Food anthocyanins decrease concentrations of TNF-α in older adults with mild cognitive impairment: A randomized, controlled, double blind clinical trial

Rosario, Vinicius A. do; Fitzgerald, Zoë; Broyd, Samantha J.; Paterson, Amelia; Roodenrys, Steven; Thomas, Susan J.; Bliokas, Vida; Potter, Jan; Walton, Karen; Weston–Green, Katrina; Yousefi, Maziar; Williams, David M.; Wright, Ian; Charlton, Karen E

doi:10.1016/j.numecd.2020.11.024

Cited by 26 publications

(33 citation statements)

References 54 publications

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“…Although the identification and classification of MCI are considered to be a significant challenge, the diagnosis of this condition comprises neuroimaging, clinical assessments, and a neurophysiological evaluation. No medications are considered effective in combating dementia, mainly because MCI patients are only steps away from having dementia [105][106][107].…”

Section: Ginkgo Biloba and Mild Cognitive Impairmentmentioning

confidence: 99%

Ginkgo biloba in the Aging Process: A Narrative Review

et al. 2022

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Neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other degenerative processes commonly appear with aging. Ginkgo biloba (GB) is associated with several health benefits, including memory and cognitive improvement, in Alzheimer’s disease (AD), Parkinson’s disease (PD), and cancer. Its antiapoptotic, antioxidant, and anti-inflammatory actions have effects on cognition and other conditions associated with aging-related processes, such as insulin resistance, hypertension, and cardiovascular conditions. The aim of this study was to perform a narrative review of the effects of GB in some age-related conditions, such as neurodegenerative diseases, CVD, and cancer. PubMed, Cochrane, and Embase databases were searched, and the PRISMA guidelines were applied. Fourteen clinical trials were selected; the studies showed that GB can improve memory, cognition, memory scores, psychopathology, and the quality of life of patients. Moreover, it can improve cerebral blood flow supply, executive function, attention/concentration, non-verbal memory, and mood, and decrease stress, fasting serum glucose, glycated hemoglobin, insulin levels, body mass index, waist circumference, biomarkers of oxidative stress, the stability and progression of atherosclerotic plaques, and inflammation. Therefore, it is possible to conclude that the use of GB can provide benefits in the prevention and treatment of aging-related conditions.

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Section: Ginkgo Biloba and Mild Cognitive Impairmentmentioning

confidence: 99%

Ginkgo biloba in the Aging Process: A Narrative Review

et al. 2022

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“…Although it is true that the effect of this nutraceutical on depression has not been investigated, the clinical trial carried out on elderly adults with cognitive disorders, who ingested juice with a high content of anthocyanins (201 mg) for 8 weeks, obtained a reduction in serum TNF-α compared to the other groups, which may be indicative of cognitive improvement [ 299 ]. Another study supports this statement, since the magnetic resonance imaging tests reflected the increase in brain activity related to increased perfusion in regions responsible for this task [ 300 ].…”

Section: Nutritional Intervention In Women With Mddmentioning

confidence: 99%

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

et al. 2022

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Major depressive disorder (MDD) is an incapacitating condition characterized by loss of interest, anhedonia and low mood, which affects almost 4% of people worldwide. With rising prevalence, it is considered a public health issue that affects economic productivity and heavily increases health costs alone or as a comorbidity for other pandemic non-communicable diseases (such as obesity, cardiovascular disease, diabetes, inflammatory bowel diseases, etc.). What is even more noteworthy is the double number of women suffering from MDD compared to men. In fact, this sex-related ratio has been contemplated since men and women have different sexual hormone oscillations, where women meet significant changes depending on the age range and moment of life (menstruation, premenstruation, pregnancy, postpartum, menopause…), which seem to be associated with susceptibility to depressive symptoms. For instance, a decreased estrogen level promotes decreased activation of serotonin transporters. Nevertheless, sexual hormones are not the only triggers that alter neurotransmission of monoamines and other neuropeptides. Actually, different dietary habits and/or nutritional requirements for specific moments of life severely affect MDD pathophysiology in women. In this context, the present review aims to descriptively collect information regarding the role of malnutrition in MDD onset and course, focusing on female patient and especially macro- and micronutrient deficiencies (amino acids, ω3 polyunsaturated fatty acids (ω3 PUFAs), folate, vitamin B12, vitamin D, minerals…), besides providing evidence for future nutritional intervention programs with a sex-gender perspective that hopefully improves mental health and quality of life in women.

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“…The main characteristic of the 15 studies included in the review are summarized in Table 1 [56][57][58][59][60][61] and Table 2 [62][63][64][65][66][67][68][69][70]. Specifically, Table 1 reports the results of acute interventions (n = 6), and Table 2 reports the results related to the chronic dietary interventions (n = 9).…”

Section: Study Characteristicsmentioning

confidence: 99%

Plant-Based Foods and Vascular Function: A Systematic Review of Dietary Intervention Trials in Older Subjects and Hypothesized Mechanisms of Action

et al. 2022

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Cardiovascular diseases, still the leading cause of mortality in the world, are closely related to vascular function. Older subjects are more susceptible to endothelial dysfunction and therefore it is important to define possible preventive or support strategies, such as consumption of foods with health-promoting effects. This systematic review aims to summarize the currently available evidence on acute or chronic trials testing the effect of selected plant-based foods on vascular function parameters in older subjects, and consider plausible mechanisms that may support the main findings. A total of 15 trials were included and analyzed, testing the effects of beetroot, plum, blueberry, and vegetable oils. We found some interesting results regarding markers of vascular reactivity, in particular for beetroot, while no effects were found for markers of arterial stiffness. The amelioration of vascular function seems to be more related to the restoration of a condition of nitric oxide impairment, exacerbated by diseases or hypoxic condition, rather than the enhancement of a physiological situation, as indicated by the limited effects on healthy older subjects or in control groups with young subjects. However, the overall set of selected studies is, in any case, rather limited and heterogeneous in terms of characteristics of the studies, indicating the need for additional high-quality intervention trials to better clarify the role of vegetable foods in restoring and/or improving vascular function in order to better elucidate the mechanisms through which these foods may exert their vascular health benefits in older subjects.

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Food anthocyanins decrease concentrations of TNF-α in older adults with mild cognitive impairment: A randomized, controlled, double blind clinical trial

Cited by 26 publications

References 54 publications

Ginkgo biloba in the Aging Process: A Narrative Review

Ginkgo biloba in the Aging Process: A Narrative Review

The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective

Plant-Based Foods and Vascular Function: A Systematic Review of Dietary Intervention Trials in Older Subjects and Hypothesized Mechanisms of Action

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