Food-Induced Acute Pancreatitis

Manohar, Murli; Verma, Alok; Venkateshaiah, Sathisha Upparahalli; Goyal, Hemant; Mishra, Anil

doi:10.1007/s10620-017-4817-2

Cited by 20 publications

(17 citation statements)

References 73 publications

(122 reference statements)

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“…Acute pancreatitis in patients with immediate FA, however, has occasionally been reported. 8,9 This study has shown that pancreatic dysfunction is not a rare complication of immediate FA because an increase in serum amylase was observed in one-third of OFC-positive patients after OFC.…”

Section: Discussionmentioning

confidence: 84%

“…Acute pancreatitis due to immediate FA has been sporadically reported . In some cases, pancreatitis developed after oral food challenge (OFC) .…”

mentioning

confidence: 99%

“…Acute pancreatitis due to immediate FA has been sporadically reported. 8 In some cases, pancreatitis developed after oral food challenge (OFC). 9 Although harmful effects of OFC on the pancreas have not yet been recognized, clinicians should pay attention to laboratory data in patients with immediate FA to prevent serious complications.…”

mentioning

confidence: 99%

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Neutrophilia and hyperamylasemia in patients with immediate food allergy

Kimura

Ito

Shimomura

et al. 2019

Pediatrics International

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BackgroundPresently, little is known about the laboratory data several hours after oral food challenge (OFC) in patients with immunoglobulin (Ig)E‐mediated immediate food allergy (FA).MethodsOne hundred and twelve subjects who underwent OFC at the present institute between 1 June 2016 and 31 March 2018, were enrolled in this study. Changes in laboratory data several hours after OFC were examined.Results OFC was positive in 76 patients and negative in 36. Increase in absolute neutrophil count (ANC) was significantly higher in OFC‐positive than in OFC‐negative subjects (median, 2,306/μL vs 637/μL; P < 0.00001). On multivariate regression analysis, a significant correlation was seen between neutrophilia and the development of gastrointestinal symptoms (t = 3.63; P < 0.001). Serum interleukin‐6 increased in 43.8% of the patients with marked neutrophilia and had a significant positive correlation with ANC (r = 0.64; P < 0.001). Serum amylase increased in 33.3% of the OFC‐positive patients and was >100 U/L (median, 642 U/L) in five patients in whom serum lipase also increased markedly (1,197 U/L). There was a significant negative correlation between increase in serum amylase and decrease in absolute eosinophil count (r = −0.36, P < 0.01).ConclusionsMarked neutrophilia was seen after OFC in patients with immediate FA presenting gastrointestinal symptoms, which may provide an insight into the relationship between symptoms and laboratory data. A considerable increase in serum amylase after OFC was also seen in patients with immediate FA, suggesting that the pancreas is a target organ for immediate FA.

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Section: Discussionmentioning

confidence: 84%

“…Acute pancreatitis due to immediate FA has been sporadically reported . In some cases, pancreatitis developed after oral food challenge (OFC) .…”

mentioning

confidence: 99%

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Neutrophilia and hyperamylasemia in patients with immediate food allergy

Kimura

Ito

Shimomura

et al. 2019

Pediatrics International

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“…Pancreatitis is a disease defined as an acute or chronic inflammatory process of the pancreas and characterised by the induced pro-inflammatory cytokines, chemokines and tissue recruitment of inflammatory cells, including monocytes, macrophages, and eosinophils [1][2][3][4][5]. Eosinophils are immune cells, and they play a key role in the mucosal immune system of the gastrointestinal tract during normal and inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic pancreatitis: a rare or unexplored disease entity?

Manohar

Verma

Singh

et al. 2020

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Several case reports show accumulation of eosinophils in pancreatitis patients and term the disease as "eosinophilic pancreatitis (EP)". EP usually presents with a pancreatic tumour and abdominal pain in obstructive jaundice, which is generally not diagnosed until the patient undergoes pancreatic resection. Histologically, EP reveals distinct patterns like diffused, periductal, acinar, and septal inflammatory infiltrates with eosinophils, eosinophilic phlebitis, and localised extreme eosinophilic infiltrates related with pseudocyst formation. EP patients also have elevated serum IgE levels with high eosinophil counts in the pancreas as well as in other organs such as the gastrointestinal tract, which is termed as eosinophilic gastroenteritis. Due to the lack of knowledge based on just a few case reports, it is considered that eosinophilic infiltration is quite rare in the pancreas; therefore, the significance of eosinophils in pancreatitis is not yet established. This review assesses the current understanding of eosinophilic pancreatitis and the important role of eosinophils in promoting pancreatic fibrosis including malignancy.

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“…The presence of many hypotheses of the development of acute pancreatitis such as duct hypertension, pancreatic reflux, vascular, allergic, neuro-reflex, infectious, journal homepage: https://morphology-journal.com Vol. 24, №1, Page 34-38 negative consequences [13,14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Bouginage and Washing of the Pancreatic Duct on the Course of Experimental Acute Pancreatitis

Kostyuk

Бурков

et al. 2018

Rep. of Morph.

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The presence of many hypotheses of the development of acute pancreatitis such as pancreatic duct hypertension, pancreatic reflux, vascular, allergic, neuro-reflex, infectious, etc. confirm the lack of a clear understanding of the development mechanisms of this pathology, and hence inaccuracy in the treatment and negative consequences. The purpose of this study was to investigate the effect of bouginage and flushing of the pancreatic duct on the course of experimental acute pancreatitis. Experiments were carried out on 12 dogs, for which a model of pancreatitis was created by autobile administration into the pancreas duct. Animals were divided into four groups, 3 animals per each, with the term of deduce from the test in one, three, seven days and six months respectively. Before the pancreas duct perfusion, it was injected with polyvinylchloride bougie that was removed through the incision in the distal part of the pancreas duct. Such manipulation allowed to conduct duct washing with medicinal substances at a pressure of 0.49-0.6 kPa and confirmed the assumption that in acute pancreatitis, filling of pancreas duct with condensed protein masses was observed, and this, changes the approach not only to the establishment of the pathogenetic link in the process of acute pancreatitis development, but also to its treatment. The duct was washed once. The common comprehensive drug therapy was carried out in dogs within the next five, six days. At the end of the first day, out of the 12 dogs, nine stood independently, the rest - on the second day. On the third day, all animals drank water, responded to stimuli. On the fifth day they were active, taking liquid feed. On the seventh day on their behavior and feeding manner the dogs of this group did not differ from healthy ones. To study morphological changes in pancreas after duct washing, three dogs were withdrawn from the test in one day. At autopsy effusion in peritoneal cavity was not observed. The left lobe of pancreas was a little bit shorter. Place of dissection of the tissues of the pancreas and the duct is covered with a blood clot. In the area of duodenum dissection, isolated patches of steatoenecrosis retained. Microscopically, in the duct area dissection changes in pancreas tissues, in general, were the same as in duct dissection without perfusion. At the same time, the plethora for this term was great. Necrotic centers of parenchyma were isolated and with moderate neutrophilic infiltration. Distant from the dissection zone in pancreas tissues there were minor focal hemorrhages with a violation of its structure, however, hyperplasia, foci of neutrophilic infiltration of the interstitial connective tissue were less manifestated. In the proximal part of the duct, the pancreas tissue retained moderate plethora. In addition, there were small foci of hemorrhages with a violation of the structure of individual acinus and slight neutrophilic infiltration in interstitial connective tissue. The latter was also marked by the accumulation of macrophages and the proliferation of fibroblasts, there were isolated areas of hemorrhages. In intact part there was an insignificant edema of interstitial connective tissue. As a result of the conducted experiments, we were convinced of the effectiveness of this method of treating acute pancreatitis.

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Food-Induced Acute Pancreatitis

Cited by 20 publications

References 73 publications

Neutrophilia and hyperamylasemia in patients with immediate food allergy

Neutrophilia and hyperamylasemia in patients with immediate food allergy

Eosinophilic pancreatitis: a rare or unexplored disease entity?

Effect of Bouginage and Washing of the Pancreatic Duct on the Course of Experimental Acute Pancreatitis

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