Atherosclerosis in Rheumatoid Arthritis Versus Diabetes

Stamatelopoulos, Kimon; Kitas, George D.; Papamichael, Christos; Chryssohoou, Elda; Kyrkou, Katerina; Georgiopoulos, G; Protogerou, Athanase D.; Panoulas, Vasileios F.; Sandoo, Aamer; Tentolouris, Nikolaοs; Mavrikakis, Myron; Sfikakis, Petros P.

doi:10.1161/atvbaha.109.190108

Cited by 173 publications

(133 citation statements)

References 40 publications

(45 reference statements)

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“…Endothelial dysfunction was deteriorated to a similar extent in patients with systemic and nonsystemic JIA. Impaired FMD has been consistently observed in adult patients with CID, such as rheumatoid arthritis (11,13), as well as in children with Kawasaki disease (23), a systemic vasculitis that occurs mainly in younger ages. Recently, no difference in FMD between children/adolescents with systemic lupus erythematosus and healthy controls (24,25) was reported.…”

Section: Discussionmentioning

confidence: 99%

“…These findings probably reflect differences in methods used to assess aortic PWV in various studies. Increased PWV, a marker of adverse cardiovascular prognosis in various adult populations (5), has been demonstrated in adult CID patients (11,32) and children at high cardiovascular risk (7,33). LAEI and SAEI are relatively novel markers of arterial compliance that have been associated with cardiovascular risk factors (34,35) and CID in adults (36), but their value in cardiovascular prognosis is not known.…”

Section: Discussionmentioning

confidence: 99%

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Changes in vascular function and structure in juvenile idiopathic arthritis

Vlahos¹,

Theocharis²,

Bechlioulis³

et al. 2011

Arthritis Care & Research

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Objective. Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health. Methods. Thirty patients with JIA (age range 7-18 years) were compared to 33 age-and sex-matched controls. Endothelial function (brachial artery flow-mediated dilation [FMD]), carotid intima-media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM-1) and P-selectin measurements. Results. Patients with JIA showed decreased FMD compared to controls (P ‫؍‬ 0.001), independent of age (P ‫؍‬ 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM-1, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (P ‫؍‬ 0.014, P ‫؍‬ 0.069, and P ‫؍‬ 0.046, respectively). The difference in IMT between systemic versus oligoarticular/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease. Conclusion. Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease-related characteristics (inflammation, disease activity, and medications).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Changes in vascular function and structure in juvenile idiopathic arthritis

Vlahos¹,

Theocharis²,

Bechlioulis³

et al. 2011

Arthritis Care & Research

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“…In addition, patients with RA had a similar carotid IMT and prevalence of carotid plaque as with age-and gender-matched patients with type 2 diabetes mellitus. The result thus suggested that both diseases contribute equally to the development of premature atherosclerosis [18]. A meta-analysis was performed involving 22 studies to estimate the overall mean carotid IMT difference between RA and control groups [19].…”

Section: Subclinical Atherosclerosis Carotid Intima-media Thicknessmentioning

confidence: 99%

Atherosclerosis in Patients with Rheumatoid Arthritis

Zeng¹

2013

Rheumatology (Sunnyvale)

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Wu et al., Rheumatol Curr Res 2013, S5 http://dx.doi.org/10.4172/2161-1149 Review ArticleOpen Access AbstractBoth Rheumatoid Arthritis (RA) and atherosclerosis are complex polygenic diseases. Previous studies have demonstrated that patients with RA are associated with up to 60% increased risk of cardiovascular disease related death. Nonetheless, the increased cardiovascular morbidity and mortality in patients with RA cannot be entirely explained by traditional risk factors, and likely to be multifactorial. The present article reviews the data supporting the association of RA with cardiovascular risk factors, possible mechanism for developing atherosclerosis and evaluates the potential strategies that may prevent premature atherosclerosis in these patients.

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“…1 Chronic inflammation is the most important reason for accelerated atherosclerosis development in RA. 2 Cytokines involved in the systemic circulation in RA have altered function in distant organs such as adipose tissue, liver, and skeletal muscle. Thus, they cause a series of atherogenic changes such as insulin resistance, dyslipidemia, oxidative stress, thrombotic effects, endothelial dysfunction, and injury.…”

mentioning

confidence: 99%

Number of Metabolic Syndrome Risk Factors is Related to Carotid Intima-Media Thickness in Rheumatoid Arthritis Patients

et al. 2015

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Objectives:This study aims to investigate the relationship between carotid intima-media thickness (CIMT) and clinical and metabolic variables in rheumatoid arthritis (RA) patients. Patients and methods: The study included 76 RA patients (18 males, 58 females; mean age 50.1±9.8 years; range 21 to 69 years) and 42 control subjects (11 males, 31 females; mean age 49.2±9.7; range 28 to 66 years). Erythrocyte sedimentation rate, C-reactive protein, and disease activity score were used to assess disease activation. Rheumatoid factor, anti-cyclic citrullinated peptide antibodies, and metabolic syndrome components (fasting blood glucose, high density lipoprotein-cholesterol, triglyceride, blood pressure, and waist circumference) were measured. Results: Mean disease duration was 6.9±6.5 years. Patients with RA had higher CIMT than the controls (0.8±0.1 and 0.6±0.2, respectively; p<0.001). Statistically significant positive correlations were observed between CIMT and age, erythrocyte sedimentation rate, C-reactive protein, and systolic and diastolic blood pressure. The CIMT in RA patients having metabolic syndrome risk components ranging from one to four were 0.76±0.16, 0.82±0.14, 0.86±0.13, and 0.92±0.13, respectively. CIMT was positively correlated with the number of metabolic syndrome risk components. Conclusion: Our study has shown elevated CIMT in RA. Presence of metabolic syndrome components in RA patients increases tendency to atherosclerosis and constitutes a severe risk for cardiovascular disease.

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Atherosclerosis in Rheumatoid Arthritis Versus Diabetes

Cited by 173 publications

References 40 publications

Changes in vascular function and structure in juvenile idiopathic arthritis

Changes in vascular function and structure in juvenile idiopathic arthritis

Atherosclerosis in Patients with Rheumatoid Arthritis

Number of Metabolic Syndrome Risk Factors is Related to Carotid Intima-Media Thickness in Rheumatoid Arthritis Patients

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