Discrepancies between the responses to skin prick test to food and respiratory antigens in two subtypes of patients with irritable bowel syndrome

Abstract

FA responses differed significantly from those for the other two groups (P < 0.01). CONCLUSION:Despite the small number of cases studied, the higher reactivity to FAs in GroupⅠcompared to Groups Ⅱ and Ⅲ adds new information, and suggests the presence of a possible alteration in intestinal epithelial function. INTRODUCTIONIrritable bowel syndrome (IBS) is an extremely common disorder that affects about one in every 5-10 persons. Estimates of prevalence range from 9% to 22% depending upon population group studied [1][2][3][4][5][6][7] . The exact pathophysiology of IBS remains unknown, although various mechanisms including gastrointestinal dismotility and visceral hypersensitivity have been well studied in IBS [8][9][10] . Recent interest has also been directed to the possible participation of the mucosa in the pathophysiology of IBS [11][12][13] . Inflammatory mediators cause intestinal dysfunction and a consequent increase in permeability [14][15][16][17] . However the role and interaction of inflammatory mediators with IBS remains to be determined [17] . IBS is defined by symptomatic criteria rather than biological markers.

Allergy‐related diseases and recurrent abdominal pain during childhood – a birth cohort study

“…Earlier adult studies have found an increased occurrence of self reported food hypersensitivity among individuals with IBS compared to individuals without IBS, which is consistent with our findings. Moreover, we found that children sensitised to food allergens had an increased risk of AP, whereas previous adult studies have found both positive and no risk increase. Sensitisation to airborne allergens was not associated with an increased risk of AP, which is consistent with a previous adult study …”

“…Moreover, we found that children sensitised to food allergens had an increased risk of AP, whereas previous adult studies have found both positive and no risk increase. Sensitisation to airborne allergens was not associated with an increased risk of AP, which is consistent with a previous adult study …”

The prevalence and clinical characteristics of atopic manifestations in patients with irritable bowel syndrome in a Brazilian urban community

“…30 The report of a significant correlation among atopy and increased intestinal permeability suggests that the immune system may play a role in IBS pathogenesis of at least a subpopulation of IBS patients. [30][31][32][33] In the current study, we didn't find a significant association between personal history of allergies and IBS clinical sub-type, but the present results confirm the association between allergy and IBS. 23 Twenty-nine volunteers with IBS reported intolerance to multiple foods that caused abdominal cramping, but the food intolerance was not specifically associated with IBS crises in any of them.…”

Effect ofLactobacillus plantarum299v treatment in an animal model of irritable bowel syndrome

“…According to the widely accepted Rome III criteria, the disease is defined as a 12-week period within 12 months in which the patient experiences lower abdominal pain that involves a change in stool consistency and frequency that can be relieved by defecation. Characterized by bloating, cramps, and changes in bowel habits, IBS is commonly found in three forms: IBS-D (diarrhea dominant), IBS-C (constipation dominant), and IBS-A (alternating stool pattern) (2). The cause of IBS remains obscure, although a disturbed gastrointestinal (GI) motor function and a visceral hypersensitivity have become core features.…”