Forearm haemodynamics, arterial stiffness and microcirculatory reactivity in rheumatoid arthritis

Arosio, Enrico; Marchi, Sergio De; Rigoni, Annamaria; Prior, Manlio; Delva, Pietro; Lechi, Alessandro

doi:10.1097/hjh.0b013e3280b0157e

Cited by 86 publications

(67 citation statements)

References 21 publications

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“…It is known that chronic inflammation (32) and endothelial dysfunction, which is characterized by a reduction in the bioavailability of NO as a result of an NO synthase blockade that seems to be the first cause of the atherosclerotic process, are important factors in the development of atherosclerotic plaque (33). ADMA is the main endogenous inhibitor of all 3 NO synthases, which suggests that ADMA is involved in endothelial dysfunction and atherosclerosis (34).…”

Section: Significance and Innovationsmentioning

confidence: 99%

Silent cardiovascular involvement in patients with diffuse systemic sclerosis: a controlled cross‐sectional study

Turiel¹,

Gianturco²,

Ricci³

et al. 2013

Arthritis Care & Research

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Objective. An association between systemic autoimmune diseases and atherosclerosis has been described in many connective tissue diseases, and this association is known to lead to increased cardiovascular morbidity and mortality. Systemic sclerosis (SSc) is characterized by multisystem organ inflammation, endothelial wall damage, and vasculopathy. There are many markers of endothelial dysfunction and/or atherosclerotic risk, such as asymmetric dimethylarginine (ADMA), arterial stiffness parameters, carotid intima-media thickness (CIMT), and coronary flow reserve (CFR) assessed by transthoracic echocardiography. The aim of this pilot study was to use various endothelial and atherosclerosis markers to identify early cardiovascular involvement in a group of SSc patients. Methods. The study involved 20 patients (2 men and 18 women with a mean ؎ SD age of 52.96 ؎ 12.51 years) with diffuse SSc who had no signs or symptoms of cardiovascular disease (CVD) and 20 age-and sex-matched controls. All subjects underwent a dipyridamole echocardiographic stress test that included a determination of CFR and an evaluation of CIMT, arterial stiffness, and plasma ADMA levels. Results. All of the arterial wall measurements of the patients with diffuse SSc were significantly different from those of the controls, and both right and left CIMT, pulse wave velocity, and stiffness index (␤) were significantly elevated in the SSc patients compared to the healthy controls. Moreover, in patients with diffuse SSc, CFR was significantly lower (P ‫؍‬ 0.0033) and plasma ADMA levels were higher (P < 0.0001) than in healthy controls. Conclusion. SSc patients without any clinical evidence of CVD seem to have had subclinical atherosclerosis, which was suggested by early impairment of coronary microcirculation and macrovascular involvement.

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Section: Significance and Innovationsmentioning

confidence: 99%

Silent cardiovascular involvement in patients with diffuse systemic sclerosis: a controlled cross‐sectional study

Turiel¹,

Gianturco²,

Ricci³

et al. 2013

Arthritis Care & Research

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“…10 -11 Most, but not all, demonstrate abnormal endothelial function, arterial stiffness, and carotid intima-media thickness (IMT) in RA patients compared to healthy controls. [12][13][14] Some of these abnormalities may be reversible. 15 Very few, if any, studies have addressed the degree to which classical CVD risk factors and systemic inflammation each contribute to vascular abnormalities in RA.…”

mentioning

confidence: 99%

Atherosclerosis in Rheumatoid Arthritis Versus Diabetes

Stamatelopoulos

Kitas

Papamichael

et al. 2009

ATVB

173

114

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Objective-The extent to which atherosclerosis is accelerated in chronic inflammatory diseases is not established. We compared preclinical atherosclerosis in rheumatoid arthritis with diabetes mellitus, a known coronary heart disease equivalent. Methods and Results-Endothelial function, arterial stiffness, carotid intima-media thickness, and analysis of atheromatous plaques were examined in 84 rheumatoid arthritis patients without cardiovascular disease versus healthy controls matched for age, sex, and traditional cardiovascular disease risk factors, as well as in 48 diabetes patients matched for age, sex, and disease duration with 48 rheumatoid arthritis patients. Rheumatoid arthritis duration associated with arterial stiffening, whereas disease activity associated with carotid plaque vulnerability. All markers of preclinical atherosclerosis were significantly worse in rheumatoid arthritis compared to controls, whereas they did not differ in comparison to diabetes despite a worse cardiovascular risk factor profile in diabetics. Both diseases were associated independently with increased intima-media thickness; rheumatoid arthritis, but not diabetes, was independently associated with endothelial dysfunction. Conclusions-Preclinical

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“…Additional cardiovascular risk factors were not mentioned. Arosio et al [26] measured brachio-radial PWV (a muscular segment of the arterial tree) with an alternative method (piezoelectric plethysmography) in RA patients without traditional cardiovascular risk factors and found it to be increased as compared to controls. All these results are in line with our data.…”

Section: Discussionmentioning

confidence: 99%

Arterial stiffness in a muscular artery in women with longstanding rheumatoid arthritis compared with healthy controls and patients with traditional cardiovascular risk factors

et al. 2009

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Forearm haemodynamics, arterial stiffness and microcirculatory reactivity in rheumatoid arthritis

Abstract: Female rheumatoid arthritis patients present with impaired microcirculatory reactivity, endothelial dysfunction and increased arterial stiffness. Alterations in the vascular bed are extended and may explain the increased incidence of cardiovascular events in these patients.

Cited by 86 publications

References 21 publications

Silent cardiovascular involvement in patients with diffuse systemic sclerosis: a controlled cross‐sectional study

Silent cardiovascular involvement in patients with diffuse systemic sclerosis: a controlled cross‐sectional study

Atherosclerosis in Rheumatoid Arthritis Versus Diabetes

Arterial stiffness in a muscular artery in women with longstanding rheumatoid arthritis compared with healthy controls and patients with traditional cardiovascular risk factors

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