Food-Specific Serum IgG4 and IgE Titers to Common Food Antigens in Irritable Bowel Syndrome

Zar, Sameer; Benson, Martin; Kumar, Devinder

doi:10.1111/j.1572-0241.2005.41348.x

Cited by 106 publications

(77 citation statements)

References 26 publications

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“…At the current level of knowledge, determining the concentration of IgG in the serum of patients with IBS is not justified. Results obtained in this study confirm reports by other authors, both those already published in the 1990s [9][10][11], and the latest [12,13], although some researchers have recognized the benefits of testing serum IgG concentration in IBS patients [14][15][16]. Kruszewski et al [10,11] also found that elevated levels of IgG are equally common in healthy people and people who are allergic.…”

Section: Discussionsupporting

confidence: 82%

Concentration of IgG antibodies against food allergens in patients with irritable bowel syndrome and healthy individuals

Traczyk¹,

M²,

Tomasiuk³

et al. 2011

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Introduction: In recent years the hypothesis that irritable bowel syndrome (IBS) symptoms result from allergies or food intolerance which have not been identified has been gaining more and more supporters. Attempts are being made to find a connection between the symptoms identified in patients with IBS and food allergy, particularly IgG-dependent. The results obtained do not give a definite answer. Aim: Evaluation the usefulness of tests for immunoglobulin G (IgG) in patients with IBS against food allergens and the possible use of the obtained results for the introduction of an elimination diet. Material and methods: The study included 100 patients with IBS treated at the Gastrological Clinic of Brodnowski Regional Hospital in Warsaw. The control group consisted of 50 healthy individuals. IgG antibodies in the serum were tested against eight mixes of food allergens The concentration of antibodies was examined by an enzyme immunoassay test. Calculations were performed in Stata v.10. Results: Positive tests denoting the concentrations were found in more than 90% of patients with IBS. For the three tested mixtures of allergens, all the results were positive, and the remaining positive IgG titre occurred in at least 95% of the patients. In the control group results were similar. Conclusions: 1. Determination of IgG is not applicable to the diagnosis of food allergies and dietary modification in patients with IBS.

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Section: Discussionsupporting

confidence: 82%

Concentration of IgG antibodies against food allergens in patients with irritable bowel syndrome and healthy individuals

Traczyk¹,

M²,

Tomasiuk³

et al. 2011

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“…Th e primary role of B cells is to produce antibodies (Ig) directed against antigen, and IgG-positive B cells are increased in the blood of IBS patients relative to healthy subjects ( 68 ). Increased blood IgE and IgG concentrations are classically associated with allergy and are typically unaltered in IBS at baseline; however, in response to allergen serum IgE and IgG levels increase in IBS patients above that observed in health ( 37,70,71 ). Interestingly, increased levels of autoantibodies against neuronal channels have been observed in IBS patients; however, the clinical implications of this are yet to be determined ( 105,106 ).…”

Section: B Cellsmentioning

confidence: 99%

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

Hughes

Zola

et al. 2013

American Journal of Gastroenterology

132

117

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Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal (GI) tract characterized by pain or discomfort from the lower abdominal region, which is associated with altered bowel habit. Despite its prevalence, there is currently a lack of effective treatment options for patients. IBS has long been considered as a neurological condition resulting from alterations in the brain gut axis, but immunological alterations are increasingly reported in IBS patients, consistent with the hypothesis that there is a chronic, but low-grade, immune activation. Mediators released by immune cells act to either dampen or amplify the activity of GI nerves. Release of a number of these mediators correlates with symptoms of IBS, highlighting the importance of interactions between the immune and the nervous systems. Investigation of the role of microbiota in these interactions is in its early stages, but may provide many answers regarding the mechanisms underlying activation of the immune system in IBS. Identifying what the key changes in the GI immune system are in IBS and how these changes modulate viscerosensory nervous function is essential for the development of novel therapies for the underlying disorder.

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“…It is hypothesized that mucosal immune activation by FAs may contribute to the development of food allergy and IBS [9,11,13,[15][16][17]21,25] . Clinically, the role of food-intolerance-induced symptoms in IBS frequently contrasts with that in food allergy [20,[22][23][24][25]29,[37][38][39][40][41][42] , and dietary elimination may be associated with symptom improvement [31] . However, the interaction of food with the gastrointestinal system is not completely understood [13,17,20,22,23,25,29,[33][34][35][36][37]39] .…”

Section: Discussionmentioning

confidence: 99%

Discrepancies between the responses to skin prick test to food and respiratory antigens in two subtypes of patients with irritable bowel syndrome

Soares

Figueiredo²,

Santos³

et al. 2008

WJG

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FA responses differed significantly from those for the other two groups (P < 0.01). CONCLUSION:Despite the small number of cases studied, the higher reactivity to FAs in GroupⅠcompared to Groups Ⅱ and Ⅲ adds new information, and suggests the presence of a possible alteration in intestinal epithelial function. INTRODUCTIONIrritable bowel syndrome (IBS) is an extremely common disorder that affects about one in every 5-10 persons. Estimates of prevalence range from 9% to 22% depending upon population group studied [1][2][3][4][5][6][7] . The exact pathophysiology of IBS remains unknown, although various mechanisms including gastrointestinal dismotility and visceral hypersensitivity have been well studied in IBS [8][9][10] . Recent interest has also been directed to the possible participation of the mucosa in the pathophysiology of IBS [11][12][13] . Inflammatory mediators cause intestinal dysfunction and a consequent increase in permeability [14][15][16][17] . However the role and interaction of inflammatory mediators with IBS remains to be determined [17] . IBS is defined by symptomatic criteria rather than biological markers.

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Food-Specific Serum IgG4 and IgE Titers to Common Food Antigens in Irritable Bowel Syndrome

Abstract: Serum IgG4 antibodies to common foods like wheat, beef, pork, and lamb are elevated in IBS patients. In keeping with the observation in other atopic conditions, this finding suggests the possibility of a similar pathophysiological role for IgG4 antibodies in IBS.

Cited by 106 publications

References 26 publications

Concentration of IgG antibodies against food allergens in patients with irritable bowel syndrome and healthy individuals

Concentration of IgG antibodies against food allergens in patients with irritable bowel syndrome and healthy individuals

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

Discrepancies between the responses to skin prick test to food and respiratory antigens in two subtypes of patients with irritable bowel syndrome

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