Force platform for rats measures fore and hind forces concurrently

Welch, Jo; Wade, Jerernie A.; Hillberry, B. M.; Weaver, Connie M.

doi:10.1016/j.jbiomech.2009.08.002

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…While these same models can theoretically be applied to rodents, technologies to accurately assess 3-D kinematics in rodents are still in development ( see Considerations section). As such, current kinematic measures of rodent gait are largely related to foot and ankle orientation [41–43], and current dynamic measures of rodent gait are largely limited to ground reaction forces [17••, 44, 21, 45, 46, 22, 47]. …”

Section: Characteristics Of Rodent Gaitmentioning

confidence: 99%

Gait Analysis Methods for Rodent Models of Osteoarthritis

Jacobs

Kloefkorn

Allen

2014

Curr Pain Headache Rep

135

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Patients with osteoarthritis (OA) primarily seek treatment due to pain and disability, yet the primary endpoints for rodent OA models tend to be histological measures of joint destruction. The discrepancy between clinical and preclinical evaluations is problematic, given that radiographic evidence of OA in humans does not always correlate to the severity of patient-reported symptoms. Recent advances in behavioral analyses have provided new methods to evaluate disease sequelae in rodents. Of particular relevance to rodent OA models are methods to assess rodent gait. While obvious differences exist between quadrupedal and bipedal gait sequences, the gait abnormalities seen in humans and in rodent OA models reflect similar compensatory behaviors that protect an injured limb from loading. The purpose of this review is to describe these compensations and current methods used to assess rodent gait characteristics, while detailing important considerations for the selection of gait analysis methods in rodent OA models.

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Section: Characteristics Of Rodent Gaitmentioning

confidence: 99%

Gait Analysis Methods for Rodent Models of Osteoarthritis

Jacobs

Kloefkorn

Allen

2014

Curr Pain Headache Rep

135

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show abstract

“…Since the first force platform was invented in 1938 to measure the three-dimensional (3D) RFs of a cat moving on a horizontal substrate (Manter 1938), many researches have been conducted to measure the ground RFs (Sparrow and Tirosh 2005) or 3D RFs (Chateau et al 2009, Lin andTrimmer 2012). A 3D force platform was developed (Full and Tu 1990, 1991, Biewener and Full 1992 and has been employed to measure the 3D RFs of different animals , Goldman et al 2006, Mcelroy and Reilly 2009, Welch et al 2009. Chen et al have measured the complete RFs of geckos (Hemidactylus garnotii) under trotting gait where the duty factor less than 0.5.…”

Section: Introductionmentioning

confidence: 99%

Biomechanics of gecko locomotion: the patterns of reaction forces on inverted, vertical and horizontal substrates

Wang

Dai

et al. 2015

Bioinspir. Biomim.

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The excellent locomotion ability of geckos on various rough and/or inclined substrates has attracted scientists' attention for centuries. However, the moving ability of gecko-mimicking robots on various inclined surfaces still lags far behind that of geckos, mainly because our understanding of how geckos govern their locomotion is still very poor. To reveal the fundamental mechanism of gecko locomotion and also to facilitate the design of gecko-mimicking robots, we have measured the reaction forces (RFs) acting on each individual foot of moving geckos on inverted, vertical and horizontal substrates (i.e. ceiling, wall and floor), have associated the RFs with locomotion behaviors by using high-speed camera, and have presented the relationships of the force components with patterns of reaction forces (PRFs). Geckos generate different PRF on ceiling, wall and floor, that is, the PRF is determined by the angles between the direction of gravity and the substrate on which geckos move. On the ceiling, geckos produce reversed shear forces acting on the front and hind feet, which pull away from the body in both lateral and fore-aft directions. They use a very large supporting angle from 21° to 24° to reduce the forces acting on their legs and feet. On the floor, geckos lift their bodies using a supporting angle from 76° to 78°, which not only decreases the RFs but also improves their locomotion ability. On the wall, geckos generate a reliable self-locking attachment by using a supporting angle of 14.8°, which is only about half of the critical angle of detachment.

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Free-fall landing and interval running have different effects on trabecular bone mass and microarchitecture, serum osteocalcin, biomechanical properties, SOST expression and on osteocyte-related characteristics

Boudenot

Pallu

Uzbekov

et al. 2021

Appl. Physiol. Nutr. Metab.

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The effects of treadmill interval training (IT) and free fall exercise were evaluated on bone parameters including osteocyte related characteristics. Thirty-eight 4-month-old male Wistar rats were randomly divided into a control group (C) and exercise groups: IT, 10 free fall impacts/day with a 10s (FF10) or 20s interval between drops (FF20), 5 days/week, for 9 weeks. We assessed: BMD, microarchitecture by µCT, mechanical strength by a three-point bending test, density and occupancy of the osteocyte lacunae by toluidine blue staining, osteocalcin and NTx systemic levels by ELISA, and bone tissue Sost mRNA expression by RT-PCR. NTx levels were significantly lower in exercise groups as compared to C. In exercise groups Sost mRNA expression was significantly lower than in C. Tb.N was significantly higher for IT and FF20 compared to C; Tb.Sp was significantly lower in FF10 compared to C. Both IT and FF20 were associated with higher tibial lacunar density as compared to FF10. Compared to FF10, IT fat mass was lower, while tibial osteocyte lacunae occupancy and systemic osteocalcin level were higher. All exercise modes were efficient in reducing bone resorption. Both IT and FF impact with appropriate recovery periods might be beneficial for bone health and osteocyte related characteristics. Novelty bullets: • Interval training is beneficial for bone mineral density • Exercises decreased both bone resorption and inhibition of bone formation (sost mRNA) • Longer interval recovery time favors osteocyte lacunae density

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Force platform for rats measures fore and hind forces concurrently

Cited by 4 publications

References 25 publications

Gait Analysis Methods for Rodent Models of Osteoarthritis

Gait Analysis Methods for Rodent Models of Osteoarthritis

Biomechanics of gecko locomotion: the patterns of reaction forces on inverted, vertical and horizontal substrates

Free-fall landing and interval running have different effects on trabecular bone mass and microarchitecture, serum osteocalcin, biomechanical properties, SOST expression and on osteocyte-related characteristics

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