Respiratory illness in families of preterm infants with chronic lung disease.

Winter, Peter de; Sonderen, Loekie van; Anker, J. N. van den; Merth, I. T.; Brand, Roland; Bel, Frank van; Zonderland, Harmine M.; Quanjer, P. H.

doi:10.1136/fn.73.3.f147

Cited by 10 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore better to prevent than to cure RDS because the absence of RDS will result in reduced risks for developing CLDN, 18 even at 36 weeks' postconceptional age. 19 The prophylactic administration of surfactant is a significant factor (P Ͻ .01) in reducing the odds for mortality and severe RDS, and therefore also for CLDN. BW, gestational age, gender, and the prenatal administration of glucocorticosteroids are important confounders.…”

Section: Discussionmentioning

confidence: 99%

Mortality, Severe Respiratory Distress Syndrome, and Chronic Lung Disease of the Newborn Are Reduced More After Prophylactic Than After Therapeutic Administration of the Surfactant Curosurf

Egberts¹,

Brand

Walti

et al. 1997

Pediatrics

View full text Add to dashboard Cite

ABSTRACT.Objective. To test the hypothesis that prophylactic treatment with the surfactant Curosurf (Chiesi Farmaceutici SPA, Parma, Italy) improves survival and respiratory problems more than rescue treatment.Design. Meta-analysis of three prophylaxis versus rescue treatment trials, conducted in four countries.Methods. A meta-analysis was performed with the original, individual data of mortality, severe respiratory distress syndrome, and chronic lung disease of 671 newborns as outcomes. The random-effects logistic model (accounting for the trial-within-country structure) was applied and adjusted for imbalances in covariates.Results. The probability of each outcome differed between the countries, but the actual treatment effect itself did not. The adjusted odds ratios (ORs) and confidence intervals (CIs) for prophylaxis versus rescue were as follows: mortality: OR, .47; 95% CI, .30 to .73; severe RDS: OR, .50; 95% CI, .33 to .74; and chronic lung disease of the newborn in the survivors at day 28 after birth: OR, .54; 95% CI, .34 to .86. Gender, birth weight, gestational age, and prenatal administration of glucocorticosteroids were significant confounding covariates.Conclusion. The analysis shows that for the porcine surfactant Curosurf, prophylactic administration of surfactant has significant advantages over rescue therapy. Pediatrics 1997;100(1). URL: http://www.pediatrics.org/ cgi/content/full/100/1/e4; mortality; respiratory distress syndrome; chronic lung disease of the newborn; surfactant, prophylaxis, meta-analysis.ABBREVIATIONS. OR, odds ratio; CI, confidence interval; RDS, respiratory distress syndrome; CLDN, chronic lung disease of the newborn; BPD, bronchopulmonary dysplasia; RRR, relative reduction of the risk ratio; BW, birth weight. M eta-analyses have shown that prophylactic and rescue treatment with surfactant reduce mortality rate, severity of acute respiratory problems, and the incidence of chronic lung disease in preterm newborns.

show abstract

Section: Discussionmentioning

confidence: 99%

Mortality, Severe Respiratory Distress Syndrome, and Chronic Lung Disease of the Newborn Are Reduced More After Prophylactic Than After Therapeutic Administration of the Surfactant Curosurf

Egberts¹,

Brand

Walti

et al. 1997

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Data from older studies have suggested a relationship between “old” BPD and first‐ or second‐degree relatives with a history of asthma 14 . However other studies demonstrated no difference in severity of BPD in children and FHA 15,16 or if FHA is associated with an increase risk for respiratory symptoms after NICU discharge.…”

Section: Introductionmentioning

confidence: 91%

Family history of asthma influences outpatient respiratory outcomes in children with BPD

McGlynn

Aoyama

Collaco

et al. 2021

Pediatric Pulmonology

View full text Add to dashboard Cite

Introduction Preterm children with bronchopulmonary dysplasia (BPD) are at increased risk for intermittent and chronic respiratory symptoms during childhood and adult life. Identifying children at higher risk for respiratory morbidities in the outpatient setting could help improve long‐term outcomes. In this study, we hypothesized that a family history of asthma (FHA) is a risk factor for higher acute care usage and respiratory symptoms in preterm infants/children with BPD, following initial discharge home. Methods Subjects were recruited from the Johns Hopkins Bronchopulmonary Dysplasia outpatient clinic between January 2008 and February 2020 (n = 827). Surveys were administered to caregivers and demographics and clinical characteristics were obtained through chart review. Results Demographic features associated with FHA included public health insurance, lower median household income, and nonwhite race. Children with FHA had higher odds of emergency department (ED) visits, systemic steroid use, nighttime respiratory symptoms, and activity limitations. There was no association between FHA and BPD severity. Conclusion This study found that children with BPD and FHA were more likely to have respiratory symptoms and acute care usage during the first 3 years of life and that FHA was associated with lower socioeconomic status. Although there was no association between FHA and BPD severity, FHA could predict an increased likelihood of both ED visits and need for systemic steroids in infants/children with BPD followed in the outpatient setting.

show abstract

“…Moreover, experimental studies in the rat suggest that it may inhibit alveolar development. 49 The effect of other treatments such as surfactant replacement therapy 50 or antioxidant enzymes 51 on lung development and growth are not known.…”

mentioning

confidence: 99%

Bronchopulmonary dysplasia: Pre- and postnatal influences and outcome

Hislop¹

1997

Pediatr. Pulmonol.

View full text Add to dashboard Cite

Respiratory illness in families of preterm infants with chronic lung disease.

Cited by 10 publications

References 39 publications

Mortality, Severe Respiratory Distress Syndrome, and Chronic Lung Disease of the Newborn Are Reduced More After Prophylactic Than After Therapeutic Administration of the Surfactant Curosurf

Mortality, Severe Respiratory Distress Syndrome, and Chronic Lung Disease of the Newborn Are Reduced More After Prophylactic Than After Therapeutic Administration of the Surfactant Curosurf

Family history of asthma influences outpatient respiratory outcomes in children with BPD

Bronchopulmonary dysplasia: Pre- and postnatal influences and outcome

Contact Info

Product

Resources

About