“…Infection of FMDV causes a highly contagious and economically important disease in cloven-hoofed animals, including cattle, pigs, sheep and goats; this disease is characterized by vesicular lesions in the mouth and on the feet, teats and nares (Sen and Saha, 1994;Brown, 1999;Balamurugan et al, 2004;Grubman and Baxt, 2004;Arzt et al, 2011). FMDV has a dual capacity to induce either an acute infection in clovenhooved animals, or an inapparent, persistent infection in ruminants (Brown, 1999;Grubman and Baxt, 2004;Mahy, 2005). FMDV usually becomes immediately cytopathic to the cultured cells, in which it can also establish a long-term persistent infection (de la Torre et al, 1985;Huang et al, 2011).…”