Foot-and-Mouth Disease Virus Serotype SAT 3 in Long-Horned Ankole Calf, Uganda

Dhikusooka, Moses Tefula; Tjørnehøj, Kirsten; Ayebazibwe, Chrisostom; Namatovu, Alice; Ruhweza, Simon Peter; Siegismund, Hans R.; Wekesa, Sabenzia Nabalayo; Normann, Preben; Belsham, Graham J.

doi:10.3201/eid2101.140995

Cited by 21 publications

(27 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further studies may be warranted to also include serotypes C and SAT 3, although serotype C has not been detected in any country since 2004. SAT 3‐specific antibodies have been recorded in sera from west and central Africa (Ehizibolo et al., ; Ludi et al., ) and from eastern Africa (Ayebazibwe et al., ; Dhikusooka et al., ; Mwiine et al., ; Namatovu et al., ), although this serotype has not previously been detected in Niger. Although the sampling strategy is different to that implemented by Ludi et al.…”

Section: Discussionmentioning

confidence: 99%

Outbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in south-west Niger

Kouato

Elliot

King

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Outbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in south-west Niger

Kouato

Elliot

King

et al. 2017

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…The need for repeated vaccination and the lack of sufficient quality vaccine of the appropriate strain composition slows the progression of vaccine‐based FMD control programs. In recent years, the genetic diversity and co‐circulation of multiple FMDV serotypes (O, A, SAT 1, SAT 2) (Ayebazibwe, Mwiine, Tjørnehøj, et al, ; Mwiine et al, ; Namatovu, Belsham, et al, ; Namatovu, Tjørnehøj, et al, ; Wekesa et al, , ) and SAT 3 in Eastern Africa has become evident (Dhikusooka et al, ). This study aimed to determine the seroprevalence of FMDV across eastern, central, western and northern regions of Uganda, as well as to identify the serotypes and phylogenetic characteristics of FMDV circulating in this country.…”

Section: Discussionmentioning

confidence: 99%

Serological and phylogenetic characterization of foot and mouth disease viruses from Uganda during cross‐sectional surveillance study in cattle between 2014 and 2017

Mwiine

Velazquez‐Salinas

Ahmed

et al. 2019

Transbound Emerg Dis

View full text Add to dashboard Cite

Here, we report the results of a cross-sectional study designed to monitor the circulation and genetic diversity of foot and mouth disease virus (FMDV) in Uganda between 2014 and 2017. In this study, 13,614 sera and 2,068 oral-pharyngeal fluid samples were collected from cattle and analysed to determine FMDV seroprevalence, circulating serotypes and their phylogenetic relationships. Circulation of FMDV was evidenced by the detection of antibodies against non-structural proteins of FMDV or viral isolations in all districts sampled in Uganda. Sequence analysis revealed the presence of FMDV serotypes A, O, SAT 1 and SAT 2. FMDVs belonging to serotype O, isolated from 21 districts, were the most prevalent and were classified into six lineages within two East African topotypes, namely EA-1 and EA-2. Serotype A viruses belonging to the Africa G-I topotype were isolated from two districts. SAT 1 viruses grouped within topotypes I and IV and SAT 2 viruses within topotypes VII, IV and X were isolated from six and four districts respectively. Phylogenetic analysis of SAT 1 and SAT 2 sequences from cattle clustered with historical sequences from African buffalo, indicating possible interspecies transmission at the wildlife-livestock interface. In some cases, Uganda viruses also shared similarities to viral strains recovered from other regions in East Africa. This 3-year study period provides knowledge about the geographical distribution of FMDV serotypes isolated in Uganda and insights into the genetic diversity of the multiple serotypes circulating in the country. Knowledge of circulating FMDV viruses will assist in antigenic matching studies to devise improved FMDV control strategies with vaccination and vaccine strain selection for Uganda. K E Y W O R D Sbuffalo, EA-2, foot and mouth disease, molecular epidemiology, Uganda, vaccine

show abstract

“…Finally, although most outbreaks in cattle result from transmission within and between livestock populations, buffalo may still be a source of novel lineages to which current vaccines are inefficacious. For example, distinct SAT1 viruses as well as serotype SAT3, which was hitherto thought not to be present in Uganda, were isolated from cattle living in proximity to buffalo in western Uganda (Dhikusooka et al, , ).…”

Section: Discussionmentioning

confidence: 99%

Phylogeographical and cross‐species transmission dynamics of SAT1 and SAT2 foot‐and‐mouth disease virus in Eastern Africa

et al. 2019

View full text Add to dashboard Cite

Understanding the dynamics of foot-and-mouth disease virus (FMDV), an endemic and economically constraining disease, is critical in designing control programmes in Africa. This study investigates the evolutionary epidemiology of SAT1 and SAT2 FMDV in Eastern Africa, as well as between cattle and wild African buffalo. Bayesian phylodynamic models were used to analyse SAT1 and SAT2 VP1 gene segments collected between 1975 and 2016, focusing on the SAT1 and SAT2 viruses currently circulating in Eastern Africa. The root state posterior probabilities inferred from our analyses suggest Zimbabwe as the ancestral location for SAT1 currently circulating in Eastern Africa (p = 0.67). For the SAT2 clade, Kenya is inferred to be the ancestral location for introduction of the virus into other countries in Eastern Africa (p = 0.72).Salient (Bayes factor >10) viral dispersal routes were inferred from Tanzania to Kenya, and from Kenya to Uganda for SAT1 and SAT2, respectively. Results suggest that cattle are the source of the SAT1 and SAT2 clades currently circulating in Eastern Africa.In addition, our results suggest that the majority of SAT1 and SAT2 in livestock come from other livestock rather than wildlife, with limited evidence that buffalo serve as reservoirs for cattle. Insights from the present study highlight the role of cattle movements and anthropogenic activities in shaping the evolutionary history of SAT1 and SAT2 in Eastern Africa. While the results may be affected by inherent limitations of imperfect surveillance, our analysis elucidates the dynamics between host species in this region, which is key to guiding disease intervention activities. K E Y W O R D Sancestral reconstruction, FMD, interspecific transmission, molecular epidemiology, phylodynamics, wildlife-livestock interfaces

show abstract

Foot-and-Mouth Disease Virus Serotype SAT 3 in Long-Horned Ankole Calf, Uganda

Cited by 21 publications

References 12 publications

Outbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in south-west Niger

Outbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in south-west Niger

Serological and phylogenetic characterization of foot and mouth disease viruses from Uganda during cross‐sectional surveillance study in cattle between 2014 and 2017

Phylogeographical and cross‐species transmission dynamics of SAT1 and SAT2 foot‐and‐mouth disease virus in Eastern Africa

Contact Info

Product

Resources

About