Food deprivation enhances both autoshaping and autoshaping impairment by a latent inhibition procedure

Sparber, Sheldon B.; Bollweg, George; Messing, Rita B.

doi:10.1016/0376-6357(91)90106-a

Cited by 14 publications

(5 citation statements)

References 27 publications

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“…The level of food restriction is also positively related to the rate of autoshaping with a food reinforcer (Sparber et al 1991). The present results extend previous findings to show that increasing the degree of food restriction accelerates the rate of acquisition of IV cocaine-reinforced behavior.…”

Section: Discussionsupporting

confidence: 83%

Dietary additives and the acquisition of cocaine self-administration in rats

Carroll

Sylvie

1998

Psychopharmacology

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The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedule. One group had ad libitum access to caffeine- (0.2% w/w) admixed food. Three groups had access to 10 g, 20 g or ad lib food each day. Another three groups had the same three amounts of ground food with powdered saccharin (0.2% w/w) added. During daily 6-h autoshaping sessions, ten infusions were delivered each hour under a random-time 90-s schedule after a brief (15 s) extension of a retractable lever. These were followed by 6-h self-administration sessions, when the lever remained extended and cocaine infusions were available under an FR 1 schedule. The acquisition criterion was self-administration of a mean of 100 infusions over 5 days. Cocaine self-administration was accelerated in the caffeine group compared to the regular chow group. However, by 30 days nearly the same percentage of rats in the caffeine and regular food groups met the acquisition criterion. In the other six groups, as the amount of food increased, the rate of acquisition and percentage of rats per group meeting the acquisition criterion decreased. In the ad lib group, acquisition was further reduced when saccharin was added to food. In summary, dietary caffeine accelerated acquisition and a greater amount and increased palatability of food independently interfered with acquisition of cocaine self-administration in rats.

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Section: Discussionsupporting

confidence: 83%

Dietary additives and the acquisition of cocaine self-administration in rats

Carroll

Sylvie

1998

Psychopharmacology

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“…Using this procedure, rate of acquisition can be controlled by varying the delay between lever retraction and reinforcer delivery. For example, when food was used as a reinforcer, Messing et al (1986) showed that the acquisition of a lever pressing response occurred at a slower rate as the delay between lever retraction and food pellet delivery was increased from 2 to 4 to 8 s. Furthermore, rate of acquisition has been found to decrease as the level of food restriction increases (Sparber et al 1991). In the present experiment, a short delay was used between lever retraction and delivery of a cocaine infusion or a food pellet (1 s).…”

Section: Discussionmentioning

confidence: 94%

Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats

Campbell

Carroll

2001

Psychopharmacology

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“…Acquisition of AMPH self‐administration was initiated using an autoshaping procedure similar to that described previously (Carroll & Lac 1993). Three days prior to autoshaping, animals were restricted to 20 g food per day to enhance motivation for drug (Sparber et al 1991). For 5 consecutive days, rats were given a 60‐minute autoshaping session, followed 30 minutes later by a 60‐minute contingent AMPH self‐administration session.…”

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confidence: 99%

Genetics of novelty seeking, amphetamine self‐administration and reinstatement using inbred rats

Meyer

Rahman

Charnigo

et al. 2010

Genes Brain and Behavior

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Previous research using outbred rats indicates that individual differences in activity in a novel environment predict sensitivity to the reinforcing effect of psychostimulant drugs. The current study examined if the link between responses related to novelty and amphetamine self-administration is heritable. Twelve inbred rat strains were assessed for locomotor activity in a novel environment, preference for a novel environment, and intravenous amphetamine self-administration (acquisition, extinction and amphetamine-induced reinstatement). Strain differences were observed in activity in a novel environment, novelty preference and amphetamine selfadministration, indicating a genetic influence for each of these behaviors. While there was no relation between activity in an inescapable novel environment and amphetamine self-administration, strain-dependent differences in novelty preference were positively correlated with the amount of amphetamine self-administered. There was also a positive correlation between the dosedependent rate of amphetamine self-administration and magnitude of reinstatement. These results show that the activity in an inescapable novel environment and the preference for a novel environment are different genetically, and thus likely to reflect different behavioral constructs. Moreover, these results implicate a genetic influence on the relation between novelty seeking and stimulant self-administration, as well as on the relation between stimulant reward and reinstatement.

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Food deprivation enhances both autoshaping and autoshaping impairment by a latent inhibition procedure

Cited by 14 publications

References 27 publications

Dietary additives and the acquisition of cocaine self-administration in rats

Dietary additives and the acquisition of cocaine self-administration in rats

Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats

Genetics of novelty seeking, amphetamine self‐administration and reinstatement using inbred rats

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