Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model

Li, Xiumin; Zhang, Tengfei; Huang, Chih-Kang; Srivastava, Kamal; Teper, Ariel; Zhang, Libang; Schofield, Brian; Sampson, Hugh A.

doi:10.1067/mai.2001.118787

Cited by 149 publications

(90 citation statements)

References 25 publications

(26 reference statements)

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“…The mechanism appears to be partially related to suppression of Th2 responses and enhancement of Th1 responses, as production of IL-4, IL-5, and IL-13 was significantly reduced with treatment, while IFN-γ production increased (103). In the murine model, suppression of anaphylactic reactions lasted at least six months after treatment (104,105).…”

Section: Pathophysiology Of Food Allergymentioning

confidence: 98%

Emerging therapies for food allergy

Keet¹,

Wood²

2014

J. Clin. Invest.

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Food allergy is a common condition for which there are currently no approved treatments except avoidance of the allergenic food and treatment of accidental reactions. There are several potential treatments that are under active investigation in animal and human studies, but it is not yet clear what the best approach may be. Here, we review approaches that are currently in clinical trials, including oral, sublingual, and epicutaneous immunotherapy, immunotherapy combined with anti-IgE, and Chinese herbal medicine as well as approaches that are in preclinical or early clinical investigation, including modified protein immunotherapy, adjuvants, DNA vaccines, and helminth administration. We discuss the importance of fully exploring the risks and benefits of any treatment before it is taken to general clinical practice and the need for clarity about the goals of treatment.

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Section: Pathophysiology Of Food Allergymentioning

confidence: 98%

Emerging therapies for food allergy

Keet¹,

Wood²

2014

J. Clin. Invest.

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“…Indeed, our data show that 80% of mice reached a clinical score of ϳ3.5 and a very robust ϳ8°C drop in core body temperature. We did perform a number of detailed experiments using previously reported protocols and explored a series of methodological variations including: an increase in the number of oral sensitizations to up to eight, executing two oral challenges rather than one (17,21), and increasing gut permeability and absorption of Ag with ethanol (22) at the time of challenge. However, we were not able to elicit consistent anaphylactic reactions not only in C57BL/6 mice but also in C3H/HeJ mice.…”

Section: Discussionmentioning

confidence: 99%

Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses

Sun

Arias

Álvarez

et al. 2007

The Journal of Immunology

106

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The effector immune mechanisms underlying peanut-induced anaphylaxis remain to be fully elucidated. We investigated the relative contribution of Igs, mast cells (MCs), and FcεRI in the elicitation of anaphylaxis in a murine model. Assessment of peanut hypersensitivity reactions was performed clinically and biologically. Our data show that wild-type (WT; C57BL/6 strain) mice consistently developed severe anaphylaxis (median clinical score: 3.5/5), an ∼8°C drop in core body temperature, and significantly increased plasma levels of histamine and leukotrienes. CD40 ligand- and B cell-deficient mice presented evidence of allergic sensitization as demonstrated by production of Th2-associated cytokines by splenocytes and a late-phase inflammatory response that were both indistinguishable to those detected in WT mice. However, CD40 ligand- and B cell-deficient mice did not exhibit any evidence of anaphylaxis. Our data also show that MC-deficient (KitW/KitW-v) mice did not suffer, unlike their littermate controls, anaphylactic reactions despite the fact that serum levels of peanut-specific Igs were similarly elevated. Finally, FcεRI-deficient mice experienced anaphylactic responses although to a significantly lesser degree than those observed in WT mice. Thus, these data demonstrate that the presence of peanut-specific Abs along with functional MCs comprise a necessary and sufficient condition for the elicitation of peanut-induced anaphylaxis. That the absence of FcεRI prevented the development of anaphylaxis only partially insinuates the contribution of an IgE-independent pathway, and suggests that strategies to impair MC degranulation may be necessary to improve the efficacy of anti-IgE therapy.

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“…We then extended the study and found that FAHF-2-treated mice were completely protected from anaphylaxis following challenge for up to 5 wks post-therapy, and that reduced IgE levels remained significantly lower at 5 wks posttherapy. Complete protection was confirmed using several well-established parameters, including anaphylactic symptom scores, decreased core body temperatures, elevated plasma histamine levels [32] and vascular leakage. [33] This therapeutic effect was associated with immunoregulatory effects on Th1-Th2 responses.…”

Section: Part II Potential Traditional Chinese Medicine Therapy For mentioning

confidence: 99%

“…We named the refined formula FAHF-2. A preliminary study [32] found that, as with FAHF-1, FAHF-2 also completely blocked peanut-induced anaphylaxis. We then extended the study and found that FAHF-2-treated mice were completely protected from anaphylaxis following challenge for up to 5 wks post-therapy, and that reduced IgE levels remained significantly lower at 5 wks posttherapy.…”

Section: Part II Potential Traditional Chinese Medicine Therapy For mentioning

confidence: 99%

Traditional Chinese herbal remedies for asthma and food allergy

Li¹

2007

Journal of Allergy and Clinical Immunology

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The increasing prevalence of allergic diseases in westernized countries is a significant health problem. Curative therapies for these diseases are not available. There are also significant concerns regarding the potential side effects from the chronic use of conventional drugs such as corticosteroids, especially in children. Many patients with chronic allergic conditions seek complementary and alternative medicine (CAM) therapies including traditional Chinese medicines (TCM). This trend has begun to attract interest from the mainstream healthcare providers and scientific investigators, and has stimulated government agencies in the US to provide support and guidance for the scientific investigation of CAM. This effort may lead to improved therapies and better healthcare/patient outcomes. This review presents an update on the most promising Chinese herbal remedies for asthma and food allergy.

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Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model

Cited by 149 publications

References 25 publications

Emerging therapies for food allergy

Emerging therapies for food allergy

Impact of CD40 Ligand, B Cells, and Mast Cells in Peanut-Induced Anaphylactic Responses

Traditional Chinese herbal remedies for asthma and food allergy

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