Food safety assurance using methods of chemical analysis

Амелин, В. Г.; Лаврухина, О. И.

doi:10.1134/s1061934817010038

Cited by 20 publications

(11 citation statements)

References 358 publications

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“…The key point of this method is sample extraction by water acetonitrile or ethylacetate in the presence of the salting-out complex, purification by the method of disperse SPE and chromatographic analysis. Recently this method has been used to simultaneously determine not only residual pesticide content, but veterinary products, natural toxins in the food raw material with minimal costs due to application of various QuEChERS modifications at the stage of sample preparation [39,43] . In this method MeCN is used in the presence of buffering salts (sodium citrate) for component extraction.…”

Section: Quechers Methodsmentioning

confidence: 99%

Acetonitrile as tops solvent for liquid chromatography and extraction

Рудаков

Rudakova

Селеменев

2018

JACS

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This article deals with acetonitrile physico-chemical properties and its mixtures with water. It covers the information about isotherms of such parameters of the acetonitrile-water binary system as density, viscosity, permeation coefficient, refraction index, optic density, a boiling point isobar. Authors suggest a generalized criterion of acetonitrile polarity. The article also discusses means of polarity assessment and eluotropic strength of mobile phases on the basis of acetonitrile mixtures with water with application of generalized criteria. Special attention is paid to the options of acetonitrile application in various extraction methods of chromatographic sample preparation. The article also reveals advantages and problems of acetonitrile application as a mobile phase modifying agent in the HPLC reversed-phase and as a hydrophilic extra-agent in liquid-liquid extraction.

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Section: Quechers Methodsmentioning

confidence: 99%

Acetonitrile as tops solvent for liquid chromatography and extraction

Рудаков

Rudakova

Селеменев

2018

JACS

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“…Суть метода состоит в экстракции пробы водным MeCN или этилацетатом в присут-ствии высаливающего комплекса, очистке методом дисперсионной ТФЭ и хромато-графическом анализе. В последнее время этим методом одновременно определяют не только остаточные содержания пестицидов, но и ветеринарных препаратов, при-родных токсинов в пищевом сырье с минимальными затратами, благодаря использо-ванию на стадии пробоподготовки различных модификаций QuEChERS [40,44]. В этом методе для экстракции компонентов используют MeCN в присутствии буфери-рующих солей (цитратов натрия).…”

Section: экстракционные свойства ацетонитрила и его смесей с водойunclassified

“…Для очистки экстрактов от липидов, жиров и бел-ков применяют насыпные сорбенты Bondesil-PSA, C18, графитированную сажу, ио-нообменные смолы и их комбинации. К современным достижениям в области разви-тия QuEChERS для пробоподготовки комплексных матриц можно отнести дополни-тельную очистку экстрактов методом дисперсионной микро-ЖЖЭ, суть которой за-ключается в быстром впрыскивании в воду ацетонитрильного экстракта QuEChERS с добавленным в него органическим растворителем, не смешивающимся с водой [44]. В результате образуется эмульсия, что вследствие увеличения поверхности со-прикосновения фаз повышает эффективность разделения компонентов.…”

Section: экстракционные свойства ацетонитрила и его смесей с водойunclassified

“…После цен-трифугирования для анализа используют выделившуюся органическую фазу. Благо-даря этой простой в исполнении дополнительной стадии, требующей значительно меньших количеств органических растворителей по сравнению с классическими ме-тодами экстракции, возможно одновременное селективное хроматографическое оп-ределение множества компонентов пробы, включая пестициды, ветпрепараты, сти-муляторы роста (соединения с эстрогенной активностью) и микотоксины [44].…”

Section: экстракционные свойства ацетонитрила и его смесей с водойunclassified

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Хроматографические И Экстракционные Свойства Ацетонитрила И Его Смесей С Водой

Рудаков¹,

Селеменев²,

Rudakova³

et al. 2018

sorpchrom

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В обзоре рассмотрены хроматографические и экстракционные свойства ацетонитрила и его смесей с водой. Обсуждено влияние состава смесей ацетонитрил -вода на такие свойства как плот-ность, вязкость, коэффициент проницаемости, показатель преломления, оптическая плотность, темпе-ратура кипения. Рассмотрено применение обобщенного критерия полярности ацетонитрила в оценке элюирующей способности подвижных фаз на основе смесей ацетонитрила с водой. Показаны пре-имущества и проблемы применения ацетонитрила как модификатора подвижной фазы в обращен-но-фазовой ВЭЖХ и как гидрофильного экстрагента в жидкостно-жидкостной экстракции. In 2018 the scientific community celebrates 115 years of discovery of the liquid chromatography method by M.S. Tsvet, and also 50 years since the development of the high-performance liquid chromatography method. The key component of the chromatographic sorbent-sorbate-eluent system, whose optimization is devoted to the authors' studies of the article, is the eluent. High-performance liquid chromatography has become an important method of analysis over the past decades. Acetonitrile is a unique solvent for chromatography. It is used as the main component for water-organic mobile phases in reversed-phase and hydrophilic HPLC. The review discusses the features of its physicochemical properties which should be taken into account in analytical practice. Effective methods of sample preparation are required for the analysis of biologically active substances in different matrices using HPLC. Methods of liquid-liquid extraction (LLE) of analytes from aqueous solutions with salting out and drying out; micro-LLE; dispersive micro-LLE, lowtemperature LLE, extraction by freezing, combined sorption-extraction method QuEChERS are considered. Acetonitrile is used for each of these sample preparation methods. The review discusses the effect of the composition of acetonitrile-water mixtures on such properties as density, viscosity, permeability coefficient, refractive index, optical density, boiling point. The relative polarity, eluting and solubilizing ability of aceto-

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“…The use of QuEChERS instead of SPE (solid phase extraction) was chosen because it showed good applicability to extract RAC from muscle, feed, and MBM matrices [14,15,23,24]. The QuEChERS method was originally developed for pesticides extraction [25], although other compounds such as pharmaceuticals, mycotoxins, β-agonists and polycyclic aromatic hydrocarbons have also been extracted by this method in a wide variety of complex matrices [26][27][28]. Therefore, QuEChERS extraction method needs to be adapted to different analytes or matrices.…”

Section: Extraction Methods and Lc-ms/ms Analysismentioning

confidence: 99%

Ractopamine: analytical method validation; and the detection in loin, tissues and urine of pigs fed meat and bone meal containing this growth promoter

Aroeira¹

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Ractopamine: analytical method validation; and the detection in loin, tissues and urine of pigs fed meat and bone meal containing this growth promoter Ractopamine hydrochloride (RAC) is a β-agonist additive that has been used in many countries as a repartitioning agent, redirecting nutrients in order to increase leanness and decrease lipid deposition in pigs. Countries from the European Union and Asia question their safety, while American countries and Australia allow their controlled use as an additive added to the feed of pigsin the finishing phase. In Brazil, the Ministry of Agriculture, Livestock and Food Supply together with the national production sector, developed a Program called "SplitSystem" to ensure a safe product without RAC in order to meet international sanitary requirements. However, coproducts used in animal feed may contain RAC, such as meat and bone meal (MBM), one of the main feed ingredients used in many countries which can partially replace soybean meal to lower costs. As the level of RAC in this protein source has not been established an experiment was under taken to examine the impact on pig tissues of increasing amounts of meat and bone meal (MBM) in four dietary groups: 0, 7, 14 and 21% w/w of MBM-containing RAC (53.5 µg kg-1) in the diet. The purpose was to verify if ractopamine residues remain in pig tissues (muscle, liver, kidneys, and lungs) and how much is eliminated through urine. To addrress these concerns, gilts were fed RAC via MBM daily, from weaning until slaughter. RAC was determined in muscle, liver, kidneys, and lungs with a limit of detection (LOD) = 0.15, 0.5, 0.5 and 1.0 µg kg-1 , respectively), and no RAC residues were quantified above the limit of quantification (LOQ) = 0.5, 2.5, 2.5 and 2.5 µg kg-1 , respectively). In urine, RAC concentration remained below 1.35 µg L-1. These values are below the maximum residue limits (MRLs) established by legislation. Therefore, MBM (53.5 μg kg-1 of RAC) can be used up to 21% in pig diets, however when considering restrictive markets, it is recommended not to use MBM.

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Food safety assurance using methods of chemical analysis

Cited by 20 publications

References 358 publications

Acetonitrile as tops solvent for liquid chromatography and extraction

Acetonitrile as tops solvent for liquid chromatography and extraction

Хроматографические И Экстракционные Свойства Ацетонитрила И Его Смесей С Водой

Ractopamine: analytical method validation; and the detection in loin, tissues and urine of pigs fed meat and bone meal containing this growth promoter

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