Emerging therapies for food allergy

Keet, Corinne A.; Wood, Robert A.

doi:10.1172/jci72061

Cited by 52 publications

(33 citation statements)

References 119 publications

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“…Although the mechanism of oral immunotherapy is not completely understood, it is speculated that desensitization is achieved by evoking suppressor T cell activity, decrease specific IgE levels, while increasing specific IgG4 levels [89]. A recent study implicates IgG4 involvement in EoE pathogenesis [85].…”

Section: Eoe and Ige-mediated Allergymentioning

confidence: 99%

Translating New Developments in Eosinophilic Esophagitis Pathogenesis into Clinical Practice

Cheng

2015

Curr Treat Options Gastro

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Opinion Statement New developments in eosinophilic esophagitis pathogenesis are shaping our current therapeutic and management strategies. EoE is a chronic allergic inflammatory disease with progression to fibrostenotic disease. The disease warrants early diagnosis and long-term maintenance therapy. The diagnosis of EoE should be based on the concept of an allergy-mediated disease with esophageal dysfunction and esophageal eosinophilia. Recent findings suggest PPI-REE is likely a continuum of EoE or similar Th2-mediated allergic process. PPIs have therapeutic properties that can benefit both GERD and EoE. Therefore, PPIs should not be considered a diagnostic tool, but rather a therapeutic option for EoE. If patients are PPI-nonresponsive, then dietary therapy or steroid therapy should be considered. Dilation can be reserved as adjuvant therapy for severe fibrostenotic lesions.

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Section: Eoe and Ige-mediated Allergymentioning

confidence: 99%

Translating New Developments in Eosinophilic Esophagitis Pathogenesis into Clinical Practice

Cheng

2015

Curr Treat Options Gastro

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“…OIT studies in general have a significant dropout rate, as high as 20% in some studies, owing mostly to GI symptoms that often start in the first few days of dosing and do not resolve [59].…”

Section: Safetymentioning

confidence: 99%

Food specific oral immunotherapy: a potential treatment for food allergy

Burbank¹,

Burks

2015

Expert Review of Gastroenterology & Hepatology

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Food allergy is a potentially life-threatening condition affecting up to 8% of children and up to 2% of adults in westernized countries. There are currently no approved treatments for food allergy apart from avoidance. The apparent increase in incidence of food allergies over the past few decades calls attention to the need for effective, disease-modifying therapies for food allergies. Oral immunotherapy (OIT) is a promising experimental treatment in which food allergic patients consume increasing quantities of food in attempt to increase their threshold for allergic reaction. Studies are ongoing to determine whether OIT is capable of safely inducing not only desensitization but also tolerance to the allergenic foods. This article focuses on recent relevant studies of OIT for the treatment of common food allergies.

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“…Trials involving combinations of the above, with or without immunobiologic agents or probiotic adjuvants, will continue as researchers continue to fine-tune their approach. Preclinical studies involving novel therapies such as helminthes, DNA vaccines and toll-like receptor agonists are currently underway [88,89].…”

Section: On the Horizonmentioning

confidence: 99%

Pharmacologic options for the treatment and management of food allergy

Kobernick

Chambliss

Burks³

2015

Expert Review of Clinical Pharmacology

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Food allergy affects approximately 5% of adults and 8% of children in developed countries, and there is currently no cure. Current pharmacologic management is limited to using intramuscular epinephrine or oral antihistamines in response to food allergen exposure. Recent trials have examined the efficacy and safety of subcutaneous, oral, sublingual, and epicutaneous immunotherapy, with varying levels of efficacy and safety demonstrated. Bacterial adjuvants, use of anti-IgE monoclonal antibodies, and Chinese herbal formulations represent exciting potential for development of future pharmacotherapeutic agents. Ultimately, immunotherapy may be a viable option for patients with food allergy, although efficacy and safety are likely to be less than ideal.

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Emerging therapies for food allergy

Cited by 52 publications

References 119 publications

Translating New Developments in Eosinophilic Esophagitis Pathogenesis into Clinical Practice

Translating New Developments in Eosinophilic Esophagitis Pathogenesis into Clinical Practice

Food specific oral immunotherapy: a potential treatment for food allergy

Pharmacologic options for the treatment and management of food allergy

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