For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

Bilgin, Elif; Dizdar, Yavuz; Serilmez, Murat; Soydinc, Hilal Oguz; Yasasever, Ceren Tilgen; Duranyıldız, Derya; Yasasever, Vildan

doi:10.7314/apjcp.2013.14.4.2541

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…Another finding of our study is that serum CEA in patients with lung cancer were significantly higher than those with benign disease and healthy controls (p< 0.05), indicating that CEA could be used in early diagnosis of lung cancer. CA19-9 tumor associated antigen is commonly used in patient with pancreas, liver, and colorectal cancers .Now, it is confirmed that CA199 is an important marker in diagnosis of lung cancer, and the sensitivity in detecting lung cancer was 43.76%, specificity was 78.34% (Bilgin et al, 2013). In this study, serum CA199 in patients with lung cancer were significantly higher than those with lung benign disease and healthy controls (p< 0.05), suggesting CA199 is of importance in the diagnosis of lung cancer.…”

Section: Discussionmentioning

confidence: 55%

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Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination

Wang¹,

Tao²,

Gu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objective: To evaluate the association of a diagnosis of lung cancer and combined detection of serum carcinoembryonic antigen (CEA), carbohydrateantigen 19-9 (CA19-9), neuron specific enolase (NSE) as well as the cytokeratin 19 fragment (CYFRA21-1). Methods: Serum CEA, CA19-9, NSE and CYFRA21-1 were assessed in 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of lung cancer were analyzed. Results: Serum CEA, CA19-9, NSE and CYFRA21-1 in patients with lung cancer were significantly higher than those with benign lung disease and normal controls (p<0.01). It is suggested that these four tumor markers combined together could produce a positive detection rate of 90.2%, significantly higher than that of any single test. Conclusion: Combination detection of CEA, CA19-9, NSE and CYFRA21-1 could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be important in early detection.

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Section: Discussionmentioning

confidence: 55%

“…NSE is an important tumor marker for neuroblastoma and small cell lung cancer (Bilgin et al, 2013). Current study suggested that the sensitivity of NSE in detection of lung cancer was 52.78%, and the specificity was 84.52%.…”

Section: Discussionmentioning

confidence: 85%

Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination

Wang¹,

Tao²,

Gu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Reactivity is observed to be lower in frequency and intensity when compared to vimentin. SMA reactivity has also been reported 26 . The smooth muscle isoform of SMA is routinely expressed by pilar and vascular smooth muscle reactive myofibroblasts, a subset of pericytes and myoepithelial cells.…”

Section: Discussionmentioning

confidence: 86%

Immunohistochemistry and antigenic expression of four proteins in Kaposi Sarcoma

Egbujo

Adisa

Egbujo

et al. 2013

Int J of Biomed & Adv Res

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Introduction: Kaposi sarcoma poses problems in histological diagnosis because of its broad morphologic variants and similarity to many vasoproliferative lesions. Establishing diagnosis on the basis of tumour marker alone (especially a single result) is fraught with associated pitfalls because of the problem of non- specificity.

Method: Fifteen(15) Kaposi sarcoma biopsies from seven(7) men and eight(8) women were used to find out the gene expression of vimentin, desmin, smooth muscle actin(SMA), S-100 and neuron specific enolase(NSE) in Kaposi sarcoma, Haematoxylin and eosin(H&E) method was used to confirm the diagnosis of Kaposi sarcoma in archival processed biopsies. Subsequently, Immunohistochemistry(IHC) was carried out to find out the expression of the antibodies listed.

Results: Vimentin and SMA were found to be most reactive. Neuron specific enolase were mildly reactive while the rest were non-reactive.

Conclusion: Only vimentin and SMA offer significant reactivity in the diagnosis of Kaposi sarcoma and are useful in undifferentiated neoplasms.

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“…Overall, based on recent literature findings, NSE serum levels appear to be inaccurate in discriminating between PCa and benign prostatic disease. Two studies did not find any differences (17,31), whereas another 2, showing differences in serum NSE between PCa and benign tissue, used mixed stages of tumors (21,23). However, there seems to be a greater number of patients, from 30% to 37%, having elevated levels of serum NSE at diagnosis of progressive CRPC (20,27,33,34).…”

Section: Discussionmentioning

confidence: 96%

“…No additional studies were found in screening the references of those selected articles. Finally, 19 articles including 1,772 patients with confirmed or suspicious PCa were selected for the systematic review (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) (Fig. 1).…”

Section: Literature Searchmentioning

confidence: 99%

The role of serum neuron-specific enolase in patients with prostate cancer: a systematic review of the recent literature

2017

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In this systematic review, we evaluated the value of serum concentrations of neuron-specific enolase (NSE) in patients with prostate cancer (PCa) in order to clarify the possible role of NSE in the diagnosis, management, treatment and monitoring of PCa. A comprehensive search of the recent literature was conducted to find relevant data on the role of NSE in PCa. Two hundred and eighty-two records were revealed, and 19 articles including 1,772 patients with PCa (either confirmed or suspected) were selected. After reviewing the articles, the major result was that elevated serum NSE appears to correlate with prognosis in advanced PCa, particularly in patients with progressive and metastatic castration-resistant PCa. Based on the existing literature, the role of serum NSE in PCa patients should be further evaluated.

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For Which Cancer Types can Neuron-Specific Enolase be Clinically Helpful in Turkish Patients?

Cited by 5 publications

References 24 publications

Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination

Clinical Observations on the Association Between Diagnosis of Lung Cancer and Serum Tumor Markers in Combination

Immunohistochemistry and antigenic expression of four proteins in Kaposi Sarcoma

The role of serum neuron-specific enolase in patients with prostate cancer: a systematic review of the recent literature

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