Force Feedback Interface for Cell Injection

Pillarisetti, Anand; Anjum, Waqas; Desai, Jaydev P.; Friedman, Gary D.; Brooks, Ari D.

doi:10.1109/whc.2005.57

Cited by 38 publications

(16 citation statements)

References 53 publications

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“…Results show that the stability of the cell punction is improved when adding haptic feedback about cellular forces and the viscosity of the medium. Similarly, Pillarisetti et al (2005) developed a haptic system capable of measuring cell injection forces and providing a suitable feedback to the user through a Phantom Premium device. All subjects were able to correctly detect the puncturing of the membrane through the haptic interface.…”

Section: Electrostatic Active Sensorsmentioning

confidence: 99%

Haptic Feedback for Microrobotics Applications: A Review

et al. 2016

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Microrobotics systems are showing promising results in several applications and scenarios, such as targeted drug delivery and screening, biopsy, environmental control, surgery, and assembly. While most of the systems presented in the literature consider autonomous techniques, there is a growing interest in human-in-the-loop approaches. For reasons of responsibility, safety, and public acceptance, it is in fact beneficial to provide a human with intuitive and effective means for directly controlling these microrobotic systems. In this respect, haptic feedback is widely believed to be a valuable tool in human-in-the-loop teleoperation systems. This article presents a review of the literature on haptic feedback systems for microrobotics, categorizing it according to the type of haptic technology employed. In particular, we considered both tethered and untethered systems, including applications of micropositioning, microassembly, minimally invasive surgery, delivery of objects, micromanipulation, and injection of cells. One of the main challenges for an effective implementation is stability control. In fact, the high scaling factors introduced to match variables in the macro and the micro worlds may introduce instabilities. Another challenge lies in the measurement of position and force signals in the remote environment. The integration of microsized sensors may significantly increase the complexity and cost of tools fabrication. To overcome the lack of force-sensing, vision seems a promising solution. Finally, although the literature on haptic feedback for untethered microrobotics is still quite small, we foreseen a great development of this field of research, thanks to its flexible applications in biomedical engineering scenarios.

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Section: Electrostatic Active Sensorsmentioning

confidence: 99%

Haptic Feedback for Microrobotics Applications: A Review

et al. 2016

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“…For example, in single cell injection, the force feedback has been applied successfully to improve the injection process (Figure 6b) [21,91]. The challenge for force sensing lies on the lack of force/torque information from different directions.…”

Section: Sensingmentioning

confidence: 99%

State of the art: micro-nanorobotic manipulation in single cell analysis

Shen

Fukuda

2014

Robot. Biomim.

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Single cell analysis is an essential research approach to reveal the secret of life. At such a small scale, it puts forward higher demand on the accuracy of the cell manipulation system. This paper reviews the state of the art of micro-nanorobotic manipulation in single cell analysis. First, the key applications of the micro-nanorobotic manipulation system in single cell analysis are introduced, including the single cell injection, positioning, characterization, assembly, and the development of biomedical device. Then, the current key techniques, challenges, and future trends in micro-nanorobot are discussed from the aspects of actuating, sensing, controlling, system integration, and commercialization. To meet the requirement of cell biology, the next generation micro-nanorobot should have small, automatic, high integration and applicable features in multiscale.

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“…Conventionally, for measuring the penetration force of embryos or oocytes, an injection micropipette is bonded to the free end of a compliant cantilever covered with sensitive films (e.g., [1], [3], [4]). The pressure tube which is connected to the micropipette for the delivery of liquid samples can however affect the penetration force measurement [5].…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of a novel resonant surface sensitive to out-of-plane forces for the indentation and injection of living cells

Desmaële

Boukallel

Régnier

2011

2011 IEEE/RSJ International Conference on Intelligent Robots and Systems

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Abstract-We present a novel force sensor for cell indentation and cell injection. This force sensor is a monolithic structure that integrates two resonators. It provides a surface sensitive to out-of-plane forces where a living cell can be conveniently placed for manipulation. Normal forces applied upon the cell under study are estimated via frequency shifts of the resonators. In this paper, we develop a theoretical study for predicting and optimizing the structure's sensitivity. As a proof of concept, we also report the fabrication and experimental characterization of a first prototype. In ambient conditions, our prototype presently offers a quality factor of ∼700, and a linear sensitivity of ∼5.75 Hz /µm. In addition, we report the implementation of a compact and low-cost optical fiber setup to monitor the resonators' frequency. Potential applications are illustrated with the measurement of forces applied on lobster eggs.

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Force Feedback Interface for Cell Injection

Cited by 38 publications

References 53 publications

Haptic Feedback for Microrobotics Applications: A Review

Haptic Feedback for Microrobotics Applications: A Review

State of the art: micro-nanorobotic manipulation in single cell analysis

Design and fabrication of a novel resonant surface sensitive to out-of-plane forces for the indentation and injection of living cells

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