Foot massage evokes oxytocin release and activation of orbitofrontal cortex and superior temporal sulcus

Li, Qin; Becker, Benjamin; Wernicke, Jennifer; Chen, Yuanshu; Zhang, Yingying; Li, Rui; Le, Jiao; Kou, Juan; Zhao, Weihua; Kendrick, Keith M.

doi:10.1016/j.psyneuen.2018.11.016

Cited by 58 publications

(78 citation statements)

References 82 publications

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“…Despite a lack of between-group differences in the subjective liking of the task, an exploratory correlational analysis revealed that stronger training-induced lOFC increases in the experimental group associated with higher post-training liking ratings whereas no such association was observed in the sham group. These findings are in line with a previous report on a positive association between lOFC activation and subjective liking during a social reward paradigm [54] and the important role of the lOFC in processing reward-related outcome expectancies [61].…”

Section: Discussionsupporting

confidence: 93%

“…Given that a previous study reported significant associations between fNIRS-assessed OFC activity and liking levels [54], associations with post-training liking ratings were additionally explored. Results indicated that the liking level was significantly positively associated with OFC activation changes in the training (rexperimental =0.506, p = 0.007 see figure 6B), but not the sham control group (rcontrol = 0.034, p = 0.861, marginal significant betweengroup correlation differences, z = 1.87, p = 0.062; see figure 6B).…”

Section: Association Between Behavioural and Neural Training Successmentioning

confidence: 99%

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Functional Near-Infrared Spectroscopy (fNIRS) informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility

Jiang

Gong

et al. 2019

Preprint

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Cognitive flexibility and reward processing critically rely on the orbitofrontal cortex.Dysregulations in these domains and orbitofrontal activation have been reported in major psychiatric disorders. Haemodynamic brain imaging informed neurofeedback allows regional-specific control over brain activation and thus may represent an innovative intervention to regulate orbitofrontal dysfunctions. Against this background the present proof-of-concept study evaluated the feasibility and behavioral relevance of functional Near-Infrared Spectroscopy (fNIRS) assisted neurofeedback training of the lateral orbitofrontal cortex (lOFC). In a randomized sham-controlled between-subject design 60 healthy participants underwent four subsequent runs of training to enhance lOFC activation.Training-induced changes in the lOFC, attentional set shifting performance and reward experience served as primary outcomes. Feedback from the target channel significantly increased regional-specific lOFC activation over the four training runs in comparison with sham feedback. The experimental group demonstrated a trend for faster responses during set shifting relative to the sham group. Within the experimental group stronger traininginduced lOFC increases were associated with higher reward experience. The present results demonstrate that fNIRS-informed neurofeedback allows regional-specific regulation of lOFC activation and may have the potential to modulate associated behavioral domains. As such fNIRS-informed neurofeedback may represent a promising strategy to regulate OFC dysfunctions in psychiatric disorders.

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Section: Discussionsupporting

confidence: 93%

Section: Association Between Behavioural and Neural Training Successmentioning

confidence: 99%

Functional Near-Infrared Spectroscopy (fNIRS) informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility

Jiang

Gong

et al. 2019

Preprint

Self Cite

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“…It is unknown whether salivary oxytocin increase corresponds to the change in the brain activity in a linear way, but it can be expected that the neural effects of conditioned oxytocin release might be much smaller than the effects of oxytocin administration. However, even small natural variations of the endogenous oxytocin levels have been shown to affect brain activity, for example, in resting state [51], during massage [52], and in response to aversive stimuli [53]. Therefore, it could be expected that endogenous oxytocin release triggered by conditioning, would be strong enough to affect brain activity.…”

Section: Plos Onementioning

confidence: 99%

Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study

et al. 2020

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It has been demonstrated that secretion of several hormones can be classically conditioned, however, the underlying brain responses of such conditioning have never been investigated before. In this study we aimed to investigate how oxytocin administration and classically conditioned oxytocin influence brain responses. In total, 88 females were allocated to one of three groups: oxytocin administration, conditioned oxytocin, or placebo, and underwent an experiment consisting of three acquisition and three evocation days. Participants in the conditioned group received 24 IU of oxytocin together with a conditioned stimulus (CS) during three acquisition days and placebo with the CS on three evocation days. The oxytocin administration group received 24 IU of oxytocin and the placebo group received placebo during all days. On the last evocation day, fMRI scanning was performed for all participants during three tasks previously shown to be affected by oxytocin: presentation of emotional faces, crying baby sounds and heat pain. Region of interest analysis revealed that there was significantly lower activation in the right amygdala and in two clusters in the left superior temporal gyrus in the oxytocin administration group compared to the placebo group in response to observing fearful faces. The activation in the conditioned oxytocin group was in between the other two groups for these clusters but did not significantly differ from either group. No group differences were found in the other tasks. Preliminary evidence was found for brain activation of a conditioned oxytocin response; however, despite this trend in the expected direction, the conditioned group did not significantly differ from other groups. Future research should, therefore, investigate the optimal timing of conditioned endocrine responses and study whether the findings generalize to other hormones as well. PLOS ONEPLOS ONE | https://doi.org/10.

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“…It is the belief of the authors that ignoring these differences, and using different techniques interchangeably, only leads to confusion in the field of research in oriental bodywork, making it more difficult to assess the evidence. Moreover, the few studies which have addressed the question of the effects of different methods of mechanical stimulation, suggest that different types of mechanical stimulation do not have the same or similar physiological effects [10][11][12].…”

Section: Objectivesmentioning

confidence: 99%

“…In fact, the opposite seems to be the case. Manual foot massage can activate the posterior superior temporal sulcus in the brain while machine massage cannot [10]. The effect of kneading or rotating around a point is not the same as applying stationary pressure, and the effect of self-applying pressure cannot be used as evidence when the pressure is applied by a different person, unless studies to prove the same physiological effects are conducted.…”

Section: Acupressurementioning

confidence: 99%

Similarities and Differences in East Asian Massage and Bodywork Therapies: A Critical Review

Cabo¹,

Aguaristi²

2020

OBM ICM

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Several manual bodywork therapies that originated in Asia are related to the theory and practice of acupuncture and Traditional Chinese Medicine (TCM). One of the aims of these therapies is to stimulate specific points on the body called acupoints which are the same points in which needles are inserted in acupuncture. These manual therapies, however, vary in their interpretation and explanation of the theories of TCM, and even more so, in the practical way the stimulation is applied. The aim of this paper is to clarify these differences and show how future research can benefit from specifying the actual techniques used. This paper analyses and compares research papers, textbooks, articles, official definitions and demonstrations of the techniques to highlight the similarities and differences, and examines instances in research in which the techniques were not clearly differentiated. There are many instances in the research literature in which references from one of these practices, or from acupuncture itself, has been used as evidence for other manual therapies conflating the evidence. As far as it is known, nobody has proved that inserting a needle or applying electric stimulation on a specific point on the body has the same physiological effects as pressing with a finger. Nobody has proved that applying stationary pressure has the same

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Foot massage evokes oxytocin release and activation of orbitofrontal cortex and superior temporal sulcus

Cited by 58 publications

References 82 publications

Functional Near-Infrared Spectroscopy (fNIRS) informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility

Functional Near-Infrared Spectroscopy (fNIRS) informed neurofeedback: regional-specific modulation of lateral orbitofrontal activation and cognitive flexibility

Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study

Similarities and Differences in East Asian Massage and Bodywork Therapies: A Critical Review

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