensively project to the ventrolateral subnucleus of the BST (BSTvl) with a few additional terminals found in other regions of the lateral BST. Only the CeM projects densely to both the interstitial nucleus of the posterior limb of the anterior commissure and the caudal most portion of the pLH. The projections of the BLA are totally different from those of the Ce as they terminate in the dorsal striatum, the accumbens nucleus, the olfactory tubercle, the nucleus of olfactory tract and the rostral pole of the cingulate/frontal cortex. This study demonstrates that the major output of the nociceptive spino(trigemino)-parabrachio-CeLC pathway is to the SId. It is suggested that the CeLC-SId pathway could have an important role in anxiety, aversion and genesis of fear in response to noxious stimuli.

show abstract

Section: Discussionmentioning

confidence: 99%

Projections from the nociceptive area of the central nucleus of the amygdala to the forebrain: a PHA‐L study in the rat

Bourgeais

Gauriau

Bernard

2001

Eur J of Neuroscience

135

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…For instance, stimulation of the central amygdaloid nucleus elicits increases in blood pressure and heart rate accompanied by an elevation of plasma catecholamines (Shaikh et al, 1985;Iwata et al, 1987;Brown & Gray, 1988). These effects appear to be mediated by projections of the central nucleus to the brainstem and hypothalamic nuclei involved in species-speci®c emotional behaviours and behavioural state control (Kaada, 1967(Kaada, , 1972Hopkins & Holstege, 1978;Bandler, 1982;Silvestri & Kapp, 1998).…”

Section: Implications For the Activity Of Target Structuresmentioning

confidence: 99%

Spontaneous and evoked activity of intercalated amygdala neurons

Collins

Paré

1999

Eur J of Neuroscience

View full text Add to dashboard Cite

The intercalated cell masses are clusters of GABAergic neurons interposed between the basolateral and centromedial nuclear groups of the amygdala. Tract-tracing studies have revealed that the main projection sites of intercalated neurons are the central amygdaloid nucleus and the basal forebrain. Through these projections, intercalated neurons could influence the activity of widespread regions of the central nervous system. However, no data are available regarding their physiological properties because of the paramount methodological difficulties raised by the small size of intercalated cell masses. Here, we have investigated the spontaneous and evoked activity of intercalated neurons in unanaesthetized, chronically implanted cats. Extracellular recording sites were identified using stringent histological criteria. The intercalated cell masses were found to contain a population of neurons firing at much higher rates than commonly observed in neighbouring amygdaloid nuclei. Individual intercalated neurons displayed state-dependent changes in firing rates, but these varied from cell to cell. Most tested intercalated neurons displayed short-latency orthodromic responses to cortical shocks and were responsive to a variety of auditory stimuli. Considering that the vast majority of intercalated neurons use gamma-aminobutyric acid (GABA) as a transmitter, the presence of neurons with high spontaneous firing rates within the intercalated cell masses suggests that these cell clusters may provide a tonic inhibitory input to their projection sites. Moreover, the fact that the firing probability of some intercalated neurons could be altered by the presentation of sensory stimuli suggests that this inhibitory input can be modulated as a function of environmental contingencies.

show abstract

“…Many of the agonist behavior, and reproduction) are lamp positive as well. For example, 1) the preopticohypothalamic area and its connections play a crucial role in reproductive behavior and the maintenance of the internal milieu, thereby facilitating visceromotor responses (involving cardiovascular and respiratory function), modulation of the release of pituitary hormones, and feeding and drinking behavior (Shute and Lewis, 1967;Motokizawa and Furuya, 1973;Holstege et al, 1977;Swanson, 1977;Loewy and Burton, 1978;Saper, 1982a,b;Luiten et al, 1987;Nieuwenhuys et al, 1988;Loewy, 1991); 2) the bed nucleus of the stria terminalis, subfornical organ, ventromedial hypothalamic nuclei, amygdala, subiculum, medial prefrontal cortex, paraventricular nuclei of the thalamus, medial habenulae, nucleus accumbens, substantia innominata, substantia nigra, ventral tegmental areas, central gray of the midbrain, locus coeruleus, ascending and lateral reticular systems, and cerebellum play an important role in autonomic and locomotor function that facilitate agonist behavior, as in the defensive "flight" response (Jacobs et al, 1981;Hilton et al, 1983;Shaikh et al, 1985;Swanson and Lind, 1986;Swanson, 1991;Cowie and Holstege, 1992); such defensive reactions arise as a consequence of a reflex chain initiated by sensory perception and the central relay of somesthetic information (e.g., pain, auditory, and visual) either directly to autonomic centers in the brain (Dietrichs, 1984;Burstein and Potrebic, 1993;Giesler et al, 1994) or mediated through sensory relays in the thalamus and brainstem (Borg, 1973;Pritchard et al, 1986;Kudo and Niimi, 1981;Bandler et al, 1991;Holstege, 1991;Burstein and Potrebic, 1993;Giesler et al, 1994); and 3) the hippocampus, cingulate and prefrontal cortex, amygdala, and dentate nucleus subserve cognitive functions relating to emotion, motivation, learning, and memory (Swanson and Cowan, 1977;…”

Section: Classical Limbic Structures In Tele-and Diencephalic Areas Smentioning

confidence: 98%

Expression of the mRNAs encoding the limbic system‐associated membrane protein (LAMP): I. Adult rat brain

1996

View full text Add to dashboard Cite

The search for molecular markers common to neural structures that are functionally related has become an attractive strategy for neurobiologists interested in identifying mechanisms involved in the formation of patterned connections. One such molecule is the limbic system-associated membrane protein (LAMP), a 64-68 kDa glycoprotein that is expressed in the soma and dendrites of subpopulations of adult neurons in the brain that are functionally associated with classic limbic structures. Such patterned molecular specificity is established prenatally; LAMP is detected during development on the surface of neurons, axonal membranes and pathfinding growth cones. This molecule has now been cloned (lamp) and has been shown to be highly conserved in rat and human. It is a new immunoglobulin superfamily member that has three Ig domains and a glycosyl-phosphatidylinositol (GPI) anchor to the cell membrane. In this study, the distribution of the lamp transcript in the adult rat brain was determined by using in situ hybridization. Generally, the distribution of lamp corresponds well with that of the LAMP protein. Within the cerebral cortex, the transcript is more abundant in areas that are associated with learning/memory and viscerosensory tasks. It is less abundant in somatic sensory and motor areas. The lamp transcript is also ubiquitous in the basal forebrain, amygdala, and preopticohypothalamic areas. In short, the lamp transcript is expressed heavily in areas of the forebrain and diencephalon that have been classically considered limbic and sparsely or moderately in nonlimbic midbrain and hindbrain regions. Correlative analysis of the connectivity patterns of the regions that express greater amounts of the transcript is consistent with a stronger limbic-associated function relative to the regions expressing less lamp. These quantitative differences may be significant in determining the function of LAMP in the adult brain.

show abstract

Forebrain structures regulating flight behavior in the cat

Cited by 22 publications

References 23 publications

Projections from the nociceptive area of the central nucleus of the amygdala to the forebrain: a PHA‐L study in the rat

Projections from the nociceptive area of the central nucleus of the amygdala to the forebrain: a PHA‐L study in the rat

Spontaneous and evoked activity of intercalated amygdala neurons

Expression of the mRNAs encoding the limbic system‐associated membrane protein (LAMP): I. Adult rat brain

Contact Info

Product

Resources

About