1990
DOI: 10.1136/adc.65.4.411
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Food and drug reactions, wheezing, and eczema in preterm infants.

Abstract: Allergic reactions were investigated in 777 preterm infants who were randomly assigned to early diet and followed up to 18 months post term. Wheezing or asthma was common (incidence 23%); it was associated with neonatal ventilation, maternal smoking, and a family history of atopy and was unexpectedly reduced in babies born by caesarean section. Even in non-ventilated infants, the incidence of subsequent wheezing was 18%, rising to an estimated 44% (using logistic regression) when the foregoing risk factors (ex… Show more

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Cited by 47 publications
(25 citation statements)
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“…These include: low birth weight (also in children born at term), maternal smoking (as a stimulant of IgE secretion through an IL-4-mediated mechanism), early and severe infection with respiratory syncytial virus (i.e. respiratory syncytial virus bronchiolitis), vaccination against Bordetella pertussis (induces a temporary increase in IgE production), and early contacts with allergens, such as house dust mite [22,26,30,34,40,41]. The latter seems to be extremely important, as it can induce permanent T h2 features leading to allergic reactions which can persist during longer time periods (years).…”
Section: Risk Factors To Develop Allergic Diseasesmentioning
confidence: 99%
“…These include: low birth weight (also in children born at term), maternal smoking (as a stimulant of IgE secretion through an IL-4-mediated mechanism), early and severe infection with respiratory syncytial virus (i.e. respiratory syncytial virus bronchiolitis), vaccination against Bordetella pertussis (induces a temporary increase in IgE production), and early contacts with allergens, such as house dust mite [22,26,30,34,40,41]. The latter seems to be extremely important, as it can induce permanent T h2 features leading to allergic reactions which can persist during longer time periods (years).…”
Section: Risk Factors To Develop Allergic Diseasesmentioning
confidence: 99%
“…These children had [1][2][3][4][5][6][7][8][9][10][11][12][13][14] 'asthmatic attacks' (median 3) during the past year. Table 2 shows the prevalence of LRI in four subgroups of preterm children: those who developed CLDN with or without prior RDS and those without CLDN with or without RDS.…”
Section: Resultsmentioning
confidence: 99%
“…The relation between the presence of CLDN and a family history of COPD, asthma, and allergy was evaluated in two respects: (1) From the relation between the presence or absence of CLDN in a study child and the probability of LRI in the corresponding family (as estimated from data on siblings within each family); (2) From the relation between the presence or absence of CLDN in a child and at least one of the parents and/or grandparents with a history of asthma (COPD, allergy).…”
Section: Discussionmentioning
confidence: 99%
“…Both preterm birth and birthweight have been associated with an excess of childhood respiratory morbidity in the form of symptoms (4)(5)(6), reduced lung function (5,(7)(8)(9)(10)(11), airway hyper-responsiveness (12) and diagnosed asthma (5,6,11,13), but the results of studies have not always been consistent. Low birthweight and preterm birth are more common among disadvantaged groups (14), among whom crowding and lower respiratory tract illness are more frequent; also, poor environmental conditions associated with asthma, eg, parental smoking, may be more likely to prevail (15).…”
Section: Poids De Naissance Et Prématurité En Relation Avec Des Indicmentioning
confidence: 88%