Neutrophilia and hyperamylasemia in patients with immediate food allergy

Abstract

BackgroundPresently, little is known about the laboratory data several hours after oral food challenge (OFC) in patients with immunoglobulin (Ig)E‐mediated immediate food allergy (FA).MethodsOne hundred and twelve subjects who underwent OFC at the present institute between 1 June 2016 and 31 March 2018, were enrolled in this study. Changes in laboratory data several hours after OFC were examined.Results OFC was positive in 76 patients and negative in 36. Increase in absolute neutrophil count (ANC) was significantly higher in OFC‐positive than in OFC‐negative subjects (median, 2,306/μL vs 637/μL; P < 0.00001). On multivariate regression analysis, a significant correlation was seen between neutrophilia and the development of gastrointestinal symptoms (t = 3.63; P < 0.001). Serum interleukin‐6 increased in 43.8% of the patients with marked neutrophilia and had a significant positive correlation with ANC (r = 0.64; P < 0.001). Serum amylase increased in 33.3% of the OFC‐positive patients and was >100 U/L (median, 642 U/L) in five patients in whom serum lipase also increased markedly (1,197 U/L). There was a significant negative correlation between increase in serum amylase and decrease in absolute eosinophil count (r = −0.36, P < 0.01).ConclusionsMarked neutrophilia was seen after OFC in patients with immediate FA presenting gastrointestinal symptoms, which may provide an insight into the relationship between symptoms and laboratory data. A considerable increase in serum amylase after OFC was also seen in patients with immediate FA, suggesting that the pancreas is a target organ for immediate FA.

Incidence and risk factors of postoperative hyperamylasemia and pancreatitis following total knee arthroplasty: a retrospective study

“…However, no signi cant difference was found between hyperamylasemia and normal groups in AMC, monocyte percentage and serum creatinine preoperatively or postoperatively in this study. Additionally, previous studies [29,30]reported that hyperamylasemia was associated with the peripheral blood eosinophil level. Kimura et.al [30]found that there was a signi cant negative correlation between increase in serum amylase and decrease in AEC in oral food challenge-positive patients with immediate food allergy.…”

“…Additionally, previous studies [29,30]reported that hyperamylasemia was associated with the peripheral blood eosinophil level. Kimura et.al [30]found that there was a signi cant negative correlation between increase in serum amylase and decrease in AEC in oral food challenge-positive patients with immediate food allergy. Weir et.al.…”

Incidence and risk factors of postoperative hyperamylasemia and pancreatitis following total knee arthroplasty: a retrospective study

“…However, no significant difference was found between hyperamylasemia and normal groups in AMC, monocyte percentage and serum creatinine preoperatively or postoperatively in this study. Additionally, previous studies [ 31 , 32 ]reported that hyperamylasemia was associated with the peripheral blood eosinophil level. Kimura et al [ 32 ] found that there was a significant negative correlation between increase in serum amylase and decrease in AEC in oral food challenge-positive patients with immediate food allergy.…”

Secrets, puzzles and mysteries of macroamylasemia

“…Значимое повышение уровня амилазы в крови происходит при пищевой аллергии. К такому выводу пришли японские исследователи, исследовав содержание амилазы в крови пациентов, страдавших IgE-опосредованной пищевой аллергией немедленного типа (n=120), после проведения перорального провокационного теста [29]. В подгруппе больных с положительными результатами провокационного теста у 33,3% пациентов зафиксировали значимое повышение уровня амилазы >100 Ед/л (медиана -642 Ед/л).…”

“…В 5 случаях рост уровня амилазы крови сопровождался увеличением сывороточной концентрации липазы. Получив такие данные, М. Kimura et al предположили, что обнаружение МАЕ при пищевой аллергии может свидетельствовать о вовлечении ПЖ в патологический процесс: «ПЖ является органом-мишенью при пищевой аллергии немедленного типа» [29].…”