Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains

Gabriël, Sarah; Dorny, Pierre; Saelens, Ganna; Dermauw, Véronique

doi:10.3390/foods12010142

Cited by 22 publications

(17 citation statements)

References 156 publications

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“…Compared with some chemical sensors or nanomaterialbased analysis methods, the nanochannel sensor prepared by this method has a lower detection limit and can realize the detection and recovery of PPi in East Lake water samples, with a recovery rate of 87.0−109.4%, which is expected to develop into a technology for rapid detection of PPi in environmental water samples in situ. In addition, the team early introduced isoniazid functionalized calix [4]arene (C4NP) into the biomimetic nanochannels, and constructed potassium channels selectively recognized by pyrophosphate (PPi) based on the changes in charge and affinity of the channel surface. 93 Similarly, in another study, Xue et al 94 achieved a simple and rapid detection of Zr−O−P coordination bond-based phosphate by growing zirconium-based metal-based organic frameworks (Zr-MOFs) in situ on the surface of the nanochannels, with the detection limit of 4.0 fM.…”

Section: Detection Of Additives In Foodmentioning

confidence: 99%

“…Quality and safety of food are related to the health and life safety of the people. The current food safety hazards include biohazards (pathogenic bacteria, bioamines, viruses, parasites) and chemical hazards (food additives, formaldehyde, heavy metals, organic pollutants), − which pose a serious threat to humans. Among them, the bacteria in biological hazards can cause food spoilage and foodborne diseases. ,,− Viruses are usually transmitted to food by direct or indirect excretion.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances of Food Hazard Detection Based on Artificial Nanochannel Sensors

Xu,

Li,

et al. 2024

J. Agric. Food Chem.

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Food quality and safety are related to the health and safety of people, and food hazards are important influencing factors affecting food safety. It is strongly necessary to develop food safety rapid detection technology to ensure food safety. As a new detection technology, artificial nanochannel-based electrochemical and other methods have the advantages of being real-time, simple, and sensitive and are widely used in the detection of food hazards. In this paper, we review artificial nanochannel sensors as a new detection technology in food safety for different types of food hazards: biological hazards (bacteria, toxins, viruses) and chemical hazards (heavy metals, organic pollutants, food additives). At the same time, we critically discuss the advantages and disadvantages of artificial nanochannel sensor detection, as well as the restrictions and solutions of detection, and finally look forward to the challenges and development prospects of food safety detection technology based on the limitations of artificial nanochannel detection. We expect to provide a theoretical basis and inspiration for the development of rapid real-time detection technology for food hazards and the production of portable detection equipment in the future.

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Section: Detection Of Additives In Foodmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances of Food Hazard Detection Based on Artificial Nanochannel Sensors

Xu,

Li,

et al. 2024

J. Agric. Food Chem.

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“…Following mating, new larvae progenies move to the muscle. Depending on the number of infective larvae ingested, symptomatology ranges from mild (fatigue, weakness, fever, diarrhoea, muscle pains) to severe (heart or breathing problems and, rarely, death) (Franssen et al., 2021 ; Gabriel et al., 2023 ). Symptoms appear from 1 to 2 days after consumption until 2–8 weeks after treatment (European Centre for disease control (ECDC 6 )).…”

Section: Assessmentmentioning

confidence: 99%

Assessment on the efficacy of methods 2 to 5 and method 7 set out in Commission Regulation (EU) No 142/2011 to inactivate relevant pathogens when producing processed animal protein of porcine origin intended to feed poultry and aquaculture animals

Koutsoumanis¹,

Allende²,

Ordóñez³

et al. 2023

EFS2

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An assessment was conducted on the level of inactivation of relevant pathogens that could be present in processed animal protein of porcine origin intended to feed poultry and aquaculture animals when methods 2 to 5 and method 7, as detailed in Regulation (EU) No 142/2011, are applied. Five approved scenarios were selected for method 7. Salmonella Senftenberg, Enterococcus faecalis, spores of Clostridium perfringens and parvoviruses were shortlisted as target indicators. Inactivation parameters for these indicators were extracted from extensive literature search and a recent EFSA scientific opinion. An adapted Bigelow model was fitted to retrieved data to estimate the probability that methods 2 to 5, in coincidental and consecutive modes, and the five scenarios of method 7 are able to achieve a 5 log10 and a 3 log10 reduction of bacterial indicators and parvoviruses, respectively. Spores of C. perfringens were the indicator with the lowest probability of achieving the target reduction by methods 2 to 5, in coincidental and consecutive mode, and by the five considered scenarios of method 7. An expert knowledge elicitation was conducted to estimate the certainty of achieving a 5 log10 reduction of spores of C. perfringens considering the results of the model and additional evidence. A 5 log10 reduction of C. perfringens spores was judged: 99–100% certain for methods 2 and 3 in coincidental mode; 98–100% certain for method 7 scenario 3; 80–99% certain for method 5 in coincidental mode; 66–100% certain for method 4 in coincidental mode and for method 7 scenarios 4 and 5; 25–75% certain for method 7 scenario 2; and 0–5% certain for method 7 scenario 1. Higher certainty is expected for methods 2 to 5 in consecutive mode compared to coincidental mode.

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“…leading to the emergence of severe clinical manifestations. Tissue cysts are a major source of transmission via the consumption of undercooked meat from infected animals ( Gabriël et al, 2022 ). Hence, the investigation of bradyzoite biology including chemotherapy development is much needed.…”

Section: Introductionmentioning

confidence: 99%

Generation of Mature <em>Toxoplasma gondii</em> Bradyzoites in Human Immortalized Myogenic KD3 Cells

Maus,

Curtis,

Warschkau

et al. 2024

BIO-PROTOCOL

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Toxoplasma gondii is a zoonotic protozoan parasite and one of the most successful foodborne pathogens. Upon infection and dissemination, the parasites convert into the persisting, chronic form called bradyzoites, which reside within cysts in muscle and brain tissue. Despite their importance, bradyzoites remain difficult to investigate directly, owing to limited in vitro models. In addition, the need for new drugs targeting the chronic stage, which is underlined by the lack of eradicating treatment options, remains difficult to address since in vitro access to drug-tolerant bradyzoites remains limited. We recently published the use of a human myotube-based bradyzoite cell culture system and demonstrated its applicability to investigate the biology of T. gondii bradyzoites. Encysted parasites can be functionally matured during long-term cultivation in these immortalized cells and possess many in vivo–like features, including pepsin resistance, oral infectivity, and antifolate resistance. In addition, the system is scalable, enabling experimental approaches that rely on large numbers, such as metabolomics. In short, we detail the cultivation of terminally differentiated human myotubes and their subsequent infection with tachyzoites, which then mature to encysted bradyzoites within four weeks at ambient CO2 levels. We also discuss critical aspects of the procedure and suggest improvements. Key features • This protocol describes a scalable human myotube-based in vitro system capable of generating encysted bradyzoites featuring in vivo hallmarks. • Bradyzoite differentiation is facilitated through CO 2 depletion but without additional artificial stress factors like alkaline pH. • Functional maturation occurs over four weeks.

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Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains

Cited by 22 publications

References 156 publications

Recent Advances of Food Hazard Detection Based on Artificial Nanochannel Sensors

Recent Advances of Food Hazard Detection Based on Artificial Nanochannel Sensors

Assessment on the efficacy of methods 2 to 5 and method 7 set out in Commission Regulation (EU) No 142/2011 to inactivate relevant pathogens when producing processed animal protein of porcine origin intended to feed poultry and aquaculture animals

Generation of Mature <em>Toxoplasma gondii</em> Bradyzoites in Human Immortalized Myogenic KD3 Cells

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