Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa

Holsen, Laura M.; Lawson, Elizabeth A.; Blum, Justine; Ko, Eunice; Makris, Nikos; Fazeli, Pouneh K.; Klibanski, Anne; Goldstein, Jill M.

doi:10.1503/jpn.110156

Cited by 134 publications

(173 citation statements)

References 62 publications

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…42,43 A relatively large number of neuroimaging studies in patients with anorexia nervosa have reported group differ ences in this brain region (Appendix 1, Table S9). Most of these studies tested cue reactivity to visual or actual food stimuli and reported either insula hypo 8,9,44,45 or hyperactiv ity 6,44,46 in patients with anorexia nervosa compared with con trols. Studies investigating body image processing have yielded equally heterogeneous results with either reduced 47 or increased 48,49 insula responses to self images in patients with anorexia nervosa.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the clinical presentation, several functional neuroimaging studies have focused on the processing of food/taste and other appe titive stimuli. [4][5][6][7][8][9] Results suggest that patients may have an al tered sensitivity for sensory interoceptive and/or reward processes as well as an impaired awareness of homeostatic needs. 10 However, published reports revealed considerable inconsistencies, which may be explained by substantial vari ability among studies, including issues with task design, stimulus selection and varying cognitive abilities of the starv ing participants.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa

Geisler

Borchardt

Lord

et al. 2016

jpn

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa

Geisler

Borchardt

Lord

et al. 2016

jpn

View full text Add to dashboard Cite

“…Interestingly, the opposite pattern is observed in anorexia nervosa patients. In these patients, the amygdala is hypoactive when patients are presented with high-calorie foods, independently of whether these patients were currently underweight or weight-restored [63].…”

Section: Amygdala and Cue-induced Feedingmentioning

confidence: 94%

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Coppin

2016

Physiology & Behavior

View full text Add to dashboard Cite

• The amygdala and hippocampus play a major role in food intake and weight regulation.• These functions are far less known to cognitive and affective scientists.• This review uniquely expands on the interactions between these two brain structures. a b s t r a c t a r t i c l e i n f o The anterior medial temporal lobes are one of the most studied parts of the brain. Classically, their two main structures -the amygdalae and the hippocampi -have been linked to key cognitive and affective functions, related in particular to learning and memory. Based on abundant evidence, we will argue for an alternative but complementary point of view: they may also play a major role in food intake and body weight regulation. First, an overview is given of early clinical evidence in this line of thought. Subsequently, empirical evidence is presented on how food intake, including in the extreme case of obesity, may relate to amygdalian and hippocampal functioning. The focus is on the amygdala's role in processing the relevance of food stimuli, cue-induced feeding, and stress-induced eating and on the hippocampus' involvement in the use of interoceptive signals of hunger and satiety, as well as memory and inhibitory processes related to food intake. Additionally, an elaboration takes place on possible reciprocal links between food intake, body weight, and amygdala and hippocampus functioning. Finally, issues that seemed particularly critical for future research in the field are discussed.

show abstract

“…CRH system is a mediator of the appetitesuppressing effects of stress also in fish (Bernier, 2006). Other brain areas, like amygdala (Holsen et al, 2012;Solomon et al, 2010), dorsal vagal complex (Charrier et al, 2006) and dorsal raphe (Holsen et al, 2012), may contribute to stress-induced anorexia without affecting the HPA axis activity.…”

Section: Stress-induced Anorexiamentioning

confidence: 99%

Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis

Бажан¹,

Zelena²

2013

Brain Research Bulletin

View full text Add to dashboard Cite

a b s t r a c tThe prevalence of obesity is increasing worldwide with serious consequences such as diabetes mellitus type 2 and cardiovascular diseases. Emotional stress is considered to be one of the main reasons of obesity development in humans. However, there are some contradictory results, which should be addressed. First of all stress induces anorexia, but not overeating in laboratory animals. Glucocorticoids, the effector molecules of the hypothalamo-pituitary-adrenocortical (HPA) axis stimulate and stress inhibits food intake. It is also not clear if stress is diabetogenic or an antidiabetogenic factor. The review will discusses these issues and the involvement of the whole HPA axis and its separate molecules (glucocorticoids, adrenocorticotropin, corticotropin-releasing hormone) in food intake regulation under stress.

show abstract

Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa

Cited by 134 publications

References 62 publications

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis

Contact Info

Product

Resources

About