Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study

Skvortsova, Aleksandrina; Veldhuijzen, Dieuwke S.; Rover, Mischa de; Pacheco-López, Gustavo; Bakermans‐Kranenburg, Marian J.; IJzendoorn, Marinus van; Chavannes, Niels H.; Middendorp, Henriët van; Evers, Andrea W M

doi:10.1371/journal.pone.0229692

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…Conversely, Quintana et al [ 57 ] concluded that men who received oxytocin rated ambiguous faces with lower intensity only in the case of anger, compared to a placebo condition [ 57 ]. The rest of the studies failed to report significant results for changes in rating the intensity or arousal of facial emotional expressions [ 31 , 50 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing

Romero‐Martínez

Sarrate-Costa

Moya-Albiol

2021

Biology

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A topic of interest is the way decoding and interpreting facial emotional expressions can lead to mutual understanding. Facial emotional expression is a basic source of information that guarantees the functioning of other higher cognitive processes (e.g., empathy, cooperativity, prosociality, or decision-making, among others). In this regard, hormones such as oxytocin, cortisol, and/or testosterone have been found to be important in modifying facial emotion processing. In fact, brain structures that participate in facial emotion processing have been shown to be rich in receptors for these hormones. Nonetheless, much of this research has been based on correlational designs. In recent years, a growing number of researchers have tried to carry out controlled laboratory manipulation of these hormones by administering synthetic forms of these hormones. The main objective of this study was to carry out a systematic review of studies that assess whether manipulation of these three hormones effectively promotes significant alterations in facial emotional processing. To carry out this review, PRISMA quality criteria for reviews were followed, using the following digital databases: PsycINFO, PubMed, Dialnet, Psicodoc, Web of Knowledge, and the Cochrane Library, and focusing on manuscripts with a robust research design (e.g., randomized, single- or double-blind, and/or placebo-controlled) to increase the value of this systematic review. An initial identification of 6340 abstracts and retrieval of 910 full texts led to the final inclusion of 101 papers that met all the inclusion criteria. Only about 18% of the manuscripts included reported a direct effect of hormone manipulation. In fact, emotional accuracy seemed to be enhanced after oxytocin increases, but it diminished when cortisol and/or testosterone increased. Nonetheless, when emotional valence and participants’ gender were included, hormonal manipulation reached significance (in around 53% of the articles). In fact, these studies offered a heterogeneous pattern in the way these hormones altered speed processing, attention, and memory. This study reinforces the idea that these hormones are important, but not the main modulators of facial emotion processing. As our comprehension of hormonal effects on emotional processing improves, the potential to design good treatments to improve this ability will be greater.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing

Romero‐Martínez

Sarrate-Costa

Moya-Albiol

2021

Biology

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“…Oxytocin has been shown to reduce amygdala activity and be the underlying mechanism for stress reduction [18]. Babies who suck well stimulate the release of oxytocin more efficiently, as expressed by a high variance of oxytocin, which leads to a better stimulation of milk production.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Stimulation Massage (PSO) Is Effective in Overcoming the Anxiety of Breastfeeding Mothers and Promoting Milk Production

Kartilah¹,

Februanti²

2023

Advances in Social Science, Education and Humanities Research

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Breastfeeding is a natural process in the mother's reproductive cycle that needs to be maintained for its quality and continuity for 2 years since the baby is born. Postpartum psychological changes and feelings of not being able to breastfeed properly encourage an increase in adrenaline production which follows maternal anxiety and increases adrenaline so that it suppresses the activity of oxytocin and prolactin to produce breast milk. The purpose of this study was to determine the effect of oxytocin stimulating massage (PSO) on reducing maternal anxiety and smooth milk production. The research design used a quasiexperimental without control. The sample is 27 people, using a random sampling technique. The research was conducted in the working area of the Cihideung Public Health Center, Tasikmalaya, Indonesia. The results showed that there was a significant difference in the average anxiety score of breastfeeding mothers between before and after PSO therapy (r = 0.0001 (r < 0.05)) and there was a significant difference in the average percentage of smooth milk production in breastfeeding mothers between before and after PSO therapy (r = 0.0001 (r < 0.05)).

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“…Group C was given nasal saline after delivery. Group O was immediately given 24IU of oxytocin nasal spray [9] (Sichuan Defeng Pharmaceutical Co., LTD.).…”

Section: Grouping and Processingmentioning

confidence: 99%

The effect and mechanism of oxytocin nasal spray on postpartum depression in primipara

2023

IJFM

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The purpose of this article is to investigate the effect and possible mechanism of oxytocin (OT) intranasal on depression after cesarean section in primipara. A total of 188 puerperae who underwent first cesarean section operation under spinal anesthesia in our hospital from February 2021 to February 2022 were selected and divided into two groups according to 1:1 by random number table method, the control group (group C) and the Oxytocin group (group O), 94 cases in each group. Group C was given nasal saline after delivery. Group O was immediately given 24IU of oxytocin nasal spray. The Edinburgh postnatal depression scale (EPDS) was used to evaluate the depression status of patients at 1 day before delivery (T0), 3 days after delivery (T1), 5 days (T2) and 6 weeks (T3), while using ELISA The serum corticotropin-releasing factor (CRF) and cortisol levels were detected at T0, T1, T2 and T3. Arrhythmias, nasal irritation, and tears were recorded after the intervention. Compared with group C, the incidence of postpartum depression, EPDS score, CRF and cortisol concentration in group O at T1 and T2 were significantly decreased, and the difference was statistically significant (P < 0.05). Compared with T0, EPDS score, CRF and cortisol concentration of patients in 2 groups were significantly increased at T1, T2 and T3, with statistical significance (P <0.05). There was no arrhythmia, nasal irritation or tearing after intervention in both groups. The use of oxytocin nasal spray after delivery of the fetus during cesarean section can reduce depressive symptoms at 3 and 5 days postpartum, serum CRF and cortisol concentrations in first-time mothers without increasing the incidence of adverse reactions.

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Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study

Cited by 7 publications

References 56 publications

A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing

A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing

Oxytocin Stimulation Massage (PSO) Is Effective in Overcoming the Anxiety of Breastfeeding Mothers and Promoting Milk Production

The effect and mechanism of oxytocin nasal spray on postpartum depression in primipara

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