PURPOSE-As the mean age of the US population increases, the public health burden of osteoporotic fractures is expected to increase. This study prospectively examined the independent association of hip circumference with hip fracture.
METHODS-The prospective association of hip circumference and hip fracture was examined in a cohort of 30,652 postmenopausal women.RESULTS-Compared to the lowest quintile, successive quintiles of hip circumference were associated with a reduced hazard of hip fracture over 18 years of follow-up (HRs = 1.00, 0.78, 0.74, 0.76, 0.69, p for trend = 0.0015) after adjusting for age. Controlling for waist, this association persisted (HRs = 1.00, 0.78, 0.73, 0.72, 0.54, p for trend = 0.0006). Additionally controlling for BMI, the association of hip fracture with hip circumference was attenuated to the null while the association with successive quintiles of BMI remained significant and inverse (HRs = 1.00, 0.55, 0.45, 0.40, 0.35, p for trend <0.0001).CONCLUSIONS-Although hip circumference has a strong inverse association with risk of hip fracture, this association was not independent of BMI. These results suggest that in the prediction of hip fracture risk, overall body size may be more important than body composition of the femoralgluteal region.
Keywordsanthropometry; hip fractures; cohort studies
PURPOSEAging of the US population will be an important occurrence in the coming decades. As the mean population age increases, the public health burden of osteoporotic fractures is expected to rise, which will have a profound impact on subsequent functional limitations 1,2 , disability, morbidity 2 and mortality 2,3 in older populations. Furthermore, given population increases in overweight and obesity, it is important to further our understanding of adiposity and body shape and hip fracture. This study examined the association of hip circumference, independent of waist circumference and body mass index (BMI), with risk of fractures in postmenopausal women in the Iowa Women's Health Study (IWHS). We hypothesized that women with larger hip circumferences will have a reduced risk of hip fracture over follow-up compared to women with smaller hip circumferences, after controlling for waist circumference, BMI and other risk factors.
METHODSThe IWHS is a prospective cohort study of lifestyle risk factors and chronic diseases in postmenopausal women.
Data collectionThe baseline questionnaire included standard questions on demographic information, behavioral and lifestyle factors, and personal medical history. Women were asked to report education level, age, and marital status. The questionnaire included three questions about participation in leisure time physical activity and the frequency of moderate-and heavyintensity activities. These latter two questions were combined to create a 3-level activity score (low, moderate, and high). A food frequency questionnaire was included to ascertain usual diet and alcohol consumption over the past year 7 . Women were asked about smoking status and pack year...